The hybrid-HVDC topology,which consists of line-commutated-converter(LCC)and voltage source converter(VSC)and combines their advantages,has extensive application prospects.A hybrid-HVDC system,adopting VSC on rectifie...The hybrid-HVDC topology,which consists of line-commutated-converter(LCC)and voltage source converter(VSC)and combines their advantages,has extensive application prospects.A hybrid-HVDC system,adopting VSC on rectifier side and LCC on inverter side,is investigated,and its mathematic model is deduced.The commutation failure issue of the LCC converter in the hybrid-HVDC system is considered,and a novel coordinated control method is proposed to enhance the system commutation failure immunity.A voltage dependent voltage order limiter(VDVOL)is designed based on the constant DC voltage control on the rectifier side,and constant extinction angle backup control is introduced based on the constant DC current control with voltage dependent current order limiter(VDCOL)on the inverter side.The hybrid-HVDC system performances under normal operation state and fault state are simulated in the PSCAD/EMTDC.Then,system transient state performances with or without the proposed control methods under fault condition are further compared and analyzed.It is concluded that the proposed control method has the ability to effectively reduce the probability of commutation failure and improve the fault recovery performance of the hybrid-HVDC system.展开更多
The reliability assessment problem for products subject to degradation and random shocks is investigated. Two kinds of probabilistic models are constructed, in which the dependent competing failure process is consider...The reliability assessment problem for products subject to degradation and random shocks is investigated. Two kinds of probabilistic models are constructed, in which the dependent competing failure process is considered. First, based on the assumption of cumulative shock, the probabilistic models for hard failure and soft failure are built respectively. On this basis, the dependent competing failure model involving degradation and shock processes is established. Furthermore, the situation of the shifting-threshold is also considered, in which the hard failure threshold value decreases to a lower level after the arrival of a certain number of shocks. A case study of fatigue crack growth is given to illustrate the proposed models. Numerical results show that shock has a significant effect on the failure process; meanwhile, the effect will be magnified when the value of the hard threshold shifts to a lower level.展开更多
BACKGROUND Sodium-dependent glucose transporter 2 inhibitors(SGLT2i)have shown efficacy in reducing heart failure(HF)burden in a very heterogeneous groups of patients,raising doubts about some contemporary assumptions...BACKGROUND Sodium-dependent glucose transporter 2 inhibitors(SGLT2i)have shown efficacy in reducing heart failure(HF)burden in a very heterogeneous groups of patients,raising doubts about some contemporary assumptions of their mechanism of action.We previously published a prospective observational study that evaluated mechanisms of action of SGLT2i in patients with type 2 diabetes who were in HF stages A and B on dual hypoglycemic therapy.Two groups of patients were included in the study:the ones receiving SGLT2i as an add-on agent to metformin and the others on dipeptidyl peptidase-4 inhibitors as an add-on to metformin due to suboptimal glycemic control.AIM To evaluate the outcomes regarding natriuretic peptide,oxidative stress,inflammation,blood pressure,heart rate,cardiac function,and body weight.METHODS The study outcomes were examined by dividing each treatment arm into two subgroups according to baseline parameters of global longitudinal strain(GLS),N-terminal pro-brain natriuretic peptide,myeloperoxidase(MPO),high-sensitivity C-reactive protein(hsCRP),and systolic and diastolic blood pressure.To evaluate the possible predictors of observed changes in the SGLT2i arm during follow-up,a rise in stroke volume index,body mass index(BMI)decrease,and lack of heart rate increase,linear regression analysis was performed.RESULTS There was a greater reduction of MPO,hsCRP,GLS,and blood pressure in the groups with higher baseline values of mentioned parameters irrespective of the therapeutic arm after 6 months of follow-up.Significant independent predictors of heart rate decrease were a reduction in early mitral inflow velocity to early diastolic mitral annular velocity at the interventricular septal annulus ratio and BMI,while the predictor of stroke volume index increase was SGLT2i therapy itself.CONCLUSION SGLT2i affect body composition,reduce cardiac load,improve diastolic/systolic function,and attenuate the sympathetic response.Glycemic control contributes to the improvement of heart function,blood pressure cont展开更多
基金supported by the National High Technology Research and Development Program of China("863" Program)(Grant No.2013AA050105)the National Natural Science Foundation of China(Grant No.51177042)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.13QN03)2012 science and technology projects of State Grid Corporation of China(Grant No.XT71-12-015)
文摘The hybrid-HVDC topology,which consists of line-commutated-converter(LCC)and voltage source converter(VSC)and combines their advantages,has extensive application prospects.A hybrid-HVDC system,adopting VSC on rectifier side and LCC on inverter side,is investigated,and its mathematic model is deduced.The commutation failure issue of the LCC converter in the hybrid-HVDC system is considered,and a novel coordinated control method is proposed to enhance the system commutation failure immunity.A voltage dependent voltage order limiter(VDVOL)is designed based on the constant DC voltage control on the rectifier side,and constant extinction angle backup control is introduced based on the constant DC current control with voltage dependent current order limiter(VDCOL)on the inverter side.The hybrid-HVDC system performances under normal operation state and fault state are simulated in the PSCAD/EMTDC.Then,system transient state performances with or without the proposed control methods under fault condition are further compared and analyzed.It is concluded that the proposed control method has the ability to effectively reduce the probability of commutation failure and improve the fault recovery performance of the hybrid-HVDC system.
基金The National Natural Science Foundation of China(No.50405021)Graduate Training Innovative Projects Foundation of Jiangsu Province(No.CXLX12_0081)
文摘The reliability assessment problem for products subject to degradation and random shocks is investigated. Two kinds of probabilistic models are constructed, in which the dependent competing failure process is considered. First, based on the assumption of cumulative shock, the probabilistic models for hard failure and soft failure are built respectively. On this basis, the dependent competing failure model involving degradation and shock processes is established. Furthermore, the situation of the shifting-threshold is also considered, in which the hard failure threshold value decreases to a lower level after the arrival of a certain number of shocks. A case study of fatigue crack growth is given to illustrate the proposed models. Numerical results show that shock has a significant effect on the failure process; meanwhile, the effect will be magnified when the value of the hard threshold shifts to a lower level.
文摘BACKGROUND Sodium-dependent glucose transporter 2 inhibitors(SGLT2i)have shown efficacy in reducing heart failure(HF)burden in a very heterogeneous groups of patients,raising doubts about some contemporary assumptions of their mechanism of action.We previously published a prospective observational study that evaluated mechanisms of action of SGLT2i in patients with type 2 diabetes who were in HF stages A and B on dual hypoglycemic therapy.Two groups of patients were included in the study:the ones receiving SGLT2i as an add-on agent to metformin and the others on dipeptidyl peptidase-4 inhibitors as an add-on to metformin due to suboptimal glycemic control.AIM To evaluate the outcomes regarding natriuretic peptide,oxidative stress,inflammation,blood pressure,heart rate,cardiac function,and body weight.METHODS The study outcomes were examined by dividing each treatment arm into two subgroups according to baseline parameters of global longitudinal strain(GLS),N-terminal pro-brain natriuretic peptide,myeloperoxidase(MPO),high-sensitivity C-reactive protein(hsCRP),and systolic and diastolic blood pressure.To evaluate the possible predictors of observed changes in the SGLT2i arm during follow-up,a rise in stroke volume index,body mass index(BMI)decrease,and lack of heart rate increase,linear regression analysis was performed.RESULTS There was a greater reduction of MPO,hsCRP,GLS,and blood pressure in the groups with higher baseline values of mentioned parameters irrespective of the therapeutic arm after 6 months of follow-up.Significant independent predictors of heart rate decrease were a reduction in early mitral inflow velocity to early diastolic mitral annular velocity at the interventricular septal annulus ratio and BMI,while the predictor of stroke volume index increase was SGLT2i therapy itself.CONCLUSION SGLT2i affect body composition,reduce cardiac load,improve diastolic/systolic function,and attenuate the sympathetic response.Glycemic control contributes to the improvement of heart function,blood pressure cont
