An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elonga...An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elongated to form tetra-and hexasaccharides followed by the introduction of anomeric groups via glycosylation couplings. A number of CS-E tetra-and hexasaccharide precursors were prepared in high yields.展开更多
基金supported by the CAMS Innovation Fund for Medical Sciences(Nos.CIFMS 2016-I2M-3-009 and CIFMS 2017I2M-3-011)
文摘An efficient and facile approach has been developed for the construction of chondroitin sulfate E(CS-E)oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GIcA sequence was first elongated to form tetra-and hexasaccharides followed by the introduction of anomeric groups via glycosylation couplings. A number of CS-E tetra-and hexasaccharide precursors were prepared in high yields.
