The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, bu...The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://birthdefectlab.cn:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.展开更多
During the coronavirus disease 2019 (COVID-19) emergency, many hospitals were built or renovated around the world to meet the challenges posed by the rising number of infected cases. Environmental management in the ho...During the coronavirus disease 2019 (COVID-19) emergency, many hospitals were built or renovated around the world to meet the challenges posed by the rising number of infected cases. Environmental management in the hospital life cycle is vital in preventing nosocomial infection and includes many infection control procedures. In certain urgent situations, a hospital must be completed quickly, and work process approval and supervision must therefore be accelerated. Thus, many works cannot be checked in detail. This results in a lack of work liability control and increases the difficulty of ensuring the fulfillment of key infection prevention measures. This study investigates how blockchain technology can transform the work quality inspection workflow to assist in nosocomial infection control under a fast delivery requirement. A blockchain-based life-cycle environmental management framework is proposed to track the fulfillment of crucial infection control measures in the design, construction, and operation stages of hospitals. The proposed framework allows for work quality checking after the work is completed, when some work cannot be checked on time. Illustrative use cases are selected to demonstrate the capabilities of the developed solution. This study provides new insights into applying blockchain technology to address the challenge of environmental management brought by rapid delivery requirements.展开更多
Honeybees (Apis mellifera) have haplodiploid sex determination: males develop from unfertilized eggs and females develop from fertilized ones. The differences in larval food also determine the development of females. ...Honeybees (Apis mellifera) have haplodiploid sex determination: males develop from unfertilized eggs and females develop from fertilized ones. The differences in larval food also determine the development of females. Here we compared the total somatic gene expression profiles of 2-day and 4-day-old drone, queen and worker larvae by RNASeq. The results from a co-expression network analysis on all expressed genes showed that 2-day-old drone and worker larvae were closer in gene expression profiles than 2-day-old queen larvae. This indicated that for young larvae (2-day-old) environmental factors such as larval diet have a greater effect on gene expression profiles than ploidy or sex determination. Drones had the most distinct gene expression profiles at the 4-day larval stage, suggesting that haploidy, or sex dramatically affects the gene expression of honeybee larvae. Drone larvae showed fewer differences in gene expression profiles at the 2-day and 4-day time points than the worker and queen larval comparisons (598 against 1190 and 1181), suggesting a different pattern of gene expression regulation during the larval development of haploid males compared to diploid females. This study indicates that early in development the queen caste has the most distinct gene expression profile, perhaps reflecting the very rapid growth and morphological specialization of this caste compared to workers and drones. Later in development the haploid male drones have the most distinct gene expression profile, perhaps reflecting the influence of ploidy or sex determination on gene expression.展开更多
The influence of origin, depositional environment and thermal maturity of organic matter on the occurrence of aromatic hydrocarbons in source rocks from the central and northwestern Niger Delta was investigated. Eight...The influence of origin, depositional environment and thermal maturity of organic matter on the occurrence of aromatic hydrocarbons in source rocks from the central and northwestern Niger Delta was investigated. Eighty two source rock samples from four oil wells in the central and northwestern Niger Delta were analyzed for the aromatic hydrocarbon content using gas chromatography-mass spectrometry (GC-MS). The results of analysis of aromatic hydrocarbon fractions of the source rock extracts show the presence of many classes of aromatic hydrocarbons, which include naphthalenes, phenanthrenes, biphenyls, dibenzothiophenes and fluorenes. Trimethylnaphthalene (TMN) is the most abundant among the naphthalenes while dimethylphenanthrene (DMP) is the most abundant among the phenanthrenes. Among the biphenyls, 3-methylbiphenyl (3 MB) is the most abundant while 4-methyldibenzothiophene (4MDBT) is the most abundant among the dibenzothiphenes. Only two fluorenes were detected, and fluorene is more in abundance than 1-methylfluorene (1 MF). Depositional environment indicators of aromatic hydrocarbon organic matter reveal that the organic materials in the source rocks in these wells were deposited in marine-to-swamp depositional environments under reducing to suboxic conditions. Thermal maturity indicators calculated from the abundance of the aromatic hydrocarbons indicate that the source rock samples are thermally mature. Most of the source rocks are at the peak of oil window while a few at the early oil window. Source rocks from wells GB, OP and OT in the central Niger Delta are thermally more mature than those from well AW in the northwestern Niger Delta.展开更多
Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gathere...Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gatherer as a case study,this paper makes an argument that the behaviors of the villagers in the story can be more adequately interpreted in view of the backward countryside environment,and the same is true with the author Richard Jefferies' non-interference in the omniscient third-person point of view in writing the story.It is Richard Jefferies' family environment that makes up his viewpoint of writing,reflecting his critical loving of the countryside,where lives boom and conventions are extremely followed.展开更多
Nantong Jiangshan Agrochemical & ChemicalCo.,Ltd.(SH:600389)posted the sales rose 18.95% in 2008 from a year earlier to RMB3.23billion,driven by higher sales volume and increas-ing prices of glyphosate in the firs...Nantong Jiangshan Agrochemical & ChemicalCo.,Ltd.(SH:600389)posted the sales rose 18.95% in 2008 from a year earlier to RMB3.23billion,driven by higher sales volume and increas-ing prices of glyphosate in the first half of 2008,and higher sales for chemical products.Sales forits pesticide business alone gained 64.9% toRMB1.83 billion.The company’s net profit surged 175.91% toRMB302 million.EPS was RMB1.52.The government’s efforts to improve environ-mental protection standards is set to give a展开更多
Chengdu of Sichuan province is actively promoting the work on energy conservation and emission reduction.Huaneng Chengdu Power Plant and 44 small cement plants have already been closed.
20082233 Bai Bin(Department of Geology, Northwest University,Xi’an 710069, China);Yang Wenjing Sediment Provenance Analysis and Tectonic Setting Discrimination of Shanxi Formation on West Edge of Ordos Basin(Coal Geo...20082233 Bai Bin(Department of Geology, Northwest University,Xi’an 710069, China);Yang Wenjing Sediment Provenance Analysis and Tectonic Setting Discrimination of Shanxi Formation on West Edge of Ordos Basin(Coal Geology & Exploration。展开更多
The 5G mobile Internet facilitates contents generation for online communities and platforms through human-to-human collaboration.Wikipedia,a well-known online community,uses wiki technology to build an encyclopedia th...The 5G mobile Internet facilitates contents generation for online communities and platforms through human-to-human collaboration.Wikipedia,a well-known online community,uses wiki technology to build an encyclopedia through collective intelligence and collaboration.Mainstream wiki systems adopt a centralized implementation,and while existing studies have optimized the efficiency of the wiki systems'centralized implementation,these systems still suffer from a lot of problems,for example,opacity and distrust.Over the years,blockchain has brought a flurry of fervour and decentralization to the system architecture,meanwhile giving users a sense of trust and participation.Thus,an innovative blockchain-enabled wiki framework called DecWiki is proposed to build one transparent,truthful,collaborative and autonomous encyclopedia.After several participatory design iterations,we present DecWiki's detailed architecture and its implementation in the form of a smart contract and use the interplanetary file system to complement the big data storage.Meanwhile,we use the trusted execution environment to secure sensitive information in the wireless scenario.Finally,the system overhead and the acceptance of the prototype are evaluated.Extensive experiments present its significant performance.展开更多
基金funded by the Shanghai Hospital Development Center(SHDC2020CR6028-002 to W.Zhou)National Key R&D Program of China(2020YFC2006402 to Y.Lu)+7 种基金National Key R&D Program of China(2022ZD0116003 to X.Dong)the Science and Technology Commission of Shanghai(22002400700 to S.Wu)Shanghai Municipal Science and Technology Major Project(20Z11900600 to W.Zhou)National Key Research and Development Program(2018YFC0116903 to W.Zhou)Major Research Projects for Young and Middle-aged People of Fujian Province(2021ZQNZD017 to Y.Lu)supported by Key Lab Information Network Security,Ministry of Public Security(to H.Zheng and S.Wang)“Pioneer”and”Leading Goose”R&D Program of Zhejiang(No.2022C01126 to Q.Sun and S.Wang)National Key R&D Program of China(2021YFC2500802 and 2021YFC2500806 to H.Zheng and S.Wang).
文摘The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://birthdefectlab.cn:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.
基金supported by the National Natural Science Foundation of China(71732001,51878311,72271106,U21A20151,and 71821001)Engineering Fronts Project(2021-HYZD-5-13)+1 种基金Major Science&Technology Project of Hubei(2020ACA006)China Scholarship Council(202006160115).
文摘During the coronavirus disease 2019 (COVID-19) emergency, many hospitals were built or renovated around the world to meet the challenges posed by the rising number of infected cases. Environmental management in the hospital life cycle is vital in preventing nosocomial infection and includes many infection control procedures. In certain urgent situations, a hospital must be completed quickly, and work process approval and supervision must therefore be accelerated. Thus, many works cannot be checked in detail. This results in a lack of work liability control and increases the difficulty of ensuring the fulfillment of key infection prevention measures. This study investigates how blockchain technology can transform the work quality inspection workflow to assist in nosocomial infection control under a fast delivery requirement. A blockchain-based life-cycle environmental management framework is proposed to track the fulfillment of crucial infection control measures in the design, construction, and operation stages of hospitals. The proposed framework allows for work quality checking after the work is completed, when some work cannot be checked on time. Illustrative use cases are selected to demonstrate the capabilities of the developed solution. This study provides new insights into applying blockchain technology to address the challenge of environmental management brought by rapid delivery requirements.
文摘Honeybees (Apis mellifera) have haplodiploid sex determination: males develop from unfertilized eggs and females develop from fertilized ones. The differences in larval food also determine the development of females. Here we compared the total somatic gene expression profiles of 2-day and 4-day-old drone, queen and worker larvae by RNASeq. The results from a co-expression network analysis on all expressed genes showed that 2-day-old drone and worker larvae were closer in gene expression profiles than 2-day-old queen larvae. This indicated that for young larvae (2-day-old) environmental factors such as larval diet have a greater effect on gene expression profiles than ploidy or sex determination. Drones had the most distinct gene expression profiles at the 4-day larval stage, suggesting that haploidy, or sex dramatically affects the gene expression of honeybee larvae. Drone larvae showed fewer differences in gene expression profiles at the 2-day and 4-day time points than the worker and queen larval comparisons (598 against 1190 and 1181), suggesting a different pattern of gene expression regulation during the larval development of haploid males compared to diploid females. This study indicates that early in development the queen caste has the most distinct gene expression profile, perhaps reflecting the very rapid growth and morphological specialization of this caste compared to workers and drones. Later in development the haploid male drones have the most distinct gene expression profile, perhaps reflecting the influence of ploidy or sex determination on gene expression.
文摘The influence of origin, depositional environment and thermal maturity of organic matter on the occurrence of aromatic hydrocarbons in source rocks from the central and northwestern Niger Delta was investigated. Eighty two source rock samples from four oil wells in the central and northwestern Niger Delta were analyzed for the aromatic hydrocarbon content using gas chromatography-mass spectrometry (GC-MS). The results of analysis of aromatic hydrocarbon fractions of the source rock extracts show the presence of many classes of aromatic hydrocarbons, which include naphthalenes, phenanthrenes, biphenyls, dibenzothiophenes and fluorenes. Trimethylnaphthalene (TMN) is the most abundant among the naphthalenes while dimethylphenanthrene (DMP) is the most abundant among the phenanthrenes. Among the biphenyls, 3-methylbiphenyl (3 MB) is the most abundant while 4-methyldibenzothiophene (4MDBT) is the most abundant among the dibenzothiphenes. Only two fluorenes were detected, and fluorene is more in abundance than 1-methylfluorene (1 MF). Depositional environment indicators of aromatic hydrocarbon organic matter reveal that the organic materials in the source rocks in these wells were deposited in marine-to-swamp depositional environments under reducing to suboxic conditions. Thermal maturity indicators calculated from the abundance of the aromatic hydrocarbons indicate that the source rock samples are thermally mature. Most of the source rocks are at the peak of oil window while a few at the early oil window. Source rocks from wells GB, OP and OT in the central Niger Delta are thermally more mature than those from well AW in the northwestern Niger Delta.
文摘Human living environment interacts with human behaviors.Environment to some degree determines human behaviors which in return reshape and sustain the dynamic environment.Taking Richard Jefferies' The Acorn Gatherer as a case study,this paper makes an argument that the behaviors of the villagers in the story can be more adequately interpreted in view of the backward countryside environment,and the same is true with the author Richard Jefferies' non-interference in the omniscient third-person point of view in writing the story.It is Richard Jefferies' family environment that makes up his viewpoint of writing,reflecting his critical loving of the countryside,where lives boom and conventions are extremely followed.
文摘Nantong Jiangshan Agrochemical & ChemicalCo.,Ltd.(SH:600389)posted the sales rose 18.95% in 2008 from a year earlier to RMB3.23billion,driven by higher sales volume and increas-ing prices of glyphosate in the first half of 2008,and higher sales for chemical products.Sales forits pesticide business alone gained 64.9% toRMB1.83 billion.The company’s net profit surged 175.91% toRMB302 million.EPS was RMB1.52.The government’s efforts to improve environ-mental protection standards is set to give a
文摘Chengdu of Sichuan province is actively promoting the work on energy conservation and emission reduction.Huaneng Chengdu Power Plant and 44 small cement plants have already been closed.
文摘20082233 Bai Bin(Department of Geology, Northwest University,Xi’an 710069, China);Yang Wenjing Sediment Provenance Analysis and Tectonic Setting Discrimination of Shanxi Formation on West Edge of Ordos Basin(Coal Geology & Exploration。
基金supported by the National Natural Science Foundation of China(NSFC)under Grant No.61932007.
文摘The 5G mobile Internet facilitates contents generation for online communities and platforms through human-to-human collaboration.Wikipedia,a well-known online community,uses wiki technology to build an encyclopedia through collective intelligence and collaboration.Mainstream wiki systems adopt a centralized implementation,and while existing studies have optimized the efficiency of the wiki systems'centralized implementation,these systems still suffer from a lot of problems,for example,opacity and distrust.Over the years,blockchain has brought a flurry of fervour and decentralization to the system architecture,meanwhile giving users a sense of trust and participation.Thus,an innovative blockchain-enabled wiki framework called DecWiki is proposed to build one transparent,truthful,collaborative and autonomous encyclopedia.After several participatory design iterations,we present DecWiki's detailed architecture and its implementation in the form of a smart contract and use the interplanetary file system to complement the big data storage.Meanwhile,we use the trusted execution environment to secure sensitive information in the wireless scenario.Finally,the system overhead and the acceptance of the prototype are evaluated.Extensive experiments present its significant performance.
