Antibacterial effect of cinnamon oil combined with thyme or clove oil was studied in this paper. Agar dilution method was used to determine the minimum inhibitory concentrations （MICs） of the essential oils （EOs） ...Antibacterial effect of cinnamon oil combined with thyme or clove oil was studied in this paper. Agar dilution method was used to determine the minimum inhibitory concentrations （MICs） of the essential oils （EOs） of cinnamon, thyme, and clove oil against three Gram-positive bacteria （Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus）, and two Gramnegative bacteria （Escherichia coli and Salmonella typhimurium）. The results showed that cinnamon was a promising antibacterial substance with MIC ranged from 0.1 to 0.4 μL mL^-1 for the five bacterial species. Agar dilution checkerboard method was used to test the combined antibacterial effect of cinnamon oil with thyme or clove oil. Combination of cinnamon and thyme oil showed an additive effect against all selected bacteria, and combination of cinnamon and clove oil displayed an additive effect against B. subtilis, B. cereus, S. aureus, and an indifferent effect against E. coli and S. typhimurium. Furthermore, gas chromatography-mass spectrometry （GC-MS） measurement was used to analyze the components of the EOs, and the main components of cinnamon, thyme, and clove were cinnamaldehyde, thymol, carvacrol and p-cymene, and eugenol, respectively.展开更多
目的观察缬沙坦联合苯磺酸氨氯地平治疗原发性高血压的疗效。方法选取2013年1月~2014年1月我院住院治疗80例原发性高血压患者,依据随机数字表法分为观察组和对照组,每组各40例。对照组予缬沙坦80 mg,每天1次,口服;观察组同时联合苯磺酸...目的观察缬沙坦联合苯磺酸氨氯地平治疗原发性高血压的疗效。方法选取2013年1月~2014年1月我院住院治疗80例原发性高血压患者,依据随机数字表法分为观察组和对照组,每组各40例。对照组予缬沙坦80 mg,每天1次,口服;观察组同时联合苯磺酸氨氯地平5 mg,每天1次,口服;服药2周后,如血压达到130/80 mm Hg以下,或收缩压（SBP）下降20 mm Hg,或舒张压（DBP）下降10 mm Hg,则继续服药;反之,则增加药物剂量,苯磺酸氨氯地平增至10 mg/d,缬沙坦增至160 mg/d。连用4周。观察两组患者治疗前后SBP、DBP的变化,并进行临床疗效比较。结果治疗4周后,观察组的总有效率为95.0%,明显高于对照组的77.5%,差异有统计学意义（χ2=6.327,P〈0.05）。两组患者的SBP、DBP水平均显著降低,且观察组SBP、DBP水平较对照组降低更明显,差异有统计学意义（P〈0.05）。结论缬沙坦联合苯磺酸氨氯地平应用可以提高原发性高血压的疗效,有效降低血压水平,安全性好,值得推广应用。展开更多
基金supported by the National High-Tech R&D Program of China (863 Program)(SQ2007AA10XK140105)the Zhejiang Province Key Scientific and Technological Project, China(2006C12051)the Zhejiang Provincial Center for Disease Control and Prevention (CDC) (Hangzhou,China)
文摘Antibacterial effect of cinnamon oil combined with thyme or clove oil was studied in this paper. Agar dilution method was used to determine the minimum inhibitory concentrations （MICs） of the essential oils （EOs） of cinnamon, thyme, and clove oil against three Gram-positive bacteria （Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus）, and two Gramnegative bacteria （Escherichia coli and Salmonella typhimurium）. The results showed that cinnamon was a promising antibacterial substance with MIC ranged from 0.1 to 0.4 μL mL^-1 for the five bacterial species. Agar dilution checkerboard method was used to test the combined antibacterial effect of cinnamon oil with thyme or clove oil. Combination of cinnamon and thyme oil showed an additive effect against all selected bacteria, and combination of cinnamon and clove oil displayed an additive effect against B. subtilis, B. cereus, S. aureus, and an indifferent effect against E. coli and S. typhimurium. Furthermore, gas chromatography-mass spectrometry （GC-MS） measurement was used to analyze the components of the EOs, and the main components of cinnamon, thyme, and clove were cinnamaldehyde, thymol, carvacrol and p-cymene, and eugenol, respectively.
文摘目的观察缬沙坦联合苯磺酸氨氯地平治疗原发性高血压的疗效。方法选取2013年1月~2014年1月我院住院治疗80例原发性高血压患者,依据随机数字表法分为观察组和对照组,每组各40例。对照组予缬沙坦80 mg,每天1次,口服;观察组同时联合苯磺酸氨氯地平5 mg,每天1次,口服;服药2周后,如血压达到130/80 mm Hg以下,或收缩压（SBP）下降20 mm Hg,或舒张压（DBP）下降10 mm Hg,则继续服药;反之,则增加药物剂量,苯磺酸氨氯地平增至10 mg/d,缬沙坦增至160 mg/d。连用4周。观察两组患者治疗前后SBP、DBP的变化,并进行临床疗效比较。结果治疗4周后,观察组的总有效率为95.0%,明显高于对照组的77.5%,差异有统计学意义（χ2=6.327,P〈0.05）。两组患者的SBP、DBP水平均显著降低,且观察组SBP、DBP水平较对照组降低更明显,差异有统计学意义（P〈0.05）。结论缬沙坦联合苯磺酸氨氯地平应用可以提高原发性高血压的疗效,有效降低血压水平,安全性好,值得推广应用。
