【目的】探讨国际抗癫痫联盟(International League Aganst Epilepsy,ILAE)2001年癫痫分类建议的临床应用;分析各类癫痫诱发因素,病因、癫痫类型在门诊癫痫病例中的分布。【方法】按ILAF2001年的建议对门诊癫痫病例进行调查分析。【结...【目的】探讨国际抗癫痫联盟(International League Aganst Epilepsy,ILAE)2001年癫痫分类建议的临床应用;分析各类癫痫诱发因素,病因、癫痫类型在门诊癫痫病例中的分布。【方法】按ILAF2001年的建议对门诊癫痫病例进行调查分析。【结果】局限性发作1 256例,全面性发作442例,继发性癫痫129例,不能分类63例。存在诱发因素者308例,继发性癫痫病因以脑出血、脑梗死及脑肿瘤占多数。【结论】ILAF2001年的建议中增加的内容包括了预防、诊断及治疗等方面,使癫痫分类诊断更完善,对于临床具有重要影响和实际意义。展开更多
国际抗癫痫联盟(International League Against Epilepsy,ILAE)分类和术语委员会2010年制定的发作和癫痫分类框架术语及概念修订版旨在进一步建立和规范发作和癫痫分类术语及概念的国际共识,反映术语与分类的基本关系,以指导临床实践,...国际抗癫痫联盟(International League Against Epilepsy,ILAE)分类和术语委员会2010年制定的发作和癫痫分类框架术语及概念修订版旨在进一步建立和规范发作和癫痫分类术语及概念的国际共识,反映术语与分类的基本关系,以指导临床实践,尤其是指导制定更合适的治疗方案。对于以往的全面性发作和局灶性发作分类法,目前强调依据网络的起源方式重新进行定义,其中双侧起源为全面性发作,局限于一侧为局灶性发作。此外,建议使用遗传性、结构性/代谢性和未知病因这3个术语以替代原来的特发性、症状性和隐源性。新的报告还首次使用了一些特定的术语,如电-临床综合征、相对明确的癫痫群体和癫痫性脑病等。本文对ILAE关于发作和癫痫分类框架术语及概念最新修订版进行了解读。展开更多
Background: Moderate to severe hypoxic-ischemic encephalopathy (HIE) in neonates is often treated with hypothermia. However, some neonates may experience epileptic seizures during therapeutic hypothermia (TH). Data on...Background: Moderate to severe hypoxic-ischemic encephalopathy (HIE) in neonates is often treated with hypothermia. However, some neonates may experience epileptic seizures during therapeutic hypothermia (TH). Data on the electrophysiologic and evolutionary aspects of these seizures are scarce in African countries. Objectives: To determine the types of epileptic seizures caused by HIE in neonates in Brazzaville;to describe the evolution of background EEG activities during TH and rewarming;to report the evolution of epileptic seizures. Methods: This was a cross-sectional, descriptive study conducted from January 2020 to July 2022. It took place in Brazzaville in the Neonatology Department of the Blanche Gomez Mother and Child Hospital. It focused on term neonates suffering from moderate or severe HIE. They were treated with hypothermia combined with phenobarbital for 72 hours. Results: Among 36 neonates meeting inclusion criteria, there were 18 boys and 18 girls. Thirty-one (86.1%) neonates had grade 2 and 5 (13.9%) grade 3 HIE. In our neonates, HIE had induced isolated electrographic seizures (n = 11;30.6%), electroclinical seizures (n = 25;69.4%), and 6 types of background EEG activity. During TH and rewarming, there were 52.8% of patients with improved background EEG activity, 41.7% of patients with unchanged background EEG activity, and 5.5% of patients with worsened background EEG activity. At the end of rewarming, only 9 (25%) patients still had seizures. Conclusion: Isolated electrographic and electroclinical seizures are the only pathological entities found in our studied population. In neonates with moderate HIE, the applied therapeutic strategy positively influences the evolution of both seizures and background EEG activity. On the other hand, in neonates with severe HIE, the same therapeutic strategy is ineffective. .展开更多
文摘【目的】探讨国际抗癫痫联盟(International League Aganst Epilepsy,ILAE)2001年癫痫分类建议的临床应用;分析各类癫痫诱发因素,病因、癫痫类型在门诊癫痫病例中的分布。【方法】按ILAF2001年的建议对门诊癫痫病例进行调查分析。【结果】局限性发作1 256例,全面性发作442例,继发性癫痫129例,不能分类63例。存在诱发因素者308例,继发性癫痫病因以脑出血、脑梗死及脑肿瘤占多数。【结论】ILAF2001年的建议中增加的内容包括了预防、诊断及治疗等方面,使癫痫分类诊断更完善,对于临床具有重要影响和实际意义。
文摘国际抗癫痫联盟(International League Against Epilepsy,ILAE)分类和术语委员会2010年制定的发作和癫痫分类框架术语及概念修订版旨在进一步建立和规范发作和癫痫分类术语及概念的国际共识,反映术语与分类的基本关系,以指导临床实践,尤其是指导制定更合适的治疗方案。对于以往的全面性发作和局灶性发作分类法,目前强调依据网络的起源方式重新进行定义,其中双侧起源为全面性发作,局限于一侧为局灶性发作。此外,建议使用遗传性、结构性/代谢性和未知病因这3个术语以替代原来的特发性、症状性和隐源性。新的报告还首次使用了一些特定的术语,如电-临床综合征、相对明确的癫痫群体和癫痫性脑病等。本文对ILAE关于发作和癫痫分类框架术语及概念最新修订版进行了解读。
文摘Background: Moderate to severe hypoxic-ischemic encephalopathy (HIE) in neonates is often treated with hypothermia. However, some neonates may experience epileptic seizures during therapeutic hypothermia (TH). Data on the electrophysiologic and evolutionary aspects of these seizures are scarce in African countries. Objectives: To determine the types of epileptic seizures caused by HIE in neonates in Brazzaville;to describe the evolution of background EEG activities during TH and rewarming;to report the evolution of epileptic seizures. Methods: This was a cross-sectional, descriptive study conducted from January 2020 to July 2022. It took place in Brazzaville in the Neonatology Department of the Blanche Gomez Mother and Child Hospital. It focused on term neonates suffering from moderate or severe HIE. They were treated with hypothermia combined with phenobarbital for 72 hours. Results: Among 36 neonates meeting inclusion criteria, there were 18 boys and 18 girls. Thirty-one (86.1%) neonates had grade 2 and 5 (13.9%) grade 3 HIE. In our neonates, HIE had induced isolated electrographic seizures (n = 11;30.6%), electroclinical seizures (n = 25;69.4%), and 6 types of background EEG activity. During TH and rewarming, there were 52.8% of patients with improved background EEG activity, 41.7% of patients with unchanged background EEG activity, and 5.5% of patients with worsened background EEG activity. At the end of rewarming, only 9 (25%) patients still had seizures. Conclusion: Isolated electrographic and electroclinical seizures are the only pathological entities found in our studied population. In neonates with moderate HIE, the applied therapeutic strategy positively influences the evolution of both seizures and background EEG activity. On the other hand, in neonates with severe HIE, the same therapeutic strategy is ineffective. .
