Backgound Essential hypertension （EH） is a polygenic inheritable disease,generally known as a combined result of genetic and environmental elements.It is possible that IR、AngiotensinⅡ（AngⅡ） and NO play importan...Backgound Essential hypertension （EH） is a polygenic inheritable disease,generally known as a combined result of genetic and environmental elements.It is possible that IR、AngiotensinⅡ（AngⅡ） and NO play important roles in the pathogenesis of EH.Methods Sixty normal subjects with a family history of EH,aged 30 to 40 years old,were recruited and randomized into two groups：30 with one parent and 30 with both parents with EH,and 30 subjects without family history of EH as controls.The plasma level of NO was determined by electrophotometer while the plasma level of fast insulin （FINS） and AngⅡ were determined by radioimmuno-assay,and insulin resistance index （IRI） was calculated.Results ① The plasma levels of FINS,AngⅡ,NO increased significantly in study groups compared with those in the control group（P 0.01）,while there were no differences in the levels of AngII,NO between the two study groups （P 0.05）.② The plasma level of AngII were positively correlated with that of NO（r=0.378,P 0.01）.Conclusions The higher levels of IR and plasma AngII and NO exist before the development of EH in normal offspring with a family history of EH,and maybe they are initial agents in the pathogenesis of EH.It indicates that the people with IR and high levels of plasma AngⅡand NO with a family history of EH are at higher risk to develop EH.展开更多
Objectives To study the relation between night urinary free cortisol (UFC) excretion and hypertension in youth. Methods Night urinary free cortisol excretion and blood pressure & its related factor were measured i...Objectives To study the relation between night urinary free cortisol (UFC) excretion and hypertension in youth. Methods Night urinary free cortisol excretion and blood pressure & its related factor were measured in 188 young people. Results In young men with hypertension the 8 h's night UFC excretion was significantly higher than that in the group with normal blood pressure 21. 57±6. 28μg/8 h vs 10. 54 ± 5. 46 μg/8 h ( P < 0. 05) . In a group of young people with positive family history of hypertension, the night UFC excretion was much higher than that in the group with negative family history of hypertension. Men excrete much more night UFC than women (12. 73 ± 5. 85 μg/8 h vs 7. 80 ± 4. 15 μg/8 h, P < 0. 05). Conclusions There is an association between hypertension and high 8h's night UFC excretion; furthermore, there is gender difference in night UFC excretion.展开更多
文摘Backgound Essential hypertension （EH） is a polygenic inheritable disease,generally known as a combined result of genetic and environmental elements.It is possible that IR、AngiotensinⅡ（AngⅡ） and NO play important roles in the pathogenesis of EH.Methods Sixty normal subjects with a family history of EH,aged 30 to 40 years old,were recruited and randomized into two groups：30 with one parent and 30 with both parents with EH,and 30 subjects without family history of EH as controls.The plasma level of NO was determined by electrophotometer while the plasma level of fast insulin （FINS） and AngⅡ were determined by radioimmuno-assay,and insulin resistance index （IRI） was calculated.Results ① The plasma levels of FINS,AngⅡ,NO increased significantly in study groups compared with those in the control group（P 0.01）,while there were no differences in the levels of AngII,NO between the two study groups （P 0.05）.② The plasma level of AngII were positively correlated with that of NO（r=0.378,P 0.01）.Conclusions The higher levels of IR and plasma AngII and NO exist before the development of EH in normal offspring with a family history of EH,and maybe they are initial agents in the pathogenesis of EH.It indicates that the people with IR and high levels of plasma AngⅡand NO with a family history of EH are at higher risk to develop EH.
文摘Objectives To study the relation between night urinary free cortisol (UFC) excretion and hypertension in youth. Methods Night urinary free cortisol excretion and blood pressure & its related factor were measured in 188 young people. Results In young men with hypertension the 8 h's night UFC excretion was significantly higher than that in the group with normal blood pressure 21. 57±6. 28μg/8 h vs 10. 54 ± 5. 46 μg/8 h ( P < 0. 05) . In a group of young people with positive family history of hypertension, the night UFC excretion was much higher than that in the group with negative family history of hypertension. Men excrete much more night UFC than women (12. 73 ± 5. 85 μg/8 h vs 7. 80 ± 4. 15 μg/8 h, P < 0. 05). Conclusions There is an association between hypertension and high 8h's night UFC excretion; furthermore, there is gender difference in night UFC excretion.
