2,4(5)-Dinitroimidazole(2,4(5)-DNI)is an important organic intermediate,and itself can also be used for energetic material.In this work,the solubility of 2,4(5)-DNI in(methanol+water,acetonitrile+water,acetone+water)b...2,4(5)-Dinitroimidazole(2,4(5)-DNI)is an important organic intermediate,and itself can also be used for energetic material.In this work,the solubility of 2,4(5)-DNI in(methanol+water,acetonitrile+water,acetone+water)binary solvents were measured by using a dynamic test method from 278.15 K to 323.15 K under 101.1 k Pa.The Jouyban–Acree model,van't Hoff–Jouyban–Acree model,Apelblat–Jouyb an–Acree model,Ma model,and Sun model were used to correlate the experimental data.The values of relative average deviation(RAD)and root-mean-square deviation(RMSD)were very small,indicating that the error between the experimental value and the correlated value was very small.The thermodynamic parameters such as dissolution enthalpy,dissolution entropy and Gibbs energy were calculated based on solubility data.High-purity of 2,4(5)-DNI was efficiently obtained by using cooling and dilution crystallization method.展开更多
A mathematical model for dilution crystallization of spectinomycin dihydrochloride pentahydrate was established on the basis of the population and mass balance. Three operating modes, i.e., constant mass rate addition...A mathematical model for dilution crystallization of spectinomycin dihydrochloride pentahydrate was established on the basis of the population and mass balance. Three operating modes, i.e., constant mass rate addition of diluent, constant mass fraction of diluent and constant size-independent growth rate, were investigated over a wide range of controlled parameters. The intrinsic characteristics of the crystallization process and the influence of operation parameters were analyzed in detail. Suitable strategy for better performance was suggested.展开更多
The separation of 1,3-propanediol from the glycerol-based fermentation broth of Klebsiella pneumoniae plays an important role during the microbial production of 1,3-propanediol.In this paper,the separation of 1,3-prop...The separation of 1,3-propanediol from the glycerol-based fermentation broth of Klebsiella pneumoniae plays an important role during the microbial production of 1,3-propanediol.In this paper,the separation of 1,3-propanediol from fermentative broth by a combination of ultrafiltration and alcohol dilution crystallization was investi-gated.The broth was first filtered by ultrafiltration,and 99%of cells,89.4%of proteins and 69%of nucleic acids were removed.The obtained broth was further condensed by vacuum distillation,and then alcohol was added.The macro-molecular impurities,such as nucleic acids,polysaccharides and proteins,were precipitated,and inorganic and organic salts were crystallized.The optimal volume ratio of alcohol added to the condensed fermentation broth was determined to be 2:1.As a result,proteins,nucleic acids and electric conduc-tivity decreased by 97.4%,89.7%and 95.8%,respectively,compared with the fermentative broth.The influences of pH and water content in condensed broth on alcohol precipi-tation and dilution crystallization were also investigated.The experimental results indicated that alcohol precipitation and dilution crystallization was feasible and effective for the separation of 1,3-propanediol from actual fermentation broth.展开更多
文摘2,4(5)-Dinitroimidazole(2,4(5)-DNI)is an important organic intermediate,and itself can also be used for energetic material.In this work,the solubility of 2,4(5)-DNI in(methanol+water,acetonitrile+water,acetone+water)binary solvents were measured by using a dynamic test method from 278.15 K to 323.15 K under 101.1 k Pa.The Jouyban–Acree model,van't Hoff–Jouyban–Acree model,Apelblat–Jouyb an–Acree model,Ma model,and Sun model were used to correlate the experimental data.The values of relative average deviation(RAD)and root-mean-square deviation(RMSD)were very small,indicating that the error between the experimental value and the correlated value was very small.The thermodynamic parameters such as dissolution enthalpy,dissolution entropy and Gibbs energy were calculated based on solubility data.High-purity of 2,4(5)-DNI was efficiently obtained by using cooling and dilution crystallization method.
文摘A mathematical model for dilution crystallization of spectinomycin dihydrochloride pentahydrate was established on the basis of the population and mass balance. Three operating modes, i.e., constant mass rate addition of diluent, constant mass fraction of diluent and constant size-independent growth rate, were investigated over a wide range of controlled parameters. The intrinsic characteristics of the crystallization process and the influence of operation parameters were analyzed in detail. Suitable strategy for better performance was suggested.
基金supported by the National Basic Research Program of China(“973”project,Grant No.2003CB716000)the Tenth Five-Years’Projects of China Science and Technology Ministry(Grant No.2004BA713B06-03)the National Natural Science Foundation of China(Grant No.20576018).
文摘The separation of 1,3-propanediol from the glycerol-based fermentation broth of Klebsiella pneumoniae plays an important role during the microbial production of 1,3-propanediol.In this paper,the separation of 1,3-propanediol from fermentative broth by a combination of ultrafiltration and alcohol dilution crystallization was investi-gated.The broth was first filtered by ultrafiltration,and 99%of cells,89.4%of proteins and 69%of nucleic acids were removed.The obtained broth was further condensed by vacuum distillation,and then alcohol was added.The macro-molecular impurities,such as nucleic acids,polysaccharides and proteins,were precipitated,and inorganic and organic salts were crystallized.The optimal volume ratio of alcohol added to the condensed fermentation broth was determined to be 2:1.As a result,proteins,nucleic acids and electric conduc-tivity decreased by 97.4%,89.7%and 95.8%,respectively,compared with the fermentative broth.The influences of pH and water content in condensed broth on alcohol precipi-tation and dilution crystallization were also investigated.The experimental results indicated that alcohol precipitation and dilution crystallization was feasible and effective for the separation of 1,3-propanediol from actual fermentation broth.
