目的探讨口服低氘水对^(131)I治疗甲状腺癌致辐射性胃肠炎的疗效。方法连续收集2022年5月—2023年2月于常熟市第二人民医院核医学科采用^(131)I治疗的甲状腺乳头状癌(下简称甲状腺癌)患者50例,将其分为对照组和实验组,每组25例。对照组...目的探讨口服低氘水对^(131)I治疗甲状腺癌致辐射性胃肠炎的疗效。方法连续收集2022年5月—2023年2月于常熟市第二人民医院核医学科采用^(131)I治疗的甲状腺乳头状癌(下简称甲状腺癌)患者50例,将其分为对照组和实验组,每组25例。对照组予以口服奥美拉唑肠溶胶囊,同时予口服纯净水660 mL tid,连续5 d;实验组在同对照组用药的基础上予口服低氘水660 mL tid,连续5 d。采用Fisher`s精确检验及Kaplan-Meier分析,观察比较2组患者服^(131)I后辐射性胃肠炎发生情况,及胃肠道临床症状的缓解情况。结果服^(131)I后第1天至第5天,实验组患者发生胃肠道炎症例数分别为2(8%),5(20%),2(8%),1(4%),0(0%);对照组为2(8%),8(32%),4(16%),3(12%),1(4%)。2组间胃肠道炎发生率比较差异具有统计学意义(χ^(2)=4.064,P=0.044)。治疗5 d后,实验组患者总有效率96%,高于对照组的76%,2组间差异有统计学意义(χ^(2)=9.105,P=0.025)。结论口服低氘水对^(131)I治疗甲状腺癌致辐射性胃肠道炎临床症状的缓解具有一定的疗效。建议临床进一步探讨应用。展开更多
The concentration of the heavy isotope of hydrogen, deuterium (D), is not routinely measured in (human) medical laboratory tests, even though an increasing number of papers prove the pivotal role of D in tumor growth,...The concentration of the heavy isotope of hydrogen, deuterium (D), is not routinely measured in (human) medical laboratory tests, even though an increasing number of papers prove the pivotal role of D in tumor growth, cell cycle regulation, cell metabolism, and aging. Data from a prospective phase 2 clinical study and numerous retrospective clinical studies proved the anticancer effect of deuterium depletion achieved by replacing the regular water intake with deuterium-depleted water (DDW). In previous studies, the changes in serum D concentration of DDW-consuming patients were followed using blood samples and mass spectrometry, which was invasive, costly, and time-consuming. As future clinical trials will also require a follow-up of internal D level and the patient’s compliance, a new sampling device and procedure was developed based on condensing the exhaled breath water vapor and measuring its D content using a liquid water isotope laser analyzer. Test results showed that the device provided accurate, reliable, and reproducible data. According to the data, the internal D level in a person consuming normal water was stable. In contrast, exclusive consumption of DDW for several days resulted in a gradual decrease of D concentration in exhaled breath condensate (EBC), which was proportional to the D concentration of DDW. These data confirm that orally applied DDW equilibrates with the person’s water pool quickly, leading to a reduced internal D level reflected in the D content of EBC.展开更多
文摘目的探讨口服低氘水对^(131)I治疗甲状腺癌致辐射性胃肠炎的疗效。方法连续收集2022年5月—2023年2月于常熟市第二人民医院核医学科采用^(131)I治疗的甲状腺乳头状癌(下简称甲状腺癌)患者50例,将其分为对照组和实验组,每组25例。对照组予以口服奥美拉唑肠溶胶囊,同时予口服纯净水660 mL tid,连续5 d;实验组在同对照组用药的基础上予口服低氘水660 mL tid,连续5 d。采用Fisher`s精确检验及Kaplan-Meier分析,观察比较2组患者服^(131)I后辐射性胃肠炎发生情况,及胃肠道临床症状的缓解情况。结果服^(131)I后第1天至第5天,实验组患者发生胃肠道炎症例数分别为2(8%),5(20%),2(8%),1(4%),0(0%);对照组为2(8%),8(32%),4(16%),3(12%),1(4%)。2组间胃肠道炎发生率比较差异具有统计学意义(χ^(2)=4.064,P=0.044)。治疗5 d后,实验组患者总有效率96%,高于对照组的76%,2组间差异有统计学意义(χ^(2)=9.105,P=0.025)。结论口服低氘水对^(131)I治疗甲状腺癌致辐射性胃肠道炎临床症状的缓解具有一定的疗效。建议临床进一步探讨应用。
文摘The concentration of the heavy isotope of hydrogen, deuterium (D), is not routinely measured in (human) medical laboratory tests, even though an increasing number of papers prove the pivotal role of D in tumor growth, cell cycle regulation, cell metabolism, and aging. Data from a prospective phase 2 clinical study and numerous retrospective clinical studies proved the anticancer effect of deuterium depletion achieved by replacing the regular water intake with deuterium-depleted water (DDW). In previous studies, the changes in serum D concentration of DDW-consuming patients were followed using blood samples and mass spectrometry, which was invasive, costly, and time-consuming. As future clinical trials will also require a follow-up of internal D level and the patient’s compliance, a new sampling device and procedure was developed based on condensing the exhaled breath water vapor and measuring its D content using a liquid water isotope laser analyzer. Test results showed that the device provided accurate, reliable, and reproducible data. According to the data, the internal D level in a person consuming normal water was stable. In contrast, exclusive consumption of DDW for several days resulted in a gradual decrease of D concentration in exhaled breath condensate (EBC), which was proportional to the D concentration of DDW. These data confirm that orally applied DDW equilibrates with the person’s water pool quickly, leading to a reduced internal D level reflected in the D content of EBC.
