This paper presents a numerical investigation of the potential aerodynamic benefits of using endwall contouring in a fairly aggressive duct with six struts based on the platform for endwall design optimization.The pla...This paper presents a numerical investigation of the potential aerodynamic benefits of using endwall contouring in a fairly aggressive duct with six struts based on the platform for endwall design optimization.The platform is constructed by integrating adaptive genetic algorithm（AGA）, design of experiments（DOE）, response surface methodology（RSM） based on the artificial neural network（ANN）, and a 3D Navier–Stokes solver.The visual analysis method based on DOE is used to define the design space and analyze the impact of the design parameters on the target function（response）.Optimization of the axisymmetric and the non-axisymmetric endwall contouring in an S-shaped duct is performed and evaluated to minimize the total pressure loss.The optimal ducts are found to reduce the hub corner separation and suppress the migration of the low momentum fluid.The non-axisymmetric endwall contouring is shown to remove the separation completely and reduce the net duct loss by 32.7%.展开更多
In the present study,a response optimization method using Extreme Vertices Mixer Design(EVMD)approach is proposed for stress optimization in a thermomechanically processed Mg-Li-Al alloy.Experimentation was planned as...In the present study,a response optimization method using Extreme Vertices Mixer Design(EVMD)approach is proposed for stress optimization in a thermomechanically processed Mg-Li-Al alloy.Experimentation was planned as per mixed design proportions of Mg,Li and Al and process variables(i.e.temperature and strain rate).Each experiment has been performed under different conditions of factors proportions and process variables.The response,particularly stress has been considered for each experiment.The response is optimized to find an optimum condition when the contributing factors influence material characteristics in such a way,to achieve better strength,ductility and corrosion resistance.Estimated regression coefficient table for response has been observed to identify the important factors in this process and significantly high variance inflation factor has been observed.Most importantly,an optimum condition is achieved from this analysis which fulfills the experimental observations and theoretical assumptions.展开更多
This research introduces a novel approach to enhancing bucket elevator design and operation through the integration of discrete element method(DEM)simulation,design of experiments(DOE),and metaheuristic optimization a...This research introduces a novel approach to enhancing bucket elevator design and operation through the integration of discrete element method(DEM)simulation,design of experiments(DOE),and metaheuristic optimization algorithms.Specifically,the study employs the firefly algorithm(FA),a metaheuristic optimization technique,to optimize bucket elevator parameters for maximizing transport mass and mass flow rate discharge of granular materials under specified working conditions.The experimental methodology involves several key steps:screening experiments to identify significant factors affecting bucket elevator operation,central composite design(CCD)experiments to further explore these factors,and response surface methodology(RSM)to create predictive models for transport mass and mass flow rate discharge.The FA algorithm is then applied to optimize these models,and the results are validated through simulation and empirical experiments.The study validates the optimized parameters through simulation and empirical experiments,comparing results with DEM simulation.The outcomes demonstrate the effectiveness of the FA algorithm in identifying optimal bucket parameters,showcasing less than 10%and 15%deviation for transport mass and mass flow rate discharge,respectively,between predicted and actual values.Overall,this research provides insights into the critical factors influencing bucket elevator operation and offers a systematic methodology for optimizing bucket parameters,contributing to more efficient material handling in various industrial applications.展开更多
Lattice structures are three-dimensional structures composed of repeated geometrical shapes with multiple interconnected nodes,providing high strength-to-weight ratios,customizable properties,and efficient use of mate...Lattice structures are three-dimensional structures composed of repeated geometrical shapes with multiple interconnected nodes,providing high strength-to-weight ratios,customizable properties,and efficient use of materials.A smart use of materials leads to reduced fuel consumption and lower operating costs,making them highly desirable for aircraft manufacturers.Furthermore,the customizable properties of lattice structures allow for tailoring to specific design requirements,leading to improved performance and safety for aircraft.These advantages make lattice structures an important focus for research and development in the aviation industry.This paper presents an experimental evaluation of the mechanical compression properties of lattice trusses made with Ti6Al4V,designed for use in an anti-ice system.The truss structures were manufactured using additive manufacturing techniques and tested under compressive loads to determine mechanical properties.Results showed that lattice trusses exhibited high levels of compressive strength,making them suitable for use in applications where mechanical resistance and durability are critical,such as in anti-ice systems.We also highlight the potential of additive manufacturing techniques for the fabrication of lattice trusses with tailored mechanical properties.The study provides valuable insights into the mechanical behavior of Ti6Al4V lattice trusses and their potential applications in anti-ice systems,as well as other areas where high strength-to-weight ratios are required.The results of this research contribute to the development of lightweight,efficient,and durable anti-ice systems for use in aviation and other industries.展开更多
The present study aims at introducing a newly developed natural fiber called castor oil fiber,termed ricinus communis,as a possible reinforcement in tribo-composites.Unidirectional short castor oil fiber reinforced ep...The present study aims at introducing a newly developed natural fiber called castor oil fiber,termed ricinus communis,as a possible reinforcement in tribo-composites.Unidirectional short castor oil fiber reinforced epoxy resin composites of different fiber lengths with 40%volume fraction were fabricated using hand layup technique.Dry sliding wear tests were performed on a pin-on-disc tribometer based on full factorial design of experiments(DoE)at four fiber lengths(5,10,15,and 20 mm),three normal loads(15,30,and 45 N),and three sliding distances(1,000,2,000,and 3,000 m).The effect of individual parameters on the amount of wear,interfacial temperature,and coefficient of friction was studied using analysis of variance(ANOVA).The composite with 5 mm fiber length provided the best tribological properties than 10,15,and 20 mm fiber length composites.The worn surfaces were analyzed under scanning electron microscope.Also,the tribological behavior of the composites was predicted using regression,artificial neural network(ANN)-single hidden layer,and ANN-multi hidden layer models.The confirmatory test results show the reliability of predicted models.ANN with multi hidden layers are found to predict the tribological performance accurately and then followed by ANN with single hidden layer and regression model.展开更多
In this paper,size and shape optimization problem of a machine gun system is addressed with an efficient hybrid method,in which a novel and flexible mesh morphing technique is employed to achieve fast parameterization...In this paper,size and shape optimization problem of a machine gun system is addressed with an efficient hybrid method,in which a novel and flexible mesh morphing technique is employed to achieve fast parameterization and modification of complexity structure without going back to CAD for reconstruction of geometric models or to finite element analysis（ FEA） for remodeling. Design of experiments（ DOE） and response surface method（ RSM） are applied to approximate the constitutive parameters of a machine gun system based on experimental tests. Further FEA,secondary development technique and genetic algorithm（ GA） are introduced to find all the optimal solutions in one go and the optimal design of the demonstrated machine gun system is obtained. Results of the rigid-flexible coupling dynamic analysis and exterior ballistics calculation validate the proposed methodology,which is relatively time-saving,reliable and has the potential to solve similar problems.展开更多
A renaissance in cell-free protein synthesis(CFPS)is underway,enabled by the acceleration and adoption of synthetic biology methods.CFPS has emerged as a powerful platform technology for synthetic gene network design,...A renaissance in cell-free protein synthesis(CFPS)is underway,enabled by the acceleration and adoption of synthetic biology methods.CFPS has emerged as a powerful platform technology for synthetic gene network design,biosensing and on-demand biomanufacturing.Whilst primarily of bacterial origin,cell-free extracts derived from a variety of host organisms have been explored,aiming to capitalise on cellular diversity and the advantageous properties associated with those organisms.However,cell-free extracts produced from eukaryotes are often overlooked due to their relatively low yields,despite the potential for improved protein folding and posttranslational modifications.Here we describe further development of a Pichia pastoris cell-free platform,a widely used expression host in both academia and the biopharmaceutical industry.Using a minimised Design of Experiments(DOE)approach,we were able to increase the productivity of the system by improving the composition of the complex reaction mixture.This was achieved in a minimal number of experimental runs,within the constraints of the design and without the need for liquid-handling robots.In doing so,we were able to estimate the main effects impacting productivity in the system and increased the protein synthesis of firefly luciferase and the biopharmaceutical HSA by 4.8-fold and 3.5-fold,respectively.This study highlights the P.pastoris-based cell-free system as a highly productive eukaryotic platform and displays the value of minimised DOE designs.展开更多
Biofilm-forming microorganisms are ubiquitous, but continuous cultivation of these microorganisms with predictable biofilm growth and structural properties remains challenging. The development of a reliable simulated ...Biofilm-forming microorganisms are ubiquitous, but continuous cultivation of these microorganisms with predictable biofilm growth and structural properties remains challenging. The development of a reliable simulated biofilm has been limited by a lack of information about the microorganism subpopulations and fluid-structure interactions involved in biofilm formation and detachment due to mechanical stress. This paper presents a gellan-based hydrogel as an alternative material for a simulated physicochemical biofilm. The mechanical properties of the hydrogel in terms of the storage (G') and loss (G'') moduli can be tuned and adapted to imitate biofilms of different strengths by changing the concentration of gellan and mono(Na+) or divalent (Mg2+) ions. The storage modulus of the hydrogel ranges from 2 to 20 kPa, and the loss modulus ranges from 0.1 to 2.0 kPa. The material constants of the hydrogels and biofilms of Pseudomonas putida KT2440 were experimentally determined by rheometric analysis. A simplified biofilm imitate based on highly hydrolyzed gellan hydrogels was established by using experimental design techniques that permitted independent analyses regardless of growth. This model system design was compared to real biofilms and was adapted to mimic the mechanical properties of biofilms by changing the hydrogel composition, resulting in biofilm-like viscoelastic behavior. The use of a gellan-based hydrogel enables the imitation of biofilm behavior in the absence of growth effects, thus simplifying the system. Biofilm characterization tools can be tested and verified before their application to the measurement of slow-growing, highly variable biofilms to estimate system errors, which are often smaller than the biological variations. In general, this method permits faster and more reliable testing of biofilm mechanical properties.展开更多
针对轨道弹条扣件断裂率较高的问题,使用ABAQUS进行有限元分析,计算弹条的应力分布和位移变化情况。为提高弹条优化分析效率,采用正交数组试验设计(design of experiments,DOE),获得对弹条性能影响较大的几何参数。基于Isight平台集成So...针对轨道弹条扣件断裂率较高的问题,使用ABAQUS进行有限元分析,计算弹条的应力分布和位移变化情况。为提高弹条优化分析效率,采用正交数组试验设计(design of experiments,DOE),获得对弹条性能影响较大的几何参数。基于Isight平台集成SolidWorks和ABAQUS,利用Python编写仿真流程脚本。在标准安装约束下,以几何参数为设计变量,以弹条优化指标为目标函数,对弹条进行优化设计。结果表明:优化后,弹条质量减少2.1%,最大应力减小9.1%,弹条优化指标提高12.3%,弹条性能提升且在相同弹程下,扣压力满足标准要求,可为弹条设计提供参考。展开更多
为解决某型脉冲增压柴油机第8缸排温高以及排温不均匀问题,基于GT-power仿真软件建立了柴油机仿真模型,利用多试验设计(design of experiments,DOE)实验设计方法对排气管结构进行了优化设计。结果表明,DOE方法可以辨识出结构参数和排气...为解决某型脉冲增压柴油机第8缸排温高以及排温不均匀问题,基于GT-power仿真软件建立了柴油机仿真模型,利用多试验设计(design of experiments,DOE)实验设计方法对排气管结构进行了优化设计。结果表明,DOE方法可以辨识出结构参数和排气温度之间的映射关系,在Optimizer优化控制器可以快速得出最优的结构参数组合,优化后的排气管解决了第8缸排温高的问题,同时有效改善了各缸排温不均匀性。展开更多
目前海上风机基础结构存在明显的设计冗余,导致海上风机建造成本过高。为提高经济效益,需要对导管架式海上风机基础结构进行优化设计。该文首先基于海上实测数据对海上风机所处环境载荷进行模拟,得到其时间历程;其次通过有限元方法对平...目前海上风机基础结构存在明显的设计冗余,导致海上风机建造成本过高。为提高经济效益,需要对导管架式海上风机基础结构进行优化设计。该文首先基于海上实测数据对海上风机所处环境载荷进行模拟,得到其时间历程;其次通过有限元方法对平箱梁四桩导管架式海上风机基础结构进行强度校核,发现结构可进行轻量化处理;最后以结构最大平均应力、最大位移和质量为目标响应,通过试验设计(design of experiments,DOE)方法和粒子群算法组合的优化方法,得到结构尺寸对结构目标响应的贡献度和主效应关系,并确定各结构最优尺寸。对海上风机基础结构进行优化设计,能在保证安全的前提下降低建造成本,可为后续海上风机基础结构设计建造提供参数参考。展开更多
基金supported by the National Natural Science Foundation of China (Nos.51006005, 51236001)the National Basic Research Program of China (No.2012CB720201)the Fundamen tal Research Funds for the Central Universities of China
文摘This paper presents a numerical investigation of the potential aerodynamic benefits of using endwall contouring in a fairly aggressive duct with six struts based on the platform for endwall design optimization.The platform is constructed by integrating adaptive genetic algorithm（AGA）, design of experiments（DOE）, response surface methodology（RSM） based on the artificial neural network（ANN）, and a 3D Navier–Stokes solver.The visual analysis method based on DOE is used to define the design space and analyze the impact of the design parameters on the target function（response）.Optimization of the axisymmetric and the non-axisymmetric endwall contouring in an S-shaped duct is performed and evaluated to minimize the total pressure loss.The optimal ducts are found to reduce the hub corner separation and suppress the migration of the low momentum fluid.The non-axisymmetric endwall contouring is shown to remove the separation completely and reduce the net duct loss by 32.7%.
文摘In the present study,a response optimization method using Extreme Vertices Mixer Design(EVMD)approach is proposed for stress optimization in a thermomechanically processed Mg-Li-Al alloy.Experimentation was planned as per mixed design proportions of Mg,Li and Al and process variables(i.e.temperature and strain rate).Each experiment has been performed under different conditions of factors proportions and process variables.The response,particularly stress has been considered for each experiment.The response is optimized to find an optimum condition when the contributing factors influence material characteristics in such a way,to achieve better strength,ductility and corrosion resistance.Estimated regression coefficient table for response has been observed to identify the important factors in this process and significantly high variance inflation factor has been observed.Most importantly,an optimum condition is achieved from this analysis which fulfills the experimental observations and theoretical assumptions.
基金This research was funded by the Faculty of Engineering,King Mongkut’s University of Technology North Bangkok.Contract No.ENG-NEW-66-39.
文摘This research introduces a novel approach to enhancing bucket elevator design and operation through the integration of discrete element method(DEM)simulation,design of experiments(DOE),and metaheuristic optimization algorithms.Specifically,the study employs the firefly algorithm(FA),a metaheuristic optimization technique,to optimize bucket elevator parameters for maximizing transport mass and mass flow rate discharge of granular materials under specified working conditions.The experimental methodology involves several key steps:screening experiments to identify significant factors affecting bucket elevator operation,central composite design(CCD)experiments to further explore these factors,and response surface methodology(RSM)to create predictive models for transport mass and mass flow rate discharge.The FA algorithm is then applied to optimize these models,and the results are validated through simulation and empirical experiments.The study validates the optimized parameters through simulation and empirical experiments,comparing results with DEM simulation.The outcomes demonstrate the effectiveness of the FA algorithm in identifying optimal bucket parameters,showcasing less than 10%and 15%deviation for transport mass and mass flow rate discharge,respectively,between predicted and actual values.Overall,this research provides insights into the critical factors influencing bucket elevator operation and offers a systematic methodology for optimizing bucket parameters,contributing to more efficient material handling in various industrial applications.
文摘Lattice structures are three-dimensional structures composed of repeated geometrical shapes with multiple interconnected nodes,providing high strength-to-weight ratios,customizable properties,and efficient use of materials.A smart use of materials leads to reduced fuel consumption and lower operating costs,making them highly desirable for aircraft manufacturers.Furthermore,the customizable properties of lattice structures allow for tailoring to specific design requirements,leading to improved performance and safety for aircraft.These advantages make lattice structures an important focus for research and development in the aviation industry.This paper presents an experimental evaluation of the mechanical compression properties of lattice trusses made with Ti6Al4V,designed for use in an anti-ice system.The truss structures were manufactured using additive manufacturing techniques and tested under compressive loads to determine mechanical properties.Results showed that lattice trusses exhibited high levels of compressive strength,making them suitable for use in applications where mechanical resistance and durability are critical,such as in anti-ice systems.We also highlight the potential of additive manufacturing techniques for the fabrication of lattice trusses with tailored mechanical properties.The study provides valuable insights into the mechanical behavior of Ti6Al4V lattice trusses and their potential applications in anti-ice systems,as well as other areas where high strength-to-weight ratios are required.The results of this research contribute to the development of lightweight,efficient,and durable anti-ice systems for use in aviation and other industries.
文摘The present study aims at introducing a newly developed natural fiber called castor oil fiber,termed ricinus communis,as a possible reinforcement in tribo-composites.Unidirectional short castor oil fiber reinforced epoxy resin composites of different fiber lengths with 40%volume fraction were fabricated using hand layup technique.Dry sliding wear tests were performed on a pin-on-disc tribometer based on full factorial design of experiments(DoE)at four fiber lengths(5,10,15,and 20 mm),three normal loads(15,30,and 45 N),and three sliding distances(1,000,2,000,and 3,000 m).The effect of individual parameters on the amount of wear,interfacial temperature,and coefficient of friction was studied using analysis of variance(ANOVA).The composite with 5 mm fiber length provided the best tribological properties than 10,15,and 20 mm fiber length composites.The worn surfaces were analyzed under scanning electron microscope.Also,the tribological behavior of the composites was predicted using regression,artificial neural network(ANN)-single hidden layer,and ANN-multi hidden layer models.The confirmatory test results show the reliability of predicted models.ANN with multi hidden layers are found to predict the tribological performance accurately and then followed by ANN with single hidden layer and regression model.
基金Supported by the National Natural Science Foundation of China(51376090,51676099)
文摘In this paper,size and shape optimization problem of a machine gun system is addressed with an efficient hybrid method,in which a novel and flexible mesh morphing technique is employed to achieve fast parameterization and modification of complexity structure without going back to CAD for reconstruction of geometric models or to finite element analysis（ FEA） for remodeling. Design of experiments（ DOE） and response surface method（ RSM） are applied to approximate the constitutive parameters of a machine gun system based on experimental tests. Further FEA,secondary development technique and genetic algorithm（ GA） are introduced to find all the optimal solutions in one go and the optimal design of the demonstrated machine gun system is obtained. Results of the rigid-flexible coupling dynamic analysis and exterior ballistics calculation validate the proposed methodology,which is relatively time-saving,reliable and has the potential to solve similar problems.
基金This research is funded by the Department of Health and Social Care using UK Aid funding and is managed by the Engineering and Physical Sciences Research Council(EPSRC,grant number:EP/R013764/1).
文摘A renaissance in cell-free protein synthesis(CFPS)is underway,enabled by the acceleration and adoption of synthetic biology methods.CFPS has emerged as a powerful platform technology for synthetic gene network design,biosensing and on-demand biomanufacturing.Whilst primarily of bacterial origin,cell-free extracts derived from a variety of host organisms have been explored,aiming to capitalise on cellular diversity and the advantageous properties associated with those organisms.However,cell-free extracts produced from eukaryotes are often overlooked due to their relatively low yields,despite the potential for improved protein folding and posttranslational modifications.Here we describe further development of a Pichia pastoris cell-free platform,a widely used expression host in both academia and the biopharmaceutical industry.Using a minimised Design of Experiments(DOE)approach,we were able to increase the productivity of the system by improving the composition of the complex reaction mixture.This was achieved in a minimal number of experimental runs,within the constraints of the design and without the need for liquid-handling robots.In doing so,we were able to estimate the main effects impacting productivity in the system and increased the protein synthesis of firefly luciferase and the biopharmaceutical HSA by 4.8-fold and 3.5-fold,respectively.This study highlights the P.pastoris-based cell-free system as a highly productive eukaryotic platform and displays the value of minimised DOE designs.
文摘Biofilm-forming microorganisms are ubiquitous, but continuous cultivation of these microorganisms with predictable biofilm growth and structural properties remains challenging. The development of a reliable simulated biofilm has been limited by a lack of information about the microorganism subpopulations and fluid-structure interactions involved in biofilm formation and detachment due to mechanical stress. This paper presents a gellan-based hydrogel as an alternative material for a simulated physicochemical biofilm. The mechanical properties of the hydrogel in terms of the storage (G') and loss (G'') moduli can be tuned and adapted to imitate biofilms of different strengths by changing the concentration of gellan and mono(Na+) or divalent (Mg2+) ions. The storage modulus of the hydrogel ranges from 2 to 20 kPa, and the loss modulus ranges from 0.1 to 2.0 kPa. The material constants of the hydrogels and biofilms of Pseudomonas putida KT2440 were experimentally determined by rheometric analysis. A simplified biofilm imitate based on highly hydrolyzed gellan hydrogels was established by using experimental design techniques that permitted independent analyses regardless of growth. This model system design was compared to real biofilms and was adapted to mimic the mechanical properties of biofilms by changing the hydrogel composition, resulting in biofilm-like viscoelastic behavior. The use of a gellan-based hydrogel enables the imitation of biofilm behavior in the absence of growth effects, thus simplifying the system. Biofilm characterization tools can be tested and verified before their application to the measurement of slow-growing, highly variable biofilms to estimate system errors, which are often smaller than the biological variations. In general, this method permits faster and more reliable testing of biofilm mechanical properties.
文摘针对轨道弹条扣件断裂率较高的问题,使用ABAQUS进行有限元分析,计算弹条的应力分布和位移变化情况。为提高弹条优化分析效率,采用正交数组试验设计(design of experiments,DOE),获得对弹条性能影响较大的几何参数。基于Isight平台集成SolidWorks和ABAQUS,利用Python编写仿真流程脚本。在标准安装约束下,以几何参数为设计变量,以弹条优化指标为目标函数,对弹条进行优化设计。结果表明:优化后,弹条质量减少2.1%,最大应力减小9.1%,弹条优化指标提高12.3%,弹条性能提升且在相同弹程下,扣压力满足标准要求,可为弹条设计提供参考。
文摘为解决某型脉冲增压柴油机第8缸排温高以及排温不均匀问题,基于GT-power仿真软件建立了柴油机仿真模型,利用多试验设计(design of experiments,DOE)实验设计方法对排气管结构进行了优化设计。结果表明,DOE方法可以辨识出结构参数和排气温度之间的映射关系,在Optimizer优化控制器可以快速得出最优的结构参数组合,优化后的排气管解决了第8缸排温高的问题,同时有效改善了各缸排温不均匀性。
文摘目前海上风机基础结构存在明显的设计冗余,导致海上风机建造成本过高。为提高经济效益,需要对导管架式海上风机基础结构进行优化设计。该文首先基于海上实测数据对海上风机所处环境载荷进行模拟,得到其时间历程;其次通过有限元方法对平箱梁四桩导管架式海上风机基础结构进行强度校核,发现结构可进行轻量化处理;最后以结构最大平均应力、最大位移和质量为目标响应,通过试验设计(design of experiments,DOE)方法和粒子群算法组合的优化方法,得到结构尺寸对结构目标响应的贡献度和主效应关系,并确定各结构最优尺寸。对海上风机基础结构进行优化设计,能在保证安全的前提下降低建造成本,可为后续海上风机基础结构设计建造提供参数参考。
