A minor diterpenoid with a novel carbon skeleton,secoeuphoractin（1）,was isolated from an ethanol extract of the roots of Euphorbia micractina.Its structure including the absolute configuration was determined by exte...A minor diterpenoid with a novel carbon skeleton,secoeuphoractin（1）,was isolated from an ethanol extract of the roots of Euphorbia micractina.Its structure including the absolute configuration was determined by extensive spectroscopic studies,especially by 2D NMR and CD data analysis,in combination with a plausible biosynthetic pathway associated with co-occurring diverse diterpenoids.This compound showed activity against HIV-1 replication with an IC_（50） value of 1.76 ± 0.61 μmol/L.展开更多
利用正相硅胶柱层析、葡聚糖凝胶Sephadex LH-20、制备薄层层析、反相制备色谱等离手段和1H、13C NMR等波谱技术,从泽漆(Euphorbia helioscopiaL.)中分离鉴定了10个化合物,分别为β-谷甾醇(-βsitosterol,1),大戟甘(euphorn in,2),大戟...利用正相硅胶柱层析、葡聚糖凝胶Sephadex LH-20、制备薄层层析、反相制备色谱等离手段和1H、13C NMR等波谱技术,从泽漆(Euphorbia helioscopiaL.)中分离鉴定了10个化合物,分别为β-谷甾醇(-βsitosterol,1),大戟甘(euphorn in,2),大戟甘D(euphorn in D,3),A(euphohelioscop in A,4),槲皮素(quercetin,5),没食子酸(gallic ac id,6),咖啡酸(caffe ic ac id,7),没食子酸乙酯(ethyl gallate,8),杨梅素(myrecetin,9),金丝桃苷(hypero-side,10),其中化合物7、8、9是首次从该植物中分得,通过体外抗肿瘤活性研究,化合物6和10作为泽漆的抗肿瘤活性成分属首次报道。展开更多
基金Financial support from the National Natural Science Foundation of China(NNSFCNos.21172266 and 30825044)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT,No.IRT1007)the National Science and Technology Project of China(No.2012ZX09301002-002)
文摘A minor diterpenoid with a novel carbon skeleton,secoeuphoractin（1）,was isolated from an ethanol extract of the roots of Euphorbia micractina.Its structure including the absolute configuration was determined by extensive spectroscopic studies,especially by 2D NMR and CD data analysis,in combination with a plausible biosynthetic pathway associated with co-occurring diverse diterpenoids.This compound showed activity against HIV-1 replication with an IC_（50） value of 1.76 ± 0.61 μmol/L.
文摘利用正相硅胶柱层析、葡聚糖凝胶Sephadex LH-20、制备薄层层析、反相制备色谱等离手段和1H、13C NMR等波谱技术,从泽漆(Euphorbia helioscopiaL.)中分离鉴定了10个化合物,分别为β-谷甾醇(-βsitosterol,1),大戟甘(euphorn in,2),大戟甘D(euphorn in D,3),A(euphohelioscop in A,4),槲皮素(quercetin,5),没食子酸(gallic ac id,6),咖啡酸(caffe ic ac id,7),没食子酸乙酯(ethyl gallate,8),杨梅素(myrecetin,9),金丝桃苷(hypero-side,10),其中化合物7、8、9是首次从该植物中分得,通过体外抗肿瘤活性研究,化合物6和10作为泽漆的抗肿瘤活性成分属首次报道。
