Cytochrome P4501A(CYP1A),one of the major CYP subfamily in humans,not only metabolizes xenobiotics including clinical drugs and pollutants in the environment,but also mediates the bio transformation of important endog...Cytochrome P4501A(CYP1A),one of the major CYP subfamily in humans,not only metabolizes xenobiotics including clinical drugs and pollutants in the environment,but also mediates the bio transformation of important endogenous substances.In particular,some single nucleotide polymorphisms(SNPs)for CYPIA genes may affect the metabolic ability of endogenous substances,leading to some physiological or pathological changes in humans.This review first summarizes the metabolism of endogenous substances by CYPIA,and then introduces the research progress of CYPIA SNPs,especially the research related to human diseases.Finally,the relationship between SNPs and diseases is discussed.In addition,potential animal models for CYPIA gene editing are summarized.In conclusion,CYP1A plays an important role in maintaining the health in the body.展开更多
Estrogen and progesterone receptor (ER and PR) contents of 40 breastcancer patients were determined with immunofluorescent staining.Thedifferentiation of cancer cells was evaluated on the basis of histological andultr...Estrogen and progesterone receptor (ER and PR) contents of 40 breastcancer patients were determined with immunofluorescent staining.Thedifferentiation of cancer cells was evaluated on the basis of histological andultrastructural changes.It was found that there was a positive correlation of ERand PR contents with the cellular differentiation of breast cancer,and the lattercould be used to estimate the status of hormone receptors.Breast cancer is a malignant disease with heteropathological characteristics.In handling a breast cancerpatient,both the status of hormone receptors and the cellular differentiationshould be considered and the treatment varied with each pa(?)ent.For those witha well-differentiated cancer and rich hormone receptors,endocrine therapy shouldmainly be administered,while for those with a poorly-differentiated cancer and afew hormone receptors,chemotherapy would be of choice.展开更多
基金supported in part by grants from the National Natural Science Foundation of China(No.81773808)the Science and Technology Commission of Shanghai Municipality(Nos.17140901000,17140901001 and 18430760400,China).
文摘Cytochrome P4501A(CYP1A),one of the major CYP subfamily in humans,not only metabolizes xenobiotics including clinical drugs and pollutants in the environment,but also mediates the bio transformation of important endogenous substances.In particular,some single nucleotide polymorphisms(SNPs)for CYPIA genes may affect the metabolic ability of endogenous substances,leading to some physiological or pathological changes in humans.This review first summarizes the metabolism of endogenous substances by CYPIA,and then introduces the research progress of CYPIA SNPs,especially the research related to human diseases.Finally,the relationship between SNPs and diseases is discussed.In addition,potential animal models for CYPIA gene editing are summarized.In conclusion,CYP1A plays an important role in maintaining the health in the body.
文摘Estrogen and progesterone receptor (ER and PR) contents of 40 breastcancer patients were determined with immunofluorescent staining.Thedifferentiation of cancer cells was evaluated on the basis of histological andultrastructural changes.It was found that there was a positive correlation of ERand PR contents with the cellular differentiation of breast cancer,and the lattercould be used to estimate the status of hormone receptors.Breast cancer is a malignant disease with heteropathological characteristics.In handling a breast cancerpatient,both the status of hormone receptors and the cellular differentiationshould be considered and the treatment varied with each pa(?)ent.For those witha well-differentiated cancer and rich hormone receptors,endocrine therapy shouldmainly be administered,while for those with a poorly-differentiated cancer and afew hormone receptors,chemotherapy would be of choice.
