There are still controversies about the roles of microRNA-26a（miR-26a）in human malignancies,as it is a tumor suppressor in breast cancer,gastric cancer,and hepatocellular carcinoma,but is an oncogene in glioma and c...There are still controversies about the roles of microRNA-26a（miR-26a）in human malignancies,as it is a tumor suppressor in breast cancer,gastric cancer,and hepatocellular carcinoma,but is an oncogene in glioma and cholangiocarcinoma.Until now,the function of miR-26a in osteosarcoma remains largely elusive.Here,we found that miR-26a was downregualted in osteosarcoma tissues.Using in vitro and in vivo assays,we confirmed that miR-26a could inhibit the abilities of in vitro proliferation and suppress in vivo tumor growth in mouse model.Furthermore,we identified insulin-like growth factor 1（IGF-1）as a novel and direct target of miR-26a and revealed that miR-26a exerted its tumor-suppressor function,at least in part,by inhibiting IGF-1expression.These findings contribute to our understanding of the functions of miR-26a in osteosarcoma.展开更多
A graph property is a set of graphs such that if the set contains some graph G then it also contains each isomorphic copy of G (with the same vertex set). A graph property P on n ventices is said to be elusive, if eve...A graph property is a set of graphs such that if the set contains some graph G then it also contains each isomorphic copy of G (with the same vertex set). A graph property P on n ventices is said to be elusive, if every decision tree algorithm recognizing P must examine all n(n - 1)/2 pairs of ventices in the worst case. Karp conjectured that every nontrivial monotone graph property is elusive. In this paper, this conjecture is proved for some cases. Especially,it is shown that if the abstract simplicial complex of a nontrivial monotone graph property P has dimension not exceeding 5, then P is elusive.展开更多
Diseases of the nervous system are characterized by axon dysfunction,axon degeneration,and neuronal cell death.The roster of neurodegenerative diseases is striking in the selective vulnerability of the affected neuron...Diseases of the nervous system are characterized by axon dysfunction,axon degeneration,and neuronal cell death.The roster of neurodegenerative diseases is striking in the selective vulnerability of the affected neuronal populations and the timing of the onset of disease manifestation and functional deficits.展开更多
Mafic dike swarms are well-developed within the Tethyan Himalaya,southern Tibet,in response to the breakup of Gondwana supercontinent,seafloor spreading of the Tethyan Ocean,and forearc hyperextension during the
Creative nonfiction is coming of age, not simply as opposed to ficdon, but as respectable as good ficdon true to its name. Due attention should be drawn to this super-genre absorbing varied subject matter. This paper ...Creative nonfiction is coming of age, not simply as opposed to ficdon, but as respectable as good ficdon true to its name. Due attention should be drawn to this super-genre absorbing varied subject matter. This paper looks into creative nonfiction as a form of art with a let-its-hair-down attitude generally in line with the genre. Creative nonfiction is held to be a paradoxically generic term covering subcategories such as memoir, biography, autobiography, history, and journalism. Instead of being walled off from one another, these subcategories mix and match to build up a work of truth, or rather elusive truth, which might sound stranger than fiction. In addition to the imaginative mix and match to open up new possibilities for writing, felicity of style is another add-on to doing it well. Hence creative nonfiction is conceived as an adventure to wrap up a somewhat strange story in a serendipitous form as well as a felicitous language. Hopefully, this three- quarter profile of the genre will be able to offer a thin slice of the picture to the audience.展开更多
This inspiring story reminds us that well-rounded success in business, family, and community need not be elusive,especially when diligence, imagination, and love are inabundance.
THE August announcement by the UN Security Council authorizing an additional interven- tion force of 4,000 troops to South Sudan has given some hope to the war-torn country. The mandate of this force to protect civili...THE August announcement by the UN Security Council authorizing an additional interven- tion force of 4,000 troops to South Sudan has given some hope to the war-torn country. The mandate of this force to protect civilians and help bolster the tenuous peace process, despite practical deployment challenges, will be tested in the months ahead.展开更多
文摘There are still controversies about the roles of microRNA-26a（miR-26a）in human malignancies,as it is a tumor suppressor in breast cancer,gastric cancer,and hepatocellular carcinoma,but is an oncogene in glioma and cholangiocarcinoma.Until now,the function of miR-26a in osteosarcoma remains largely elusive.Here,we found that miR-26a was downregualted in osteosarcoma tissues.Using in vitro and in vivo assays,we confirmed that miR-26a could inhibit the abilities of in vitro proliferation and suppress in vivo tumor growth in mouse model.Furthermore,we identified insulin-like growth factor 1（IGF-1）as a novel and direct target of miR-26a and revealed that miR-26a exerted its tumor-suppressor function,at least in part,by inhibiting IGF-1expression.These findings contribute to our understanding of the functions of miR-26a in osteosarcoma.
文摘A graph property is a set of graphs such that if the set contains some graph G then it also contains each isomorphic copy of G (with the same vertex set). A graph property P on n ventices is said to be elusive, if every decision tree algorithm recognizing P must examine all n(n - 1)/2 pairs of ventices in the worst case. Karp conjectured that every nontrivial monotone graph property is elusive. In this paper, this conjecture is proved for some cases. Especially,it is shown that if the abstract simplicial complex of a nontrivial monotone graph property P has dimension not exceeding 5, then P is elusive.
基金supported,in part,by NIH/NEI grants EY019949 and EY025061American Diabetes Association Research Grant#7-11-BS-182an Unrestricted Grant to the Department of Ophthalmology,SUNY-Buffalo,from Research to Prevent Blindness
文摘Diseases of the nervous system are characterized by axon dysfunction,axon degeneration,and neuronal cell death.The roster of neurodegenerative diseases is striking in the selective vulnerability of the affected neuronal populations and the timing of the onset of disease manifestation and functional deficits.
基金supported by National Science Foundation of China (Grant No. 41425010, 41503023 &41273034)China Geological Survey (Grant No. 12120114022701 & 12120115027101)
文摘Mafic dike swarms are well-developed within the Tethyan Himalaya,southern Tibet,in response to the breakup of Gondwana supercontinent,seafloor spreading of the Tethyan Ocean,and forearc hyperextension during the
文摘Creative nonfiction is coming of age, not simply as opposed to ficdon, but as respectable as good ficdon true to its name. Due attention should be drawn to this super-genre absorbing varied subject matter. This paper looks into creative nonfiction as a form of art with a let-its-hair-down attitude generally in line with the genre. Creative nonfiction is held to be a paradoxically generic term covering subcategories such as memoir, biography, autobiography, history, and journalism. Instead of being walled off from one another, these subcategories mix and match to build up a work of truth, or rather elusive truth, which might sound stranger than fiction. In addition to the imaginative mix and match to open up new possibilities for writing, felicity of style is another add-on to doing it well. Hence creative nonfiction is conceived as an adventure to wrap up a somewhat strange story in a serendipitous form as well as a felicitous language. Hopefully, this three- quarter profile of the genre will be able to offer a thin slice of the picture to the audience.
文摘This inspiring story reminds us that well-rounded success in business, family, and community need not be elusive,especially when diligence, imagination, and love are inabundance.
文摘THE August announcement by the UN Security Council authorizing an additional interven- tion force of 4,000 troops to South Sudan has given some hope to the war-torn country. The mandate of this force to protect civilians and help bolster the tenuous peace process, despite practical deployment challenges, will be tested in the months ahead.
