There is a growing body of evidence showing that periaqueductal gray (PAG) and nucleus accumbens (N. accumbens) play important roles in the modulation of nociception. In our previous study of the mechanisms of morphin...There is a growing body of evidence showing that periaqueductal gray (PAG) and nucleus accumbens (N. accumbens) play important roles in the modulation of nociception. In our previous study of the mechanisms of morphine analgesia we found that opioid antagonist naloxone injected into either of the two nuclei, PAG or N. accumbens, could展开更多
Acupuncture is a traditional therapeutic technique in Oriental medicine,which has a long history of 4000 years. As a modern version of hand acupuncture,electroacupuncture (EA) can provide a valid analgesic effect and ...Acupuncture is a traditional therapeutic technique in Oriental medicine,which has a long history of 4000 years. As a modern version of hand acupuncture,electroacupuncture (EA) can provide a valid analgesic effect and has little physiological interference. It was successfully used to ameliorate pain not only in varieties of painful diseases,but in various operations,such as cesarean section,gastrectomy,enterectomy and castration,in animals during the 1970s. Since then,analgesia-regulating mechanism of EA has been extensively investigated. Previous studies found that electroacupuncture analgesia (EAA) was involved in modulations of neurotransmitters or neuromodulators in the central nerve system (CNS),and most early studies focused on the role of neurotransmitters such as serotonin,noradrenaline, dopamine and acetylcholine. Later,it was certified that some endogenous opioid peptides (EOPs),mainly including enkephalin,β-endorphin and dynorphin,played a more important role in EAA. EA of different frequencies can promote the release of different EOPs in the CNS. Studies showed that EAA induced by 2 Hz (low frequency) was mediated by the release of met-enkephalin (M-ENK) and β-endorphin (β-EP),while EAA by 100 Hz (high frequency) was mediated by the release of dynorphin-A (DYN-A) in the CNS in rats. Although these results in rats above are extrapolated to give reasonable explanations for acupuncture analgesia phenomenon and its treatment of related diseases in human,there are still some unknown mechanisms to be investigated. It has been proved that analgesia induced by EA varies in animal species. In order to quantitatively estimate the degree of acupuncture-induced analgesia,some researchers used an anesthetic to ensure a complete analgesia and to assess the reduction of the amount of the anesthetics consumed in the EA plus anesthetic group as compared to the anesthetic group without acupuncture. Studies showed EA in combination with anesthetics resulted in the reduction of the dosage of the anesthetics in human,ra展开更多
The present is aimed at the effects of electro-acupuncture (EA) on endogenous opioidpeptides’ (EPOs) contents in the aged rat brain and pituitary in order to further expound the anti-ag-ing mechanism of acupuncture. ...The present is aimed at the effects of electro-acupuncture (EA) on endogenous opioidpeptides’ (EPOs) contents in the aged rat brain and pituitary in order to further expound the anti-ag-ing mechanism of acupuncture. The results show that the 5-endorphin (5-EP) contents in the aged rathypothalamus and pituitary are significantly higher than those in the young rats and lower in hippocampus, and leuenkephalin (LEK) levels are also higher in the aged rat hippocampus and striatumthan those in the young rats. In the aged rats that received the EA stimulations, the β-EP contents inthe hypothalamus, pituitary, and the LEK level in the striatum are decreased sigrijficantly and the β-EP contents is increased in the hippocampus, The results suggest that the aging delaying effects ofacupuncture may be reached partly through modifying the age-related changes of EOPs’ secretion inthe rat brain and pituitary.展开更多
文摘There is a growing body of evidence showing that periaqueductal gray (PAG) and nucleus accumbens (N. accumbens) play important roles in the modulation of nociception. In our previous study of the mechanisms of morphine analgesia we found that opioid antagonist naloxone injected into either of the two nuclei, PAG or N. accumbens, could
文摘Acupuncture is a traditional therapeutic technique in Oriental medicine,which has a long history of 4000 years. As a modern version of hand acupuncture,electroacupuncture (EA) can provide a valid analgesic effect and has little physiological interference. It was successfully used to ameliorate pain not only in varieties of painful diseases,but in various operations,such as cesarean section,gastrectomy,enterectomy and castration,in animals during the 1970s. Since then,analgesia-regulating mechanism of EA has been extensively investigated. Previous studies found that electroacupuncture analgesia (EAA) was involved in modulations of neurotransmitters or neuromodulators in the central nerve system (CNS),and most early studies focused on the role of neurotransmitters such as serotonin,noradrenaline, dopamine and acetylcholine. Later,it was certified that some endogenous opioid peptides (EOPs),mainly including enkephalin,β-endorphin and dynorphin,played a more important role in EAA. EA of different frequencies can promote the release of different EOPs in the CNS. Studies showed that EAA induced by 2 Hz (low frequency) was mediated by the release of met-enkephalin (M-ENK) and β-endorphin (β-EP),while EAA by 100 Hz (high frequency) was mediated by the release of dynorphin-A (DYN-A) in the CNS in rats. Although these results in rats above are extrapolated to give reasonable explanations for acupuncture analgesia phenomenon and its treatment of related diseases in human,there are still some unknown mechanisms to be investigated. It has been proved that analgesia induced by EA varies in animal species. In order to quantitatively estimate the degree of acupuncture-induced analgesia,some researchers used an anesthetic to ensure a complete analgesia and to assess the reduction of the amount of the anesthetics consumed in the EA plus anesthetic group as compared to the anesthetic group without acupuncture. Studies showed EA in combination with anesthetics resulted in the reduction of the dosage of the anesthetics in human,ra
文摘The present is aimed at the effects of electro-acupuncture (EA) on endogenous opioidpeptides’ (EPOs) contents in the aged rat brain and pituitary in order to further expound the anti-ag-ing mechanism of acupuncture. The results show that the 5-endorphin (5-EP) contents in the aged rathypothalamus and pituitary are significantly higher than those in the young rats and lower in hippocampus, and leuenkephalin (LEK) levels are also higher in the aged rat hippocampus and striatumthan those in the young rats. In the aged rats that received the EA stimulations, the β-EP contents inthe hypothalamus, pituitary, and the LEK level in the striatum are decreased sigrijficantly and the β-EP contents is increased in the hippocampus, The results suggest that the aging delaying effects ofacupuncture may be reached partly through modifying the age-related changes of EOPs’ secretion inthe rat brain and pituitary.
