Climate change and rapid urbanization pose significant challenges to the conservation and management of agricultural heritage systems,including decline in agricultural land,loss of labor,and ecosystem degradation.Alth...Climate change and rapid urbanization pose significant challenges to the conservation and management of agricultural heritage systems,including decline in agricultural land,loss of labor,and ecosystem degradation.Although existing studies have proposed general strategies with theoretical guidance and specific strategies for particular systems to promote the conservation of agricultural heritage systems,there remains a large knowledge gap in effective and differentiated management strategies at the regional level.This is especially so in China because of the clear regional differences in the natural and socioeconomic conditions of the widely distributed China Nationally Important Agricultural Heritage Systems(China-NIAHS).In this study,we integrated multi-source data and spatial analysis to reveal the distribution characteristics of existing China-NIAHS and proposed differentiated management strategies.Results show that there are four clustering distribution zones of China-NIAHS,i.e.,the northwest clustering zone west of the Heihe-Tengchong Line(ZoneⅠ),the clustering belt with‘Northeast-Hebei-Shandong'as core(ZoneⅡ),the Yangtze River Delta clustering zone(ZoneⅢ),and the Hunan-Chongqing-Yunnan-Guizhou clustering zone(ZoneⅣ).Different management strategies are proposed for the China-NIAHS in each clustering zone.Specifically,ZoneⅠshould focus on maintaining their ecological functions and services,while ZoneⅡshould aim for livelihood supply,sustainable resource use,and ecological protection.For ZoneⅢ,rapid urbanization could become a positive driving force for China-NIAHS conservation through sustainable tourism and reasonable urban zoning.ZoneⅣshould emphasize the mutual support between characteristic product development and the brand effect of the China-NIAHS.These findings will help establish regional and targeted management strategies for China-NIAHS and provide a reference for the conservation of agricultural heritage systems in other countries.展开更多
目的分析新生大鼠缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD)后7周大脑皮层与对照组脑皮层的基因表达差异,探讨其生物学意义。方法从基因表达数据库(Gene Expression Omnibus database,GEO)中获取新生Wista大鼠缺氧缺血性...目的分析新生大鼠缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD)后7周大脑皮层与对照组脑皮层的基因表达差异,探讨其生物学意义。方法从基因表达数据库(Gene Expression Omnibus database,GEO)中获取新生Wista大鼠缺氧缺血性脑损伤后7周大脑皮层基因表达芯片数据集GSE37777。该数据集共8个样本,4个样本为HIBD组,4个样本为对照组。采用R软件包对数据做预处理和差异性表达基因(differentiallyexpressed genes,DEGs)的筛选,应用Cytoscape插件ClueGO+Cluepedia构建DEGs功能分组通路网络。通过相互作用基因库检索工具(Search Tool for the Retrieval of Interacting Genes,STRING)数据库和Cytoscape软件进行DEGs的蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络分析。结果 HIBD组共发现973DEGs,其中599个基因表达上调,374个基因表达下调。DEGs功能分组通路网络分析显示Hedgehog信号通路是最显著的差异性表达基因通路。HIBD组中Hedgehog通路相关基因Shh及Dhh表达上调,Wnt通路相关基因Wnt1、Wnt2B及Wnt5表达上调。PPI网络分析显示Ccnd1、Shh、Ret及Gli3是主要的中心蛋白,Shh和Ret表达上调,Ccnd1和Gli3表达下调。结论生物信息学分析显示,新生大鼠HIBD后7周脑皮层可能存在Hedgehog和Wnt信号通路的激活,与细胞修复相关的蛋白Shh及Ret的表达上调。新生大鼠HIBD 7周后脑皮层可能存在持续修复过程。展开更多
基金Strategic Priority Research Program of the Chinese Academy of Sciences,No.XDA23100203。
文摘Climate change and rapid urbanization pose significant challenges to the conservation and management of agricultural heritage systems,including decline in agricultural land,loss of labor,and ecosystem degradation.Although existing studies have proposed general strategies with theoretical guidance and specific strategies for particular systems to promote the conservation of agricultural heritage systems,there remains a large knowledge gap in effective and differentiated management strategies at the regional level.This is especially so in China because of the clear regional differences in the natural and socioeconomic conditions of the widely distributed China Nationally Important Agricultural Heritage Systems(China-NIAHS).In this study,we integrated multi-source data and spatial analysis to reveal the distribution characteristics of existing China-NIAHS and proposed differentiated management strategies.Results show that there are four clustering distribution zones of China-NIAHS,i.e.,the northwest clustering zone west of the Heihe-Tengchong Line(ZoneⅠ),the clustering belt with‘Northeast-Hebei-Shandong'as core(ZoneⅡ),the Yangtze River Delta clustering zone(ZoneⅢ),and the Hunan-Chongqing-Yunnan-Guizhou clustering zone(ZoneⅣ).Different management strategies are proposed for the China-NIAHS in each clustering zone.Specifically,ZoneⅠshould focus on maintaining their ecological functions and services,while ZoneⅡshould aim for livelihood supply,sustainable resource use,and ecological protection.For ZoneⅢ,rapid urbanization could become a positive driving force for China-NIAHS conservation through sustainable tourism and reasonable urban zoning.ZoneⅣshould emphasize the mutual support between characteristic product development and the brand effect of the China-NIAHS.These findings will help establish regional and targeted management strategies for China-NIAHS and provide a reference for the conservation of agricultural heritage systems in other countries.
文摘目的分析新生大鼠缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD)后7周大脑皮层与对照组脑皮层的基因表达差异,探讨其生物学意义。方法从基因表达数据库(Gene Expression Omnibus database,GEO)中获取新生Wista大鼠缺氧缺血性脑损伤后7周大脑皮层基因表达芯片数据集GSE37777。该数据集共8个样本,4个样本为HIBD组,4个样本为对照组。采用R软件包对数据做预处理和差异性表达基因(differentiallyexpressed genes,DEGs)的筛选,应用Cytoscape插件ClueGO+Cluepedia构建DEGs功能分组通路网络。通过相互作用基因库检索工具(Search Tool for the Retrieval of Interacting Genes,STRING)数据库和Cytoscape软件进行DEGs的蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络分析。结果 HIBD组共发现973DEGs,其中599个基因表达上调,374个基因表达下调。DEGs功能分组通路网络分析显示Hedgehog信号通路是最显著的差异性表达基因通路。HIBD组中Hedgehog通路相关基因Shh及Dhh表达上调,Wnt通路相关基因Wnt1、Wnt2B及Wnt5表达上调。PPI网络分析显示Ccnd1、Shh、Ret及Gli3是主要的中心蛋白,Shh和Ret表达上调,Ccnd1和Gli3表达下调。结论生物信息学分析显示,新生大鼠HIBD后7周脑皮层可能存在Hedgehog和Wnt信号通路的激活,与细胞修复相关的蛋白Shh及Ret的表达上调。新生大鼠HIBD 7周后脑皮层可能存在持续修复过程。
