Objective：To investigate the effect of Fufang Danshen pill on bone marrow stem mobilization during myocardial scathe. Methods：Rat models with expansionary myocardial disease were established by Pituitrin and Furazol...Objective：To investigate the effect of Fufang Danshen pill on bone marrow stem mobilization during myocardial scathe. Methods：Rat models with expansionary myocardial disease were established by Pituitrin and Furazolidone. Experimental rats were divided into the contrast group, the myocardial scathe group （MS group）, the myocardial scathe and Fufang Dansben pill group （ MS ＋ FD group） and the myocardial scathe and fluvastatin group （ MS ＋ FT group）. The ratio of CD34^＋ cells was examined at the 1^st, 3^nl and 6^th weekend. Index of heart structure and function including LVESD, LVEDD. LYEF, LVEDP and dp/dtmax were evaluated at the 6^th weekend. The HW/BW index was calculated. Results：In the MS group, the index of HW/BW, LVESD, LVEDD and LVEDP were obviously increased （P 〈 0.01 ） and index of dp/ dtmax and LVEF were obviously decreased （P 〈 0.05 ）. The ratio of CD34^＋ cells was significantly improved at the 1^at weekend and then reduced slowly with no difference from that of the contrast group at the 6th weekend. Compared the MS ＋ FD group and the MS ＋ FT group with the MS group, the index of HW/BW, LYESD, LYEDD and LYEDP of were signifi cantly decreased （ P 〈 0.05 ） and index of dp/dtmax and LVEF were increased （P 〈 0.01 ）. The ratio of CD34^＋ cells was significantly higher at the 1^st, 3^nl and 6^th weekend, but had no statistic meaning at 3^nl and 6^th weekend （P 〉 0.05 ）. Conclusion：Pituitrin and Furazolidone can be used to establish rat models with expansionary myocardial disease. There has bone marrow stem mobilization during the early period of myocardial scathe. Fufang Danshen pill has effect on improving bone marrow stem mobilization, lightening the expansionary degree of heart and protecting the heart function. The effect of Fufang Danshen pill is as same as that of fluvastatin.展开更多
All governments face increasingly frequent issues arising from aggregate supply and demand against currency circulation and financial stability,and public finance and banking authorities employ a variety of policy ins...All governments face increasingly frequent issues arising from aggregate supply and demand against currency circulation and financial stability,and public finance and banking authorities employ a variety of policy instruments to keep the economy stable and coordinated.How to avoid policy conflicts and maximize effectiveness in policy portfolio of local government borrowing,which is taken as a major macro-control instrument,is a subject that needs in-depth study.This paper probes into local government borrowing’s monetary effect and transmission mechanism and its best synergistic model with monetary policy by the construction of a NK-DSGE model covering financial frictions,multi-period bonds and borrowing rules.The findings are as follows.(1)The shocks of one-percent local government borrowing(bond duration=5 years)push up the money multiplier by 0.39%to produce expansionary monetary effect,and the longer the bond duration,the greater the effect.(2)In the context of physical and financial shocks,monetary policy adopts a moderately tight reverse synergy with local government borrowing,effectively restraining its expansionary monetary effect for better economic stability and recovery.(3)For bonds with longer maturities,raising the risk sensitivity of local government borrowing rules benefits the improvement of welfare.展开更多
文摘Objective：To investigate the effect of Fufang Danshen pill on bone marrow stem mobilization during myocardial scathe. Methods：Rat models with expansionary myocardial disease were established by Pituitrin and Furazolidone. Experimental rats were divided into the contrast group, the myocardial scathe group （MS group）, the myocardial scathe and Fufang Dansben pill group （ MS ＋ FD group） and the myocardial scathe and fluvastatin group （ MS ＋ FT group）. The ratio of CD34^＋ cells was examined at the 1^st, 3^nl and 6^th weekend. Index of heart structure and function including LVESD, LVEDD. LYEF, LVEDP and dp/dtmax were evaluated at the 6^th weekend. The HW/BW index was calculated. Results：In the MS group, the index of HW/BW, LVESD, LVEDD and LVEDP were obviously increased （P 〈 0.01 ） and index of dp/ dtmax and LVEF were obviously decreased （P 〈 0.05 ）. The ratio of CD34^＋ cells was significantly improved at the 1^at weekend and then reduced slowly with no difference from that of the contrast group at the 6th weekend. Compared the MS ＋ FD group and the MS ＋ FT group with the MS group, the index of HW/BW, LYESD, LYEDD and LYEDP of were signifi cantly decreased （ P 〈 0.05 ） and index of dp/dtmax and LVEF were increased （P 〈 0.01 ）. The ratio of CD34^＋ cells was significantly higher at the 1^st, 3^nl and 6^th weekend, but had no statistic meaning at 3^nl and 6^th weekend （P 〉 0.05 ）. Conclusion：Pituitrin and Furazolidone can be used to establish rat models with expansionary myocardial disease. There has bone marrow stem mobilization during the early period of myocardial scathe. Fufang Danshen pill has effect on improving bone marrow stem mobilization, lightening the expansionary degree of heart and protecting the heart function. The effect of Fufang Danshen pill is as same as that of fluvastatin.
基金“Measurement and Optimizing Mechanism of Fiscal Resource Allocation Efficiency under Constraints of Tax&Fee Cuts and Debt Expansion”,a Humanities and Social Sciences General Research Program of the Ministry of Education(20YJA790046)“Transformation Mechanism of Local Government Debt Risk from the Perspective of Public Finance and Banking Synergy”,a Social Science General Research Program of Sichuan Province(SC22B047).
文摘All governments face increasingly frequent issues arising from aggregate supply and demand against currency circulation and financial stability,and public finance and banking authorities employ a variety of policy instruments to keep the economy stable and coordinated.How to avoid policy conflicts and maximize effectiveness in policy portfolio of local government borrowing,which is taken as a major macro-control instrument,is a subject that needs in-depth study.This paper probes into local government borrowing’s monetary effect and transmission mechanism and its best synergistic model with monetary policy by the construction of a NK-DSGE model covering financial frictions,multi-period bonds and borrowing rules.The findings are as follows.(1)The shocks of one-percent local government borrowing(bond duration=5 years)push up the money multiplier by 0.39%to produce expansionary monetary effect,and the longer the bond duration,the greater the effect.(2)In the context of physical and financial shocks,monetary policy adopts a moderately tight reverse synergy with local government borrowing,effectively restraining its expansionary monetary effect for better economic stability and recovery.(3)For bonds with longer maturities,raising the risk sensitivity of local government borrowing rules benefits the improvement of welfare.
