目的探讨成人体质指数(body mass index,BMI)、腰围(waist circumference,WC)与高血压、糖尿病和血脂异常的关系。方法利用江苏省2010年成人慢性病及其危险因素监测数据,采用方差分析、偏相关和非条件Logistic回归模型研究BMI、WC与血...目的探讨成人体质指数(body mass index,BMI)、腰围(waist circumference,WC)与高血压、糖尿病和血脂异常的关系。方法利用江苏省2010年成人慢性病及其危险因素监测数据,采用方差分析、偏相关和非条件Logistic回归模型研究BMI、WC与血压、血糖、血脂、高血压、糖尿病和血脂异常的关系。结果调查人群新检出高血压、糖尿病和血脂异常患病率为35.3%、4.3%和28.4%。不同BMI、WC组间血压、血糖和血脂差异有统计学意义(均有P<0.05)。BMI、WC与收缩压、舒张压、空腹血糖、总胆固醇、甘油三酯和低密度脂蛋白胆固醇正相关,与高密度脂蛋白胆固醇负相关(均有P<0.05)。随着BMI和WC增加,高血压、糖尿病和血脂异常患病风险上升(均有P<0.05),且BMI、WC每增加1个标准差,高血压患病风险分别增加57%和58%,糖尿病增加53%和64%,血脂异常增加61%和67%。结论 BMI、WC与高血压、糖尿病和血脂异常密切相关,且WC对患病风险影响更大。展开更多
Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus(T2DM) and this appears to underlie the development of cardiovascular disease,T2 DM and diabetic complications.Increased oxidative stress...Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus(T2DM) and this appears to underlie the development of cardiovascular disease,T2 DM and diabetic complications.Increased oxidative stress appears to be a deleterious factor leading toinsulin resistance,dyslipidemia,β-cell dysfunction,impaired glucose tolerance and ultimately leading to T2 DM.Chronic oxidative stress,hyperglycemia and dyslipidemia are particularly dangerous for β-cells from lowest levels of antioxidant,have high oxidative energy requirements,decrease the gene expression of key β-cell genes and induce cell death.If β-cell functioning is impaired,it results in an under production of insulin,impairs glucose stimulated insulin secretion,fasting hyperglycemia and eventually the development of T2 DM.展开更多
目的基于网络药理学方法分析枳术丸治疗血脂异常的药理机制,为新药研发及经典方剂临床拓展运用提供参考。方法通过TCMSP(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform)数据库获取白术、枳实、荷...目的基于网络药理学方法分析枳术丸治疗血脂异常的药理机制,为新药研发及经典方剂临床拓展运用提供参考。方法通过TCMSP(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform)数据库获取白术、枳实、荷叶的主要化学成分及其靶点,根据ADME筛选中药活性组分;通过Gencards、OMIM、TTD、DRUGBANK数据库获取血脂异常主要靶点,利用String平台进行蛋白质相互作用分析,构建PPI网络并挖掘网络中潜在的蛋白质功能模块。采用Metascape平台分析"药物-成分-靶点"及其参与的生物过程及通路,而后采用Cytoscape3.7.1软件构建"枳术丸成分-血脂异常靶点-通路"网络,最后通过Systems Dock Web Site进行分子对接验证。结果枳术丸调治血脂异常的核心活性成分为槲皮素、山柰酚、木犀草素、柚皮素等,核心靶点有ESR1、NOS2、ESR2、PPARG、PTGS2、PTGS1、MAPK14、ACHE、ADRB2、F7等,分子对接验证亦显示评分大于4.25者占总数85%,大于5者占63.6%,即大部分靶点与成分的结合活性较好。枳术丸调治血脂异常的生物学通路主要作用于AGE-RAGE信号通路、HIF-1信号通路以及脂肪细胞中脂肪分解等通路,其功能主要为调节细胞内类固醇受体的生命活动等。结论本研究初步揭示了枳术丸调治血脂异常的多成分、多靶点、多通路的作用机制,为枳术丸的临床开发利用提供基础。展开更多
Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blo...Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required.展开更多
文摘目的探讨成人体质指数(body mass index,BMI)、腰围(waist circumference,WC)与高血压、糖尿病和血脂异常的关系。方法利用江苏省2010年成人慢性病及其危险因素监测数据,采用方差分析、偏相关和非条件Logistic回归模型研究BMI、WC与血压、血糖、血脂、高血压、糖尿病和血脂异常的关系。结果调查人群新检出高血压、糖尿病和血脂异常患病率为35.3%、4.3%和28.4%。不同BMI、WC组间血压、血糖和血脂差异有统计学意义(均有P<0.05)。BMI、WC与收缩压、舒张压、空腹血糖、总胆固醇、甘油三酯和低密度脂蛋白胆固醇正相关,与高密度脂蛋白胆固醇负相关(均有P<0.05)。随着BMI和WC增加,高血压、糖尿病和血脂异常患病风险上升(均有P<0.05),且BMI、WC每增加1个标准差,高血压患病风险分别增加57%和58%,糖尿病增加53%和64%,血脂异常增加61%和67%。结论 BMI、WC与高血压、糖尿病和血脂异常密切相关,且WC对患病风险影响更大。
文摘Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus(T2DM) and this appears to underlie the development of cardiovascular disease,T2 DM and diabetic complications.Increased oxidative stress appears to be a deleterious factor leading toinsulin resistance,dyslipidemia,β-cell dysfunction,impaired glucose tolerance and ultimately leading to T2 DM.Chronic oxidative stress,hyperglycemia and dyslipidemia are particularly dangerous for β-cells from lowest levels of antioxidant,have high oxidative energy requirements,decrease the gene expression of key β-cell genes and induce cell death.If β-cell functioning is impaired,it results in an under production of insulin,impairs glucose stimulated insulin secretion,fasting hyperglycemia and eventually the development of T2 DM.
文摘目的基于网络药理学方法分析枳术丸治疗血脂异常的药理机制,为新药研发及经典方剂临床拓展运用提供参考。方法通过TCMSP(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform)数据库获取白术、枳实、荷叶的主要化学成分及其靶点,根据ADME筛选中药活性组分;通过Gencards、OMIM、TTD、DRUGBANK数据库获取血脂异常主要靶点,利用String平台进行蛋白质相互作用分析,构建PPI网络并挖掘网络中潜在的蛋白质功能模块。采用Metascape平台分析"药物-成分-靶点"及其参与的生物过程及通路,而后采用Cytoscape3.7.1软件构建"枳术丸成分-血脂异常靶点-通路"网络,最后通过Systems Dock Web Site进行分子对接验证。结果枳术丸调治血脂异常的核心活性成分为槲皮素、山柰酚、木犀草素、柚皮素等,核心靶点有ESR1、NOS2、ESR2、PPARG、PTGS2、PTGS1、MAPK14、ACHE、ADRB2、F7等,分子对接验证亦显示评分大于4.25者占总数85%,大于5者占63.6%,即大部分靶点与成分的结合活性较好。枳术丸调治血脂异常的生物学通路主要作用于AGE-RAGE信号通路、HIF-1信号通路以及脂肪细胞中脂肪分解等通路,其功能主要为调节细胞内类固醇受体的生命活动等。结论本研究初步揭示了枳术丸调治血脂异常的多成分、多靶点、多通路的作用机制,为枳术丸的临床开发利用提供基础。
基金supported by the National Health and Family Planning Commission(formerly the Ministry of Health of the People’s Republic of China)Medical Reform Major Program:China Nutrition and Health Surveillance(2010-2012)and Chinese Adults Chronic Diseases and Nutrition Surveillance(2015)
文摘Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required.
