确定和安排运动负荷是运动训练过程核心和基础性的内容之一,也是体医融合领域重要的关键技术。研究通过数理逻辑分析和建模,基于不确定性科学,提出了一种运动负荷熵测度理论,构建了相应测定系统,并组织实施了151 958次试验。分析发现,1...确定和安排运动负荷是运动训练过程核心和基础性的内容之一,也是体医融合领域重要的关键技术。研究通过数理逻辑分析和建模,基于不确定性科学,提出了一种运动负荷熵测度理论,构建了相应测定系统,并组织实施了151 958次试验。分析发现,1834年德国生理学家恩斯特·海因里希·韦伯(Ernst Heinrich Weber)提出的最小可觉差的观点并不完善。研究证明运动刺激的感知阈限并不是一个固定值,且韦伯分数也不是一个常数,而是会随着参考负荷的增加而降低的系数。经数理推导和实验验证,研究建立了运动负荷主客体统一的测度方程,研究成果为个体化精确运动负荷测度提供了新方法。展开更多
Objective To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. Design Multicenter, double-blind, placebo-controlled, parall... Objective To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. Design Multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial of 216 sta- ble outpatients with HF, ejection fraction ≥ 50%, elevated N-terminal brain-type natriuretic peptide or elevat- ed invasively measured filling pressures, and reduced exercise capacity. Participants were randomized from October 2008 through February 2012 at 26 centers in North America. Follow-up was through August 30, 2012.展开更多
Exercise has long been known for its active role in improving physical fitness and sustaining health.Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative an...Exercise has long been known for its active role in improving physical fitness and sustaining health.Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various diseases.It is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological conditions.Here we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and regeneration.Furthermore,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to exercise.This review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health interventions.We hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life.展开更多
文摘确定和安排运动负荷是运动训练过程核心和基础性的内容之一,也是体医融合领域重要的关键技术。研究通过数理逻辑分析和建模,基于不确定性科学,提出了一种运动负荷熵测度理论,构建了相应测定系统,并组织实施了151 958次试验。分析发现,1834年德国生理学家恩斯特·海因里希·韦伯(Ernst Heinrich Weber)提出的最小可觉差的观点并不完善。研究证明运动刺激的感知阈限并不是一个固定值,且韦伯分数也不是一个常数,而是会随着参考负荷的增加而降低的系数。经数理推导和实验验证,研究建立了运动负荷主客体统一的测度方程,研究成果为个体化精确运动负荷测度提供了新方法。
文摘 Objective To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. Design Multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial of 216 sta- ble outpatients with HF, ejection fraction ≥ 50%, elevated N-terminal brain-type natriuretic peptide or elevat- ed invasively measured filling pressures, and reduced exercise capacity. Participants were randomized from October 2008 through February 2012 at 26 centers in North America. Follow-up was through August 30, 2012.
基金Among these,patents were licensed to Bayer(WO2014020041-A1 and WO2014020043-A1)Bristol-Myers Squibb(WO2008057863-A1)+4 种基金Osasuna Therapeutics(WO2019057742A1)Pharmamar(WO2022049270A1 and WO2022048775-A1)Raptor Pharmaceuticals(EP2664326-A1)Samsara Therapeutics(GB202017553D0)Therafast Bio(EP3684471A1).The other authors declare that they have no competing interests.
文摘Exercise has long been known for its active role in improving physical fitness and sustaining health.Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various diseases.It is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological conditions.Here we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and regeneration.Furthermore,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to exercise.This review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health interventions.We hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life.
