An efficient procedure for the synthesis ofβ-keto esters from the reaction of aldehydes and ethyl diazoacetate catalyzed by iodine at room temperature under solvent-free conditions has been described. The catalytic p...An efficient procedure for the synthesis ofβ-keto esters from the reaction of aldehydes and ethyl diazoacetate catalyzed by iodine at room temperature under solvent-free conditions has been described. The catalytic procedure has the advantages of easily available catalyst, mild reaction conditions, high yields, and easy work-up.展开更多
Dicyclohexylmethyl diazoacetate was synthesized in excellent yield from the corresponding glycinate. which was derived in high yield from dicyclohexylmethyl chloroacetate via azide substitutuion, and reduction.
A highly efficient asymmetric cyclopropanation of trisubstituted olefins with methyl diazoacetate has been developed in terms of an elaborate modified chiral bisoxazoline/copper complex as a catalyst. A broad scope of...A highly efficient asymmetric cyclopropanation of trisubstituted olefins with methyl diazoacetate has been developed in terms of an elaborate modified chiral bisoxazoline/copper complex as a catalyst. A broad scope of substrates is compatible with this catalyst system, including various trisubstituted olefins bearing different aryl-, fused aryl-and alkyl-substituents, providing an easy access to optically active 1,1-dimethyl cyclopropanes in good yields with excellent diastereo-and enantio-selectivity.展开更多
Several cyclopropanation catalysts for the synthesis of 3(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylates have been studied in this paper. Owing to electron deficiency of 1,1-dichloro-4-methyl-1,3-pentadiene, ...Several cyclopropanation catalysts for the synthesis of 3(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylates have been studied in this paper. Owing to electron deficiency of 1,1-dichloro-4-methyl-1,3-pentadiene, yield of this reaction is rather law compared with that of 2,5-dimethyl-2,4-pentadiene, Of all catalysts concerned. yield ranged from 25.1% to 47.2%.展开更多
Nine copper compounds are used for catalyzing the cyclopropanation of 1-hexene/TME with alkyl diazoacetate.Cu(Salad)2 shows the highest yield for the reaction of TME at high temperature such as 100℃.The reaction of c...Nine copper compounds are used for catalyzing the cyclopropanation of 1-hexene/TME with alkyl diazoacetate.Cu(Salad)2 shows the highest yield for the reaction of TME at high temperature such as 100℃.The reaction of crude RDA with TME in 73.7% yield under the optimal condition is obtained.展开更多
Metal clusters have been suggested as active catalysts in a variety of homogeneous catalytic reactions. In this paper the cyclopropanation of styrene with ethyl diazoacetate is catalyzed by metal cluster (μ 3 S)Fe 2C...Metal clusters have been suggested as active catalysts in a variety of homogeneous catalytic reactions. In this paper the cyclopropanation of styrene with ethyl diazoacetate is catalyzed by metal cluster (μ 3 S)Fe 2CoCu(PPh 3) 2 (CO) 8 for the first time. Expenimental results show that toluene as solvent, Styrene/EDA=4, EDA/Cat.=100, , 30 ℃ and 24 h are the best conditions. After reaction, the catalyst was isolated and characterized.展开更多
基金Supported by the Special Scientific Research Project of Shaanxi Education Commission(No.08JZ09) the Science Re-search Foundation of Baoji University of Arts and Sciences, China(No.ZK064)
文摘An efficient procedure for the synthesis ofβ-keto esters from the reaction of aldehydes and ethyl diazoacetate catalyzed by iodine at room temperature under solvent-free conditions has been described. The catalytic procedure has the advantages of easily available catalyst, mild reaction conditions, high yields, and easy work-up.
文摘Dicyclohexylmethyl diazoacetate was synthesized in excellent yield from the corresponding glycinate. which was derived in high yield from dicyclohexylmethyl chloroacetate via azide substitutuion, and reduction.
基金supported by the National Natural Science Foundation of China(21432011,21772224)Key Research Program of Frontier Sciences of Chinese Academy of Sciences(QYZDY-SSWSLH016)+2 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000)the Youth Innovation Promotion Association CAS(2017301)the National Basic Research Program of China(2015CB856600)
文摘A highly efficient asymmetric cyclopropanation of trisubstituted olefins with methyl diazoacetate has been developed in terms of an elaborate modified chiral bisoxazoline/copper complex as a catalyst. A broad scope of substrates is compatible with this catalyst system, including various trisubstituted olefins bearing different aryl-, fused aryl-and alkyl-substituents, providing an easy access to optically active 1,1-dimethyl cyclopropanes in good yields with excellent diastereo-and enantio-selectivity.
文摘Several cyclopropanation catalysts for the synthesis of 3(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylates have been studied in this paper. Owing to electron deficiency of 1,1-dichloro-4-methyl-1,3-pentadiene, yield of this reaction is rather law compared with that of 2,5-dimethyl-2,4-pentadiene, Of all catalysts concerned. yield ranged from 25.1% to 47.2%.
文摘Nine copper compounds are used for catalyzing the cyclopropanation of 1-hexene/TME with alkyl diazoacetate.Cu(Salad)2 shows the highest yield for the reaction of TME at high temperature such as 100℃.The reaction of crude RDA with TME in 73.7% yield under the optimal condition is obtained.
文摘Metal clusters have been suggested as active catalysts in a variety of homogeneous catalytic reactions. In this paper the cyclopropanation of styrene with ethyl diazoacetate is catalyzed by metal cluster (μ 3 S)Fe 2CoCu(PPh 3) 2 (CO) 8 for the first time. Expenimental results show that toluene as solvent, Styrene/EDA=4, EDA/Cat.=100, , 30 ℃ and 24 h are the best conditions. After reaction, the catalyst was isolated and characterized.
