AIM: To investigate the association of lysyl oxidaselike 1(LOXL1) single nucleotide polymorphisms(SNPs)with exfoliation syndrome(XFS)/exfoliation glaucoma(XFG).METHODS: Published manuscripts from Pub Med and EMBASE we...AIM: To investigate the association of lysyl oxidaselike 1(LOXL1) single nucleotide polymorphisms(SNPs)with exfoliation syndrome(XFS)/exfoliation glaucoma(XFG).METHODS: Published manuscripts from Pub Med and EMBASE were identified until May 2014. Summary odds ratios(ORs) and 95% confidence intervals(CIs) for LOXL1(rs1048661, rs2165241 and rs3825942) polymorphisms and the risk of XFS/XFG were estimated using random-or fixed- effect model.· RESULTS: The three LOXL1 polymorphisms(rs1048661, rs3825942, and rs2165241) were associated with an increased risk for XFS/XFG among Caucasians,with OR 2.19(1.96-2.45), 8.8(6.05-12.79) and 3.41(3.11-3.73), respectively. On the contrast, the rs1048661 and rs2165241, but not rs3825942 polymorphism, have a potential protective effect on XFS/XFG in Asians, with OR0.06(0.02-0.18), 0.15(0.09-0.25), respectively.CONCLUSION: There is strong evidence that LOXL1 polymorphisms are associated with XFS/XFG risk. The strength of risk might be ethnicity-dependent.展开更多
目的:虹膜色素剥脱综合征(XFS)和剥脱性青光眼(XFG)患者与对照组血清维生素D水平比较。方法:使用液相色谱法测量25羟基维生素D血清水平。记录性别、年龄、高血压、糖尿病和缺血性心脏病病史等可变因素。结果:研究包括55例XFS/XFG患者和...目的:虹膜色素剥脱综合征(XFS)和剥脱性青光眼(XFG)患者与对照组血清维生素D水平比较。方法:使用液相色谱法测量25羟基维生素D血清水平。记录性别、年龄、高血压、糖尿病和缺血性心脏病病史等可变因素。结果:研究包括55例XFS/XFG患者和正常对照组60例。XFS/XFG患者较为年长(平均年龄:71.8y vs 67.5y,P=0.002)。两组性别分布相似且糖尿病、高血压和缺血性心脏病的患病率无显著性差异。XFS/XFG患者平均维生素D水平为14.7 ng/mL,正常对照组为14.9 ng/mL,两组间无显著性差异。虽然XFS/XFG组维生素D水平较低,但在对年龄、性别和医疗条件进行校正后,多变量分析显示两组之间维生素D缺乏无显著差异。结论:XFS/XFG组和正常对照组维生素D水平均较低,而XFS/XFG组低于正常对照组,两组间无明显差异。XFS和维生素D缺乏症与某些系统性疾病有共同联系。展开更多
基金Supported by Natural Science Foundation of Guangdong Province(No.S2013010016037)the National Science and Tecnology Plan Project of China(973 program,No.2011CB707501)
文摘AIM: To investigate the association of lysyl oxidaselike 1(LOXL1) single nucleotide polymorphisms(SNPs)with exfoliation syndrome(XFS)/exfoliation glaucoma(XFG).METHODS: Published manuscripts from Pub Med and EMBASE were identified until May 2014. Summary odds ratios(ORs) and 95% confidence intervals(CIs) for LOXL1(rs1048661, rs2165241 and rs3825942) polymorphisms and the risk of XFS/XFG were estimated using random-or fixed- effect model.· RESULTS: The three LOXL1 polymorphisms(rs1048661, rs3825942, and rs2165241) were associated with an increased risk for XFS/XFG among Caucasians,with OR 2.19(1.96-2.45), 8.8(6.05-12.79) and 3.41(3.11-3.73), respectively. On the contrast, the rs1048661 and rs2165241, but not rs3825942 polymorphism, have a potential protective effect on XFS/XFG in Asians, with OR0.06(0.02-0.18), 0.15(0.09-0.25), respectively.CONCLUSION: There is strong evidence that LOXL1 polymorphisms are associated with XFS/XFG risk. The strength of risk might be ethnicity-dependent.
文摘目的:虹膜色素剥脱综合征(XFS)和剥脱性青光眼(XFG)患者与对照组血清维生素D水平比较。方法:使用液相色谱法测量25羟基维生素D血清水平。记录性别、年龄、高血压、糖尿病和缺血性心脏病病史等可变因素。结果:研究包括55例XFS/XFG患者和正常对照组60例。XFS/XFG患者较为年长(平均年龄:71.8y vs 67.5y,P=0.002)。两组性别分布相似且糖尿病、高血压和缺血性心脏病的患病率无显著性差异。XFS/XFG患者平均维生素D水平为14.7 ng/mL,正常对照组为14.9 ng/mL,两组间无显著性差异。虽然XFS/XFG组维生素D水平较低,但在对年龄、性别和医疗条件进行校正后,多变量分析显示两组之间维生素D缺乏无显著差异。结论:XFS/XFG组和正常对照组维生素D水平均较低,而XFS/XFG组低于正常对照组,两组间无明显差异。XFS和维生素D缺乏症与某些系统性疾病有共同联系。
