This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet count.Despite notable findings,significant methodological and interpretat...This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet count.Despite notable findings,significant methodological and interpretative limitations are identified.The study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold values.The nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with cirrhosis.Moreover,the study's limitations,such as selection bias and confounding factors,are not adequately addressed.Future research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability.展开更多
本文复习采用压力-容积关系研究心室工作性能的现状。目前关于收缩末期压力-容积关系(ESPVR)的实验和临床研究大多声称采用“随时间变化的容积弹回率最大值(Emax)”,而实际测定“收缩末期容积弹回率(Ees)”,作为评价心脏收缩性的指标。...本文复习采用压力-容积关系研究心室工作性能的现状。目前关于收缩末期压力-容积关系(ESPVR)的实验和临床研究大多声称采用“随时间变化的容积弹回率最大值(Emax)”,而实际测定“收缩末期容积弹回率(Ees)”,作为评价心脏收缩性的指标。然而最近的资料表明,ESPVR 可能是非线性的、后负荷依赖性的,具有测量变异性,因此,试图将压力-容积关系简化为单一 Ees 指标是不适当的。反之,采用扩大的观点,即考虑压力-容积关系所含有的全部信息,这一方法可评价心功能以及心脏与血管系统的相互作用。展开更多
文摘This letter critically evaluates Jiang et al's article on the differentiation of benign and malignant liver lesions using Emax and platelet count.Despite notable findings,significant methodological and interpretative limitations are identified.The study lacks detailed assay conditions for Emax measurement,employs inadequate statistical methods without robust multivariate analysis,and does not provide clinically relevant threshold values.The nomogram's reliance on Emax as a major diagnostic contributor is questionable due to attenuation in hepatocellular carcinoma patients with cirrhosis.Moreover,the study's limitations,such as selection bias and confounding factors,are not adequately addressed.Future research should adopt more rigorous methodologies,including prospective studies with larger cohorts and standardized protocols for biomarker measurement,to enhance validity and clinical applicability.
文摘本文复习采用压力-容积关系研究心室工作性能的现状。目前关于收缩末期压力-容积关系(ESPVR)的实验和临床研究大多声称采用“随时间变化的容积弹回率最大值(Emax)”,而实际测定“收缩末期容积弹回率(Ees)”,作为评价心脏收缩性的指标。然而最近的资料表明,ESPVR 可能是非线性的、后负荷依赖性的,具有测量变异性,因此,试图将压力-容积关系简化为单一 Ees 指标是不适当的。反之,采用扩大的观点,即考虑压力-容积关系所含有的全部信息,这一方法可评价心功能以及心脏与血管系统的相互作用。
