[目的/意义]回顾和梳理图书馆资源发现系统的发展历程及研究进展,促进资源发现系统与图书馆业务发展深度融合与创新。[方法/过程]通过检索中国知网数据库、Web of Science、Emerald、Elsevier、Taylor&Francis SSH等数据库,运用内...[目的/意义]回顾和梳理图书馆资源发现系统的发展历程及研究进展,促进资源发现系统与图书馆业务发展深度融合与创新。[方法/过程]通过检索中国知网数据库、Web of Science、Emerald、Elsevier、Taylor&Francis SSH等数据库,运用内容分析和案例研究方法,总结图书馆资源发现系统理论研究、选型研究、部署实施、宣传推广、成效评价以及影响研究。[结果/结论]研究发现:资源发现系统在图书馆得到了快速应用,资源发现系统研究具有明显的周期性和阶段性,国内外资源发现系统发展演进具有差异性,研究内容以实践工作为主而理论深度不足,研究方法以案例研究、问卷调查方法为主,定量研究方法偏少。提出图书馆资源发现系统研究应与图书馆服务深度融合,拓展研究范围和加强研究深度,加强资源发现系统用户画像研究。展开更多
Traditional medicine (TM) plays an inevitable role in drug discovery and development. Most of the therapeutically useful molecules used in the present day are inspired from TM. Herbal drugs are the oldest forms of med...Traditional medicine (TM) plays an inevitable role in drug discovery and development. Most of the therapeutically useful molecules used in the present day are inspired from TM. Herbal drugs are the oldest forms of medicines used for the treatment of various ailments and the TM of every country has a long history of their usage. To develop more data on their quality, safety, and efficacy, so also to improve the consumer’s need of modern days several thrust areas of research are to be focused on the development of TM. Based on the above concept, a paradigm shift is required for the revitalization of TM. These facts along with the modern scientific approaches, molecular tools, and strategies make it necessary for TM to be revitalized. Confluencing several strategies with the technological and scientific developments including pharmacogenomics, nutrigenomics, system biology, and related approaches, the scientific potential of TM can be explored further with international coordination and collaborations.展开更多
Drug discovery and development has become longer and costlier process.The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards“me too”drugs and improved generics(505(b)...Drug discovery and development has become longer and costlier process.The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards“me too”drugs and improved generics(505(b)(2))fillings.The discontinuance of molecules at late stage clinical trials is common these years.The molecules are withdrawn at various stages of discovery and development process for reasons such as poor ADME properties,lack of efficacy and safety reasons.Hence this review focuses on possible applications of formulation and drug delivery to salvage molecules and improve the drugability.The formulation and drug delivery technologies are suitable for addressing various issues contributing to attrition are discussed in detail.展开更多
Serving as a way to understand the material composition,structure,and dynamic process of the Earth's interior,deep earth exploration is driven by not only mankind's pursuit of natural mysteries but also mankin...Serving as a way to understand the material composition,structure,and dynamic process of the Earth's interior,deep earth exploration is driven by not only mankind's pursuit of natural mysteries but also mankind's basic need to obtain resources and guarantee economic and social development.The first phase of deep earth exploration of China(SinoProbe)was carried out from 2008 to 2016 and tremendous results were achieved.In 2016,the China Geological Survey launched a Deep Geological Survey Project(also referred to as the Project)to continuously explore the deep Earth.Focusing on the national energy resources strategy,the Belt and Road Initiative,and major basic issues of the geological survey,the Project was carried out in Songliao Basin(an important energy base in China)and major geological boundaries and tectonic units including Qilian Mountains-Tianshan Mountains and Qinzhou-Hangzhou juncture belt.The purpose of it is to reveal the process,structure,and forming patterns of the deep ore deposits and petroleum reservoirs,clarify the evolutionary pattern and controlling factors of Mesozoic environmental climate,and discover deep fine structures of key orogens,basins,and mountains by comprehensive geophysical exploration and scientific drilling.Great achievements have been obtained after more than three years of efforts,including a cumulative 1552 km of deep seismic reflection profiles and magnetotelluric profiles,an ultra-deep continental scientific crilling well,a scientific drilling pilot hole,and a magnetotelluric array and a portable broadband seismic array,both of which cover South China.Moreover,significant progress has been made in ultra-deep drilling technology,deep oil and gas discovery in Songliao Basin,and basic geological issues of Qilian Orogen and Qinzhou-Hangzhou juncture belt in South China,greatly accelerating the deep earth exploration in China and further consolidating China's position as a power in deep earth exploration.展开更多
One of the most important breakthroughs in the history of genetics was the discovery that mutations can be artif icially induced in organisms (van Harten, 1998). Artif icially induced mutations, by physical and chemic...One of the most important breakthroughs in the history of genetics was the discovery that mutations can be artif icially induced in organisms (van Harten, 1998). Artif icially induced mutations, by physical and chemical muta-展开更多
文摘[目的/意义]回顾和梳理图书馆资源发现系统的发展历程及研究进展,促进资源发现系统与图书馆业务发展深度融合与创新。[方法/过程]通过检索中国知网数据库、Web of Science、Emerald、Elsevier、Taylor&Francis SSH等数据库,运用内容分析和案例研究方法,总结图书馆资源发现系统理论研究、选型研究、部署实施、宣传推广、成效评价以及影响研究。[结果/结论]研究发现:资源发现系统在图书馆得到了快速应用,资源发现系统研究具有明显的周期性和阶段性,国内外资源发现系统发展演进具有差异性,研究内容以实践工作为主而理论深度不足,研究方法以案例研究、问卷调查方法为主,定量研究方法偏少。提出图书馆资源发现系统研究应与图书馆服务深度融合,拓展研究范围和加强研究深度,加强资源发现系统用户画像研究。
基金the All India Council of Technical Education (AICTE), New Delhi for providing financial support through MODROB (F.No-8024/RID/ BOR/MOD-74/2008-09)RPS project grants (F.No-8023/BOR/RID/RPS-204/2008-09)
文摘Traditional medicine (TM) plays an inevitable role in drug discovery and development. Most of the therapeutically useful molecules used in the present day are inspired from TM. Herbal drugs are the oldest forms of medicines used for the treatment of various ailments and the TM of every country has a long history of their usage. To develop more data on their quality, safety, and efficacy, so also to improve the consumer’s need of modern days several thrust areas of research are to be focused on the development of TM. Based on the above concept, a paradigm shift is required for the revitalization of TM. These facts along with the modern scientific approaches, molecular tools, and strategies make it necessary for TM to be revitalized. Confluencing several strategies with the technological and scientific developments including pharmacogenomics, nutrigenomics, system biology, and related approaches, the scientific potential of TM can be explored further with international coordination and collaborations.
文摘Drug discovery and development has become longer and costlier process.The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards“me too”drugs and improved generics(505(b)(2))fillings.The discontinuance of molecules at late stage clinical trials is common these years.The molecules are withdrawn at various stages of discovery and development process for reasons such as poor ADME properties,lack of efficacy and safety reasons.Hence this review focuses on possible applications of formulation and drug delivery to salvage molecules and improve the drugability.The formulation and drug delivery technologies are suitable for addressing various issues contributing to attrition are discussed in detail.
基金This work was co-supported by the China Geological Survey project(DD20190012,DD20190011,DD20190010,DD20160207,D20160209,DD2016008,DD20160082 and DD20189702).
文摘Serving as a way to understand the material composition,structure,and dynamic process of the Earth's interior,deep earth exploration is driven by not only mankind's pursuit of natural mysteries but also mankind's basic need to obtain resources and guarantee economic and social development.The first phase of deep earth exploration of China(SinoProbe)was carried out from 2008 to 2016 and tremendous results were achieved.In 2016,the China Geological Survey launched a Deep Geological Survey Project(also referred to as the Project)to continuously explore the deep Earth.Focusing on the national energy resources strategy,the Belt and Road Initiative,and major basic issues of the geological survey,the Project was carried out in Songliao Basin(an important energy base in China)and major geological boundaries and tectonic units including Qilian Mountains-Tianshan Mountains and Qinzhou-Hangzhou juncture belt.The purpose of it is to reveal the process,structure,and forming patterns of the deep ore deposits and petroleum reservoirs,clarify the evolutionary pattern and controlling factors of Mesozoic environmental climate,and discover deep fine structures of key orogens,basins,and mountains by comprehensive geophysical exploration and scientific drilling.Great achievements have been obtained after more than three years of efforts,including a cumulative 1552 km of deep seismic reflection profiles and magnetotelluric profiles,an ultra-deep continental scientific crilling well,a scientific drilling pilot hole,and a magnetotelluric array and a portable broadband seismic array,both of which cover South China.Moreover,significant progress has been made in ultra-deep drilling technology,deep oil and gas discovery in Songliao Basin,and basic geological issues of Qilian Orogen and Qinzhou-Hangzhou juncture belt in South China,greatly accelerating the deep earth exploration in China and further consolidating China's position as a power in deep earth exploration.
文摘One of the most important breakthroughs in the history of genetics was the discovery that mutations can be artif icially induced in organisms (van Harten, 1998). Artif icially induced mutations, by physical and chemical muta-
