Objective To investigate the effect of urate-lowering therapy on renal function in chroinc kidney disease(CKD)stages 2-5 patients with hyperuricemia(HUA).Methods A total of 132 patients of CKD stages 2-5 with HUA betw...Objective To investigate the effect of urate-lowering therapy on renal function in chroinc kidney disease(CKD)stages 2-5 patients with hyperuricemia(HUA).Methods A total of 132 patients of CKD stages 2-5 with HUA between July 2016 and December 2017 in Department of Nephrology of the Second Affiliated Hospital of Anhui Medical University were prospectively and self-controlled analyzed.Serum uric acid(SUA),estimated glomerular filtration rate(eGFR)and other clinical parameters were measured at baseline and after 1-6 months'treatment.The patients were divided into group A(CKD stages 2-2a)and group B(CKD stages 3b-5)on the baseline value of eGFR.The changes of SUA and eGFR before and after treatment were compared.According to the level of SUA after 6 months treatment,the patients were divided into attainment group(SUA<360 μmol/L)and nonattainment group(SUA≥360 μmol/L).The difference of renal function in pretreatment and post-treatment was compared.Multiple stepwise linear regression was used to analyze the relationship among the change of eGFR after receiving 6 months'treatment(deGFR)and SUA level,baseline eG-FR and other indexes.Results After 1,3,6 months'treatment,the average levels of SUA,Scr and urea nitrogen of all patients were decreased significantly while eGFR value was increased more significantly(all P<0.050)than those in pre-treatment period.After six-month-therapy,proteinuria and hematuria were improved significantly in all patients(P<0.001,P=0.001).Com-pared with pre-treatment period,both SUA levels of group A and group B were declined significantly while eGFR had a significant rise after treatment(P<0.001).The change of eGFR post-treatment in group A was significantly higher than that of group B [(13.64±15.35)vs(8.97±9.79)ml · min^-1·(1.73 m^2)^-1,P=0.044].6 months after treatment,the eGFR value increased markedly in both attainment group and nonattainment group compared with pre-treatment period(P<0.001).After six-month-therapy,the eGFR value in the attainment group was increased more obviously展开更多
文摘Objective To investigate the effect of urate-lowering therapy on renal function in chroinc kidney disease(CKD)stages 2-5 patients with hyperuricemia(HUA).Methods A total of 132 patients of CKD stages 2-5 with HUA between July 2016 and December 2017 in Department of Nephrology of the Second Affiliated Hospital of Anhui Medical University were prospectively and self-controlled analyzed.Serum uric acid(SUA),estimated glomerular filtration rate(eGFR)and other clinical parameters were measured at baseline and after 1-6 months'treatment.The patients were divided into group A(CKD stages 2-2a)and group B(CKD stages 3b-5)on the baseline value of eGFR.The changes of SUA and eGFR before and after treatment were compared.According to the level of SUA after 6 months treatment,the patients were divided into attainment group(SUA<360 μmol/L)and nonattainment group(SUA≥360 μmol/L).The difference of renal function in pretreatment and post-treatment was compared.Multiple stepwise linear regression was used to analyze the relationship among the change of eGFR after receiving 6 months'treatment(deGFR)and SUA level,baseline eG-FR and other indexes.Results After 1,3,6 months'treatment,the average levels of SUA,Scr and urea nitrogen of all patients were decreased significantly while eGFR value was increased more significantly(all P<0.050)than those in pre-treatment period.After six-month-therapy,proteinuria and hematuria were improved significantly in all patients(P<0.001,P=0.001).Com-pared with pre-treatment period,both SUA levels of group A and group B were declined significantly while eGFR had a significant rise after treatment(P<0.001).The change of eGFR post-treatment in group A was significantly higher than that of group B [(13.64±15.35)vs(8.97±9.79)ml · min^-1·(1.73 m^2)^-1,P=0.044].6 months after treatment,the eGFR value increased markedly in both attainment group and nonattainment group compared with pre-treatment period(P<0.001).After six-month-therapy,the eGFR value in the attainment group was increased more obviously
