目的探讨3.0T磁共振弥散加权成像(DWI)结合液体衰减翻转恢复(FLAIR)序列、三维动脉自旋标记成像(3D ASL)双不匹配技术对不明发病时间急性脑梗死(ACI)患者的应用价值。方法选取我院进行3.0T磁共振DWI、FLAIR、3D ASL、磁共振血管成像(MRA...目的探讨3.0T磁共振弥散加权成像(DWI)结合液体衰减翻转恢复(FLAIR)序列、三维动脉自旋标记成像(3D ASL)双不匹配技术对不明发病时间急性脑梗死(ACI)患者的应用价值。方法选取我院进行3.0T磁共振DWI、FLAIR、3D ASL、磁共振血管成像(MRA)扫描的不明时间窗的急性脑梗死患者35例,并同时满足DWI高信号且FLAIR在相应的DWI高信号区未显影及DWI高信号、3D ASL存在灌注减低区且灌注减低区/DWI高信号区>1.2双不匹配,并存在大血管闭塞患者。同时选取明确发病时间窗内(<4.5 h)急性脑梗死患者35例,进行再灌注治疗。比较两组患者治疗前及治疗后24 h NIHSS评分、两组90 d mRS评分及颅内出血的发生率。结果双不匹配组与明确时间窗组治疗前后24 h NIHSS评分比较有显著性差异(P<0.05)。90 d mRS比较无显著性差异(P>0.05)。结论DWI-FLAIR、DWI-3D ASL双不匹配可作为不明发病时间急性脑梗死患者发病时间、缺血半暗带及再灌注情况的有效评估手段,为静脉溶栓、桥接治疗以及保守治疗提供依据。展开更多
In this work,two process-variation-tolerant schemes for a current-mode sense amplifier(CSA)of RRAM were proposed:(1)hybrid read reference generator(HRRG)that tracks process-voltage-temperature(PVT)variations and solve...In this work,two process-variation-tolerant schemes for a current-mode sense amplifier(CSA)of RRAM were proposed:(1)hybrid read reference generator(HRRG)that tracks process-voltage-temperature(PVT)variations and solve the nonlinear issue of the RRAM cells;(2)a two-stage offset-cancelled current sense amplifier(TSOCC-SA)with only two capacitors achieves a double sensing margin and a high tolerance of device mismatch.The simulation results in 28 nm CMOS technology show that the HRRG can provide a read reference that tracks PVT variations and solves the nonlinear issue of the RRAM cells.The proposed TSOCC-SA can tolerate over 64% device mismatch.展开更多
Objective:To investigate the clinical effects of applying the magnetic resonance double mismatch technique to endovascular treatment of acute anterior circulation,large vessel occlusion with cerebral infarction in an ...Objective:To investigate the clinical effects of applying the magnetic resonance double mismatch technique to endovascular treatment of acute anterior circulation,large vessel occlusion with cerebral infarction in an unknown time window.Methods:The research work was carried out in our hospital,the work was carried out from November 2018 to November 2019,the patients with acute anterior circulation large vessel occlusion with cerebral infarction who were treated in our hospital during this period,100 patients,50 patients with an unknown time window and 50 patients with definite time window were selected,and they were named as the experimental and control groups,given different examination methods,were given to investigate the clinical treatment effect.Results:Patients’data on HIHSS score before treatment,the incidence of intracranial hemorrhage and rate of Mrs≤2 rating after 90 days of treatment were not significantly different(P>0.05),which was not meaningful.The differences in data between the two groups concerning HIHSS scores were relatively significant before,and after treatment(P<0.05).Conclusion:The magnetic resonance double mismatch technique will be applied in the endovascular treatment of acute anterior circulation large vessel occlusion with cerebral infarction of unknown time window.展开更多
文摘目的探讨3.0T磁共振弥散加权成像(DWI)结合液体衰减翻转恢复(FLAIR)序列、三维动脉自旋标记成像(3D ASL)双不匹配技术对不明发病时间急性脑梗死(ACI)患者的应用价值。方法选取我院进行3.0T磁共振DWI、FLAIR、3D ASL、磁共振血管成像(MRA)扫描的不明时间窗的急性脑梗死患者35例,并同时满足DWI高信号且FLAIR在相应的DWI高信号区未显影及DWI高信号、3D ASL存在灌注减低区且灌注减低区/DWI高信号区>1.2双不匹配,并存在大血管闭塞患者。同时选取明确发病时间窗内(<4.5 h)急性脑梗死患者35例,进行再灌注治疗。比较两组患者治疗前及治疗后24 h NIHSS评分、两组90 d mRS评分及颅内出血的发生率。结果双不匹配组与明确时间窗组治疗前后24 h NIHSS评分比较有显著性差异(P<0.05)。90 d mRS比较无显著性差异(P>0.05)。结论DWI-FLAIR、DWI-3D ASL双不匹配可作为不明发病时间急性脑梗死患者发病时间、缺血半暗带及再灌注情况的有效评估手段,为静脉溶栓、桥接治疗以及保守治疗提供依据。
基金supported in part by the National Key R&D Program of China under Grant No.2019YFB2204800in part by the Major Scientific Research Project of Zhejiang Lab(Grant No.2019KC0AD02)+1 种基金in part by the National Natural Science Foundation of China under Grants 61904200the Strategic Priority Research Program of the Chinese Academy of Sciences under Grant No.XDB44000000。
文摘In this work,two process-variation-tolerant schemes for a current-mode sense amplifier(CSA)of RRAM were proposed:(1)hybrid read reference generator(HRRG)that tracks process-voltage-temperature(PVT)variations and solve the nonlinear issue of the RRAM cells;(2)a two-stage offset-cancelled current sense amplifier(TSOCC-SA)with only two capacitors achieves a double sensing margin and a high tolerance of device mismatch.The simulation results in 28 nm CMOS technology show that the HRRG can provide a read reference that tracks PVT variations and solves the nonlinear issue of the RRAM cells.The proposed TSOCC-SA can tolerate over 64% device mismatch.
文摘Objective:To investigate the clinical effects of applying the magnetic resonance double mismatch technique to endovascular treatment of acute anterior circulation,large vessel occlusion with cerebral infarction in an unknown time window.Methods:The research work was carried out in our hospital,the work was carried out from November 2018 to November 2019,the patients with acute anterior circulation large vessel occlusion with cerebral infarction who were treated in our hospital during this period,100 patients,50 patients with an unknown time window and 50 patients with definite time window were selected,and they were named as the experimental and control groups,given different examination methods,were given to investigate the clinical treatment effect.Results:Patients’data on HIHSS score before treatment,the incidence of intracranial hemorrhage and rate of Mrs≤2 rating after 90 days of treatment were not significantly different(P>0.05),which was not meaningful.The differences in data between the two groups concerning HIHSS scores were relatively significant before,and after treatment(P<0.05).Conclusion:The magnetic resonance double mismatch technique will be applied in the endovascular treatment of acute anterior circulation large vessel occlusion with cerebral infarction of unknown time window.
