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Review of Pathogen Identification and Diagnosis Technology of Pinewood Nematode Disease
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作者 ZHANG Kai LIANG Jun ZHANG Xingyao 《Chinese Forestry Science and Technology》 2007年第1期69-76,共8页
This article briefly introduced the disease incidence and disservice situation in China. The disease is regarded as cancer in pines for its higher spread and death speed and the difficulty in prevention. Strict quaran... This article briefly introduced the disease incidence and disservice situation in China. The disease is regarded as cancer in pines for its higher spread and death speed and the difficulty in prevention. Strict quarantine is the main measure on countrol of the disease, for there are many difficulties in the prevention. The most important part of the disease study is the early diagnosis and detection. 展开更多
关键词 pinewood nematod diseasee pine wilt disease Bursaphelenchus xylophilus PATHOGEN IDENTIFICATION DIAGNOSIS
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新疆维吾尔族与汉族冠心病冠状动脉造影对照研究 被引量:13
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作者 贾文霄 张其镍 +1 位作者 孙绪荣 顾玉兰 《中华放射学杂志》 CAS CSCD 北大核心 1994年第12期836-838,共3页
作者就113例选择性冠状动脉造影做一总结,将维吾尔族(29例)和汉族(74例)进行对照分析,发现新疆维吾尔族冠心病冠状动脉狭窄程度重,多支病变相对多,且以复杂性病变为主,心脏室壁瘤发生率高。
关键词 冠心病 冠状动脉造影 新疆 维吾尔族 诊断
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密骨煎防治去卵巢大鼠骨丢失的双能X线扫描观察 被引量:7
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作者 刘庆思 李小侬 +3 位作者 徐敏 何赞厚 林伟 叶广春 《广州中医学院学报》 1994年第4期223-225,共3页
以卵巢切除术制做绝经期后骨质疏松症大鼠模型,应用双能X线骨密度扫描技术动态观测该模型骨丢失的程度和灌服自拟中药密骨煎的防治作用,结果显示模型组术后8周与对照组比较有异常骨丢失(P<0.001);中药组骨丢失程度较模型... 以卵巢切除术制做绝经期后骨质疏松症大鼠模型,应用双能X线骨密度扫描技术动态观测该模型骨丢失的程度和灌服自拟中药密骨煎的防治作用,结果显示模型组术后8周与对照组比较有异常骨丢失(P<0.001);中药组骨丢失程度较模型组明显减轻(P(0.005);表明密骨煎对绝经期后骨质疏松症有防治作用。 展开更多
关键词 骨质疏松 中医药疗法 密骨煎 药理学 X线
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PICCO检测在肺心病合并心源性休克中的应用价值分析 被引量:8
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作者 董庆华 汤展宏 秦学斌 《重庆医学》 CAS 北大核心 2017年第23期3229-3230,3233,共3页
目的分析脉搏指示连续心输出量(PICCO)检测在慢性肺源性心脏病合并心源性休克中的应用价值。方法选择2014年1月至2015年3月该院收治的慢性肺源性心脏病合并心源性休克患者68例,分为研究组36例,对照组32例。两组均给予慢性肺源性心脏病... 目的分析脉搏指示连续心输出量(PICCO)检测在慢性肺源性心脏病合并心源性休克中的应用价值。方法选择2014年1月至2015年3月该院收治的慢性肺源性心脏病合并心源性休克患者68例,分为研究组36例,对照组32例。两组均给予慢性肺源性心脏病合并心源性休克常规治疗,对照组同时行深静脉穿刺监测患者中心静脉压(CVP)变化。研究组在常规监测基础上行深静脉置管+股动脉置管+PICCO监测。观察两组治疗效果及研究组治疗期间PICCO指标变化。结果研究组患者应用血管活性药物时间、住院时间、机械通气时间均显著低于对照组,差异有统计学意义(P<0.05),两组病死率比较差异无统计学意义(P>0.05)。治疗后研究组患者心输出量(CI)显著升高,血管外肺水指数(EVLWI)和PVPI显著降低,组间差异有统计学意义(P<0.05),组间胸腔内血容量(ITBVI)比较差异无统计学意义(P>0.05)。研究组中存活组CI显著高于死亡组,EVLWI和PVPI显著低于死亡组(P<0.05),两组ITBVI比较差异无统计学意义(P>0.05)。结论 PICCO可以反映慢性肺源性心脏病合并心源性休克患者血流动力学情况,对于指导患者治疗和预后判断具有重要的临床价值。 展开更多
关键词 肺心病 慢性病 休克 心原性 心排血量 预后
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脑血管病患者血清肿瘤坏死因子变化的研究
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作者 刘楠 郑安 +1 位作者 余启胜 黄华品 《免疫学杂志》 CAS CSCD 北大核心 1998年第3期182-183,共2页
观察111例脑血管病患者血清TNF水平的变化。结果表明:脑血管病患者血清TNF水平较正常对照组显著升高(P<0.001),且急性期患者血清TNF水平亦较恢复期患者显著升高(P<0.001),表明测定脑血管病患者血清T... 观察111例脑血管病患者血清TNF水平的变化。结果表明:脑血管病患者血清TNF水平较正常对照组显著升高(P<0.001),且急性期患者血清TNF水平亦较恢复期患者显著升高(P<0.001),表明测定脑血管病患者血清TNF有助于临床上观察病情发展、治疗效果及对预后的判断。 展开更多
关键词 肿瘤坏死因子 脑血管病 血清
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1988~1993年厦门口岸体检人群动态分析
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作者 骆惠兰 王榕榕 +1 位作者 黄耀福 夏贤昌 《中国国境卫生检疫杂志》 CAS 1994年第6期323-325,384,共3页
本文对1988~1993年经厦门口岸办理入出境体检各组人群动态进行分析,对传染病监测工作的有关问题进行讨论,提出建议。
关键词 1988~1993年 厦门口岸 体检 动态 入出境人群 传染病 疾病监测
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中国高血压防治指南2010 被引量:1220
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作者 刘力生 《中国医学前沿杂志(电子版)》 2011年第5期42-93,共52页
序言 高血压是最常见的慢性病,也是心脑血管病最主要的危险因素,其脑卒中、心肌梗死、心力衰竭及慢性肾脏病等主要并发症,不仅致残、致死率高,而且严重消耗医疗和社会资源,给家庭和国家造成沉重负担。
关键词 HYPERTENSION Drug therapy disease management GUIDELINES
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Physical activity as a treatment of non-alcoholic fatty liver disease:A systematic review 被引量:322
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作者 Maureen Whitsett Lisa B VanWagner 《World Journal of Hepatology》 CAS 2015年第16期2041-2052,共12页
AIM: To review the effectiveness of exercise as a therapy for nonalcoholic fatty liver disease(NAFLD) and potential benefits in treating insulin resistance and atherosclerosis.METHODS: Medline(EBSCOhost) and Pub Med w... AIM: To review the effectiveness of exercise as a therapy for nonalcoholic fatty liver disease(NAFLD) and potential benefits in treating insulin resistance and atherosclerosis.METHODS: Medline(EBSCOhost) and Pub Med were searched for English-language randomized controlled trials and prospective cohort studies in human adults aged ≥ 18 which investigated the various effects of exercise alone, a combination of exercise and diet, or exercise and diet coupled with behavioral modification on NAFLD from 2010 to Feburary 2015.RESULTS: Eighteen of 2298 available studies were chosen for critical review, which included 6925 patients. Nine(50%) studies were randomized controlled trials. Five(27.8%) studies utilized biopsy to examine the effects of physical activity on hepatic histology. The most commonly employed imaging modality to determine change in hepatic steatosis was hydrogen-magnetic resonance spectroscopy. Only two studies examined the effects of low impact physical activity for patients with significant mobility limitations and one compared the efficacy of aerobic and resistance exercise. No studies examined the exact duration of exercise required for hepatic and metabolic improvement in NAFLD.CONCLUSION: While exercise improved hepatic steatosis and underlying metabolic abnormalities in NAFLD, more studies are needed to define the most beneficial form and duration of exercise treatment. 展开更多
关键词 NONALCOHOLIC FATTY LIVER disease Nonalcoholicsteatohepatitis FATTY LIVER EXERCISE OBESITY
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自由基与疾病研究进展 被引量:157
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作者 李勇 孔令青 +1 位作者 高洪 严玉霖 《动物医学进展》 CSCD 2008年第4期85-88,共4页
随着基础医学和生命科学的不断发展,人们对自由基的研究越来越多,其中就有大量关于自由基与疾病的研究。自由基作为机体的正常代谢产物,在平衡状态下,其在抗菌、消炎和抑制肿瘤等方面具有重要作用和意义;一旦平衡被打破,如机体受到疾病... 随着基础医学和生命科学的不断发展,人们对自由基的研究越来越多,其中就有大量关于自由基与疾病的研究。自由基作为机体的正常代谢产物,在平衡状态下,其在抗菌、消炎和抑制肿瘤等方面具有重要作用和意义;一旦平衡被打破,如机体受到疾病或某些外源性药物和毒物的侵害,自由基便会产生强大的伤害作用,造成生物膜的脂质过氧化损伤,引起酶、氨基酸、蛋白质的氧化破坏,对内脏器官、免疫系统的形态功能产生影响,从而引起机体疾病,甚至死亡。目前,研究发现很多疾病的发生发展都与自由基有关。文章就自由基的产生、种类、与疾病的关系及清除进行了综述。 展开更多
关键词 自由基 疾病 应用
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A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version) 被引量:158
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作者 Ying-Hui Jin Lin Cai +44 位作者 Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 《Military Medical Research》 SCIE CAS CSCD 2020年第1期1-22,共22页
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a n... In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. 展开更多
关键词 2019 novel coronavirus 2019-nCoV Respiratory disease PNEUMONIA Infectious diseases Rapid advice guideline Clinical practice guideline Evidence-based medicine
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肠道菌群与疾病关系的研究进展 被引量:151
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作者 郭慧玲 邵玉宇 +1 位作者 孟和毕力格 张和平 《微生物学通报》 CAS CSCD 北大核心 2015年第2期400-410,共11页
人类肠道是一个多元化和充满活力的微生态系统,它的结构和功能成为目前生命科学和医学的研究热点。人类肠道拥有100万亿近1 000-1 150种细菌,在这个空间中它们与人类相互作用,对人类健康产生了巨大影响,其中有积极的作用,同时又伴随着... 人类肠道是一个多元化和充满活力的微生态系统,它的结构和功能成为目前生命科学和医学的研究热点。人类肠道拥有100万亿近1 000-1 150种细菌,在这个空间中它们与人类相互作用,对人类健康产生了巨大影响,其中有积极的作用,同时又伴随着潜在的威胁。本文详细论述了国内外关于肠道菌群与疾病关系的研究现状,益生菌对肠道菌群和健康的影响,以及研究肠道菌群的最新方法,为我国开展肠道微生物的研究提供部分参考,同时让人们更加了解肠道微生物对人类健康的影响。 展开更多
关键词 肠道微生物 疾病 研究方法
全文增补中
不完全川崎病的诊治现状 被引量:149
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作者 张清友 杜军保 《中华儿科杂志》 CAS CSCD 北大核心 2006年第5期339-341,共3页
关键词 川崎病诊断 disease 诊治 获得性心脏病 国内外 病因不明 世界各地 研究发现 不典型 KD
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The origin, transmission and clinical therapies on coronavirus disease 2019(COVID-19) outbreak——an update on the status 被引量:145
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作者 Yan-Rong Guo Qing-Dong Cao +6 位作者 Zhong-Si Hong Yuan-Yang Tan Shou-Deng Chen Hong-Jun Jin Kai-Sen Tan De-Yun Wang Yan Yan 《Military Medical Research》 SCIE CAS CSCD 2020年第1期93-103,共11页
An acute respiratory disease,caused by a novel coronavirus(SARS-CoV-2,previously known as 2019-nCoV),the coronavirus disease 2019(COVID-19)has spread throughout China and received worldwide attention.On 30 January 202... An acute respiratory disease,caused by a novel coronavirus(SARS-CoV-2,previously known as 2019-nCoV),the coronavirus disease 2019(COVID-19)has spread throughout China and received worldwide attention.On 30 January 2020,World Health Organization(WHO)officially declared the COVID-19 epidemic as a public health emergency of international concern.The emergence of SARS-CoV-2,since the severe acute respiratory syndrome coronavirus(SARSCoV)in 2002 and Middle East respiratory syndrome coronavirus(MERS-CoV)in 2012,marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century.As of 1 March 2020,a total of 87,137 confirmed cases globally,79,968 confirmed in China and 7169 outside of China,with 2977 deaths(3.4%)had been reported by WHO.Meanwhile,several independent research groups have identified that SARS-CoV-2 belongs toβ-coronavirus,with highly identical genome to bat coronavirus,pointing to bat as the natural host.The novel coronavirus uses the same receptor,angiotensin-converting enzyme 2(ACE2)as that for SARS-CoV,and mainly spreads through the respiratory tract.Importantly,increasingly evidence showed sustained human-tohuman transmission,along with many exported cases across the globe.The clinical symptoms of COVID-19 patients include fever,cough,fatigue and a small population of patients appeared gastrointestinal infection symptoms.The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes,which may be associated with acute respiratory distress syndrome(ARDS)and cytokine storm.Currently,there are few specific antiviral strategies,but several potent candidates of antivirals and repurposed drugs are under urgent investigation.In this review,we summarized the latest research progress of the epidemiology,pathogenesis,and clinical characteristics of COVID-19,and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. 展开更多
关键词 Clinical characteristics Coronavirus disease 2019(COVID-19) ORIGIN SARS-CoV-2 Therapy TRANSMISSION
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糖尿病及其并发症的临床研究 被引量:103
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作者 吕仁和 赵进喜 王世东 《新中医》 CAS 北大核心 2001年第3期3-5,共3页
糖尿病及其并发症是现代难治病之一。本文提出了糖尿病及其并发症分期辨证思路和糖尿病并发症发病“微型瘕形成”学说,并针对病和症状,总结出“六对论治”经验。
关键词 糖尿病 Zhen瘕 分期辨证 辨病 并发症 中医药疗法 临床研究
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基于卷积神经网络与迁移学习的油茶病害图像识别 被引量:138
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作者 龙满生 欧阳春娟 +1 位作者 刘欢 付青 《农业工程学报》 EI CAS CSCD 北大核心 2018年第18期194-201,共8页
传统的植物病害图像识别准确率严重依赖于耗时费力的人工特征设计。该文利用深度卷积神经网络强大的特征学习和特征表达能力来自动学习油茶病害特征,并借助迁移学习方法将Alex Net模型在Image Net图像数据集上学习得到的知识迁移到油茶... 传统的植物病害图像识别准确率严重依赖于耗时费力的人工特征设计。该文利用深度卷积神经网络强大的特征学习和特征表达能力来自动学习油茶病害特征,并借助迁移学习方法将Alex Net模型在Image Net图像数据集上学习得到的知识迁移到油茶病害识别任务。对油茶叶片图像进行阈值分割、旋转对齐、尺度缩放等预处理后,按照病害特征由人工分为藻斑病、软腐病、煤污病、黄化病和健康叶5个类别。每个类别各选取750幅图像组成样本集,从样本集中随机选择80%的样本用作训练集,剩余20%用作测试集。利用随机裁剪、旋转变换和透视变换对训练集进行数据扩充,以模拟图像采集的不同视角和减少网络模型的过拟合。在Tensor Flow深度学习框架下,基于数据扩充前后的样本集,对Alex Net进行全新学习和迁移学习。试验结果表明,迁移学习能够明显提高模型的收敛速度和分类性能;数据扩充有助于增加数据的多样性,避免出现过拟合现象;在迁移学习和数据扩充方式下的分类准确率高达96.53%,对藻斑病、软腐病、煤污病、黄化病、健康叶5类病害的F1得分分别达到94.28%、94.67%、97.31%、98.34%和98.03%。该方法具有较高的识别准确率,对平移、旋转具有较强的鲁棒性,可为植物叶片病害智能诊断提供参考。 展开更多
关键词 病害 分类 作物 油茶病害 图像识别 深度学习 迁移学习
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TGF-β and BMP signaling in osteoblast,skeletal development,and bone formation,homeostasis and disease 被引量:138
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作者 Mengrui Wu Guiqian Chen Yi-Ping Li 《Bone Research》 SCIE CAS CSCD 2016年第1期10-30,共21页
INTRODUCTIONThe transforming growth factor-β (TGF-β) superfamily com- prises TGF-βs, Activin, bone morphogenetic proteins (BMPs) and other related proteins. TGF-β superfamily members act through a heteromeric ... INTRODUCTIONThe transforming growth factor-β (TGF-β) superfamily com- prises TGF-βs, Activin, bone morphogenetic proteins (BMPs) and other related proteins. TGF-β superfamily members act through a heteromeric receptor complex,, comprised of type I and type II receptors at the cell surface that transduce intracellular signals via Smad complex or mitogen-activated protein kinase (MAPK) cascade. 展开更多
关键词 TGF BMP and BMP signaling in osteoblast skeletal development and bone formation homeostasis and disease BONE
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养殖刺参腐皮综合征病原菌的分离与鉴定 被引量:118
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作者 张春云 王印庚 荣小军 《水产学报》 CAS CSCD 北大核心 2006年第1期118-123,共6页
2003年春季,山东省青岛地区刺参养殖场暴发了较为严重的传染性疾病-“腐皮综合征”,该病引起的死亡造成约30%的损失。养殖刺参的发病症状表现为:厌食、摇头、肿嘴、排脏、身体萎缩、口部溃烂乃至体表大面积溃疡。从患病个体溃疡部位分... 2003年春季,山东省青岛地区刺参养殖场暴发了较为严重的传染性疾病-“腐皮综合征”,该病引起的死亡造成约30%的损失。养殖刺参的发病症状表现为:厌食、摇头、肿嘴、排脏、身体萎缩、口部溃烂乃至体表大面积溃疡。从患病个体溃疡部位分离得到一种优势细菌KL1,KL1经人工回接感染实验证明对健康刺参具有较强的致病性,且感染病参的症状与自然发病海参的症状相同。通过形态学、生理生化和16SrDNA分子生物学方法对该菌进行的分类鉴定表明,导致养成刺参“腐皮综合征”的致病菌是灿烂弧菌(Vibriosplendidus)。本文首次揭示了该地区“腐皮综合征”导致养成刺参大规模死亡的致病原因,对刺参病害防治和健康养殖具有重要的指导意义。 展开更多
关键词 刺参 海水养殖 疾病 细菌 腐皮综合征 16S RDNA
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Microproteinuria in patients with inflammatory bowel disease:Is it associated with the disease activity or the treatment with 5-aminosalicylic acid? 被引量:130
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作者 Androniki C Poulou Konstantinos E Goumas +5 位作者 Dimitrios C Dandakis Ioannis Tyrmpas Maria Panagiotaki Androniki Georgouli Dimitrios C Soutos Athanasios Archimandritis 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第5期739-746,共8页
AIM: To investigate whether microproteinuria in patients with inflammatory bowel disease (IBD) is associated with the disease activity or the treatment with 5-aminosalicylic acid (5-ASA). METHODS: We prospective... AIM: To investigate whether microproteinuria in patients with inflammatory bowel disease (IBD) is associated with the disease activity or the treatment with 5-aminosalicylic acid (5-ASA). METHODS: We prospectively studied microproteinuria in 86 consecutive patients with IBD, 61 with ulcerative colitis (UC) and 25 with Crohn's disease (CD), before as well as 2 and 6 months after their inclusion in the study. Forty-six patients received 5-ASA for a period of 28.8 months (range 1-168 too). Microalbuminuria (mALB) and urine levels of the renal tubular proteins β2-microglobulin (β2mGLB) and β-N-acetyI-D-glucosamidase (β-NAG) as well as the creatinine clearance were determined in a 12-h overnight urine collection. Tumor necrosis factor-α (TNF-α) serum levels were also measured. RESULTS: A total of 277 measurements (194 in UC patients and 83 in CD patients) were performed. The prevalence of abnormal microoproteinuria in UC and CD patients was 12.9% and 6.0% for mALB, 22.7% and 27.7% for B2mGLB, and 11.3% and 8.4% for β-NAG, respectively, mALB was not associated with IBD activity. β2mGLB and B-NAG urine levels were correlated to UC activity (UCAI: P〈0.01; UCEI: P〈0.005). mALB in UC patients and β-NAG urine levels in CD patients were related to TNF-α serum levels. An association was noticed between microproteinuria and smoking habit. Treatment with 5-ASA was not correlated to the severity of microproteinuria or to the changes of creatinine clearance.CONCLUSION: Microproteinuria is mainly associated with UC and its activity but not affected by 5-ASA. 展开更多
关键词 Inflammatory bowel disease Microproteinuria 5-aminosalicylic acid
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三七总皂苷药理作用研究进展 被引量:121
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作者 张剑峰 张丹参 《医学综述》 2007年第6期472-474,共3页
三七总皂苷是中药三七的主要成分,具有扩张血管、降低心肌耗氧量、抑制血小板凝集、延长凝血时间、降血脂、清除自由基、抗炎、抗氧化等药理作用。目前主要应用集中在心脑血管系统疾病和中枢神经系统疾病。近年来随着对其研究的不断深入... 三七总皂苷是中药三七的主要成分,具有扩张血管、降低心肌耗氧量、抑制血小板凝集、延长凝血时间、降血脂、清除自由基、抗炎、抗氧化等药理作用。目前主要应用集中在心脑血管系统疾病和中枢神经系统疾病。近年来随着对其研究的不断深入,又发现了许多新的药理作用和临床用途。 展开更多
关键词 三七总皂苷 心脑血管疾病 中枢神经系统疾病 抗纤维化 抗炎
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Prevalence of fatty liver disease and the economy in China: A systematic review 被引量:122
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作者 Jin-Zhou Zhu Qin-Yi Zhou +4 位作者 Yu-Ming Wang Yi-Ning Dai Jiang Zhu Chao-Hui Yu You-Ming Li 《World Journal of Gastroenterology》 SCIE CAS 2015年第18期5695-5706,共12页
AIM: To investigate the relationship between the economy and the adult prevalence of fatty liver disease(FLD) in China's Mainland. METHODS: Literature searches on the Pub Med and Chinese National Knowledge Infrast... AIM: To investigate the relationship between the economy and the adult prevalence of fatty liver disease(FLD) in China's Mainland. METHODS: Literature searches on the Pub Med and Chinese National Knowledge Infrastructure databases were performed to identify eligible studies published before July 2014. Records were limited to crosssectional surveys or baseline surveys of longitudinal studies that reported the adult prevalence of FLD and recruited subjects from the general population or community. The gross domestic product(GDP) per capita was chosen to assess the economic status. Multiple linear regression and Loess regression were chosen to fit the data and calculate the 95%CIs. Fitting and overfitting of the models were considered in choosing the appropriate models. RESULTS: There were 27 population-based surveys from 26 articles included in this study. The pooled mean prevalence of FLD in China was 16.73%(95%CI: 13.92%-19.53%). The prevalence of FLD was correlated with the GDP per capita and survey years in the country(adjusted R2 = 0.8736, P GDP per capita = 0.00426, P years = 0.0000394), as well as in coastal areas(R2 = 0.9196, P GDP per capita = 0.00241, P years = 0.00281). Furthermore, males [19.28%(95%CI: 15.68%-22.88%)] presented a higher prevalence than females [14.1%(95%CI: 11.42%-16.61%), P = 0.0071], especially in coastal areas [21.82(95%CI: 17.94%-25.71%) vs 17.01%(95%CI: 14.30%-19.89%), P = 0.0157]. Finally, the prevalence was predicted to reach 20.21% in 2020, increasing at a rate of 0.594% per year. CONCLUSION: This study reveals a correlation between the economy and the prevalence of FLD in China's Mainland. 展开更多
关键词 FATTY liver disease EPIDEMIOLOGY GROSS domestic product per capita PREVALENCE ECONOMY
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