AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochr...AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts.展开更多
Objective:Inflammatory bowel diseases (IBDs) are idiopathic,chronic,and inflammatory intestinal disorders.The two main types,ulcerative colitis (UC) and Crohn's disease (CD),sometimes mimic each other and are not ...Objective:Inflammatory bowel diseases (IBDs) are idiopathic,chronic,and inflammatory intestinal disorders.The two main types,ulcerative colitis (UC) and Crohn's disease (CD),sometimes mimic each other and are not readily distinguishable.The purpose of this study was to present a series of hospitalized cases,which could not initially be classified as a subtype of IBD,and to try to note roles of the terms indeterminate colitis (IC) and inflammatory bowel disease unclassified (IBDU) when such a dilemma arises.Methods:Medical records of 477 patients hospitalized due to IBD,during the period of January 2002 to April 2009,were retrospectively studied in the present paper.All available previous biopsies from endoscopies of these patients were reanalyzed.Results:Twenty-seven of 477 IBD patients (5.7%) had been initially diagnosed as having IBDU.Of them,23 received colonoscopy and histological examinations in our hospital.A total of 90% (9/10) and 66.7% (4/6) of patients,respectively,had a positive finding via wireless capsule endoscopy (CE) and double-balloon enteroscopy (DBE).The barium-swallow or small bowel follow-through (SBFT) was performed on 11 patients.Positive changes were observed under computer tomographic (CT) scanning in 89.5% (17/19) of patients.Reasonable treatment strategies were employed for all patients.Conclusions:Our data indicate that IBDU accounts for 5.7% of initial diagnoses of IBD.The definition of IBDU is valuable in clinical practice.For those who had no clear clinical,endoscopic,histological,or other features affording a diagnosis of either UC or CD,IBDU could be used parenthetically.展开更多
基金Supported by the“On Our Own Feet Movement-P?áteléstonozky”-Endowment Programand Research Project Progress Q-39
文摘AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts.
文摘Objective:Inflammatory bowel diseases (IBDs) are idiopathic,chronic,and inflammatory intestinal disorders.The two main types,ulcerative colitis (UC) and Crohn's disease (CD),sometimes mimic each other and are not readily distinguishable.The purpose of this study was to present a series of hospitalized cases,which could not initially be classified as a subtype of IBD,and to try to note roles of the terms indeterminate colitis (IC) and inflammatory bowel disease unclassified (IBDU) when such a dilemma arises.Methods:Medical records of 477 patients hospitalized due to IBD,during the period of January 2002 to April 2009,were retrospectively studied in the present paper.All available previous biopsies from endoscopies of these patients were reanalyzed.Results:Twenty-seven of 477 IBD patients (5.7%) had been initially diagnosed as having IBDU.Of them,23 received colonoscopy and histological examinations in our hospital.A total of 90% (9/10) and 66.7% (4/6) of patients,respectively,had a positive finding via wireless capsule endoscopy (CE) and double-balloon enteroscopy (DBE).The barium-swallow or small bowel follow-through (SBFT) was performed on 11 patients.Positive changes were observed under computer tomographic (CT) scanning in 89.5% (17/19) of patients.Reasonable treatment strategies were employed for all patients.Conclusions:Our data indicate that IBDU accounts for 5.7% of initial diagnoses of IBD.The definition of IBDU is valuable in clinical practice.For those who had no clear clinical,endoscopic,histological,or other features affording a diagnosis of either UC or CD,IBDU could be used parenthetically.
