Objective:To compare the eflect of zoledronic acid in treatment and prevention of osteoporosis with placebo.Methods:Random control trials regarding zoleilroiiic acid in treatment of osteoporosis were retrieved by sele...Objective:To compare the eflect of zoledronic acid in treatment and prevention of osteoporosis with placebo.Methods:Random control trials regarding zoleilroiiic acid in treatment of osteoporosis were retrieved by selecting Medline.EMbase and Pubmed databases till April 2012. The RevMan software was used for all of the statistical analysis.Results:A total of 9 trials were included in this meta-analysis.The pooled effect shewed that zoledronic acid could increase the bone mineral density by 2.98 times compared with placebo,and reduce the rate of fracture in patients by 32%.The results should the zoledronic acid intervention had significantly less serious adverse events than controls,and the odds ratio was 0.81(0.76-0.87).The longer term intervention, more than 12 months intervention,could gain a better prevention effect for osteoporosis(OR,95% CI for RMD was 3.35.2.77-3.92:for fracture was 0.67.0.54-0.82).Conclusions:This present study shows that zoledronic acid could be effective approach in the prevention of osteoporosis,and could increase the bone mineral density and reduce the risk ol facture.展开更多
Objective:To clarify the effect of soy isoflavones on prevention of osteoporosis,and the effective dosage of soy isoflavones and its duration.Methods:Random control trials that investigated the association of soy isof...Objective:To clarify the effect of soy isoflavones on prevention of osteoporosis,and the effective dosage of soy isoflavones and its duration.Methods:Random control trials that investigated the association of soy isoflavones and osteoporosis were included in the meta-analysis by researching MEDLINE,EMBASE and the Chinese Biomedical Database up to October 2011.The RevMan software was used for all of the statistical analysis.Results:The present meta-analysis found that soy isoflavones significantly increased the bone mineral density by 54%and decreased the bone resorption marker urinary deoxypyridinoline(DPD) by 23%compared to baseline in women. Using random effects model,the effect of isoflavones on bone mineral density(BMD) regarding menopausal status and isoflavone dose revealed higher weighted mean difference changes were found in postmenopausal women and isoflavone dose above 75 mg/d.Subgroup analysis of trials with menopausal status,supplement type,isoflavone dose and intervention duration that used soy isoflavone extracts resulted in significant diflerent overall effect of DPD using by random effects model.Sensitivity analysis indicated that the effect of soy isoflavones on BMD and DPD was robust.Conclusions:The present meta-analysis reveals that soy isoflavone supplements significandy increase bone mineral density and decrease the bone,resorption marker urinary DPD.It shows no significant effect on bone formation markers serum bone alkaline phosphatase. The significant effect of soy isoflavones on BMD and urinary DPD is relative to menopausal status, supplement type,isoflavone dose and intervention duration.展开更多
Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an...Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low-density lipoprotein (ox-LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox-LDL, the methods of measuring ox-LDL in the circulation, effect of medical therapy and life-style modification on ox-LDL level, and the association between circulating ox-LDL and atherosclerosis, including clinical ASCVD events and subclinical atherosclerosis, in observational studies.展开更多
目的:探讨饮酒对骨密度的影响。方法:应用计算机检索中国知网、维普网、万方数据库、中国生物医学文献数据库、Pubmed、Embase、Web of Science、Cochrane library建库至2019年4月30日收录的有关饮酒对骨密度影响的观察性研究文献。由2...目的:探讨饮酒对骨密度的影响。方法:应用计算机检索中国知网、维普网、万方数据库、中国生物医学文献数据库、Pubmed、Embase、Web of Science、Cochrane library建库至2019年4月30日收录的有关饮酒对骨密度影响的观察性研究文献。由2位研究者独立筛选文献、提取资料,依据Newcastle-Ottawa量表进行文献质量评价后,采用RevMan5.3软件进行Meta分析。结果:最初共检索到5811篇文献,其中中文文献2586篇、英文文献3225篇。经筛选后共有8篇文献纳入本次分析,中文文献和英文文献各4篇。纳入的8篇文献质量均较高,Newcastle-Ottawa量表评分均≥6分。Meta分析结果显示,饮酒组骨密度降低的风险高于非饮酒组[OR=2.58,95%CI(1.62,4.10)]。按样本来源进行亚组分析,国内人群和国外人群中饮酒组骨密度降低的风险均高于非饮酒组,其中国内人群中饮酒组骨密度降低的风险更高[OR=5.01,95%CI(2.04,12.33);OR=1.61,95%CI(1.19,2.16)]。按性别进行亚组分析,男性人群中饮酒组骨密度降低的风险高于非饮酒组[OR=3.02,95%CI(1.69,5.39)],女性人群中饮酒组与非饮酒组骨密度降低风险的差异无统计学意义[OR=1.37,95%CI(0.68,2.74)]。剔除样本量最大的1篇文献后,Meta分析结果与未剔除文献前相比没有改变。漏斗图显示左下角出现空缺。结论:饮酒会增加骨密度降低的风险;饮酒引起国内人群骨密度降低的风险高于国外人群,饮酒引起男性骨密度降低的风险高于女性。展开更多
Objective To systematically evaluate the effects of different forms of traditional Chinese health-preservation exercises on osteoporosis(OP)using network meta-analysis.Methods A systematic search on Excerpta Medica Da...Objective To systematically evaluate the effects of different forms of traditional Chinese health-preservation exercises on osteoporosis(OP)using network meta-analysis.Methods A systematic search on Excerpta Medica Database(EMBASE),Springer Link,Allied and Complementary Medicine Database(AMED),PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang)and Chongqing VIP Database(CQVIP)targeted the randomized controlled trials(RCTs)studying traditional Chinese exercises for OP published up to January 2020.Cochrane handbook was adopted to estimate the publication bias in the included studies,and statistical analysis was performed using Stata 14.0 and GeMTC 0.14.3 when data were extracted.Results Fifty RCTs were included in the network meta-analysis,comprising a total of 4505 OP patients.The network meta-analysis showed that in terms of visual analog scale(VAS)for pain,Tai Ji Quan(Tai Chi)was the most efficacious,followed by Yi Jin Jing(Sinew-transforming Qigong Exercises),Ba Duan Jin(Eight-sectioned Exercise),Wu Qin Xi(Five-animal Exercises),sports training,drug and blank control;in terms of bone mineral density(BMD)of femoral neck,Yi Jin Jing was the most efficacious,followed by Wu Qin Xi,Ba Duan Jin,Tai Ji Quan,sports training,blank control and drug;regarding the lumbar BMD,it was Yi Jin Jing,Tai Ji Quan,Ba Duan Jin,Wu Qin Xi,sports training,blank control and drug in the descending order of efficacy;in terms of serum alkaline phosphatase,it was Yi Jin Jing,Tai Ji Quan,sports training,Wu Qin Xi,Ba Duan Jin,drug and blank control in the descending order of efficacy.Conclusion The evidence to date suggests that the first choice for OP amongst the traditional Chinese exercises should be Yi Jin Jing,which can not only reduce the subjective pain,but also promote bone formation and increase BMD,though this conclusion requires more high-quality large-scale RCTs for further proof.展开更多
文摘Objective:To compare the eflect of zoledronic acid in treatment and prevention of osteoporosis with placebo.Methods:Random control trials regarding zoleilroiiic acid in treatment of osteoporosis were retrieved by selecting Medline.EMbase and Pubmed databases till April 2012. The RevMan software was used for all of the statistical analysis.Results:A total of 9 trials were included in this meta-analysis.The pooled effect shewed that zoledronic acid could increase the bone mineral density by 2.98 times compared with placebo,and reduce the rate of fracture in patients by 32%.The results should the zoledronic acid intervention had significantly less serious adverse events than controls,and the odds ratio was 0.81(0.76-0.87).The longer term intervention, more than 12 months intervention,could gain a better prevention effect for osteoporosis(OR,95% CI for RMD was 3.35.2.77-3.92:for fracture was 0.67.0.54-0.82).Conclusions:This present study shows that zoledronic acid could be effective approach in the prevention of osteoporosis,and could increase the bone mineral density and reduce the risk ol facture.
文摘Objective:To clarify the effect of soy isoflavones on prevention of osteoporosis,and the effective dosage of soy isoflavones and its duration.Methods:Random control trials that investigated the association of soy isoflavones and osteoporosis were included in the meta-analysis by researching MEDLINE,EMBASE and the Chinese Biomedical Database up to October 2011.The RevMan software was used for all of the statistical analysis.Results:The present meta-analysis found that soy isoflavones significantly increased the bone mineral density by 54%and decreased the bone resorption marker urinary deoxypyridinoline(DPD) by 23%compared to baseline in women. Using random effects model,the effect of isoflavones on bone mineral density(BMD) regarding menopausal status and isoflavone dose revealed higher weighted mean difference changes were found in postmenopausal women and isoflavone dose above 75 mg/d.Subgroup analysis of trials with menopausal status,supplement type,isoflavone dose and intervention duration that used soy isoflavone extracts resulted in significant diflerent overall effect of DPD using by random effects model.Sensitivity analysis indicated that the effect of soy isoflavones on BMD and DPD was robust.Conclusions:The present meta-analysis reveals that soy isoflavone supplements significandy increase bone mineral density and decrease the bone,resorption marker urinary DPD.It shows no significant effect on bone formation markers serum bone alkaline phosphatase. The significant effect of soy isoflavones on BMD and urinary DPD is relative to menopausal status, supplement type,isoflavone dose and intervention duration.
基金the National Natural Science Foundation of China，the Na-tional Science&Technology Pillar Program during the 13th Five-Year Plan Period of China
文摘Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low-density lipoprotein (ox-LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox-LDL, the methods of measuring ox-LDL in the circulation, effect of medical therapy and life-style modification on ox-LDL level, and the association between circulating ox-LDL and atherosclerosis, including clinical ASCVD events and subclinical atherosclerosis, in observational studies.
文摘目的:探讨饮酒对骨密度的影响。方法:应用计算机检索中国知网、维普网、万方数据库、中国生物医学文献数据库、Pubmed、Embase、Web of Science、Cochrane library建库至2019年4月30日收录的有关饮酒对骨密度影响的观察性研究文献。由2位研究者独立筛选文献、提取资料,依据Newcastle-Ottawa量表进行文献质量评价后,采用RevMan5.3软件进行Meta分析。结果:最初共检索到5811篇文献,其中中文文献2586篇、英文文献3225篇。经筛选后共有8篇文献纳入本次分析,中文文献和英文文献各4篇。纳入的8篇文献质量均较高,Newcastle-Ottawa量表评分均≥6分。Meta分析结果显示,饮酒组骨密度降低的风险高于非饮酒组[OR=2.58,95%CI(1.62,4.10)]。按样本来源进行亚组分析,国内人群和国外人群中饮酒组骨密度降低的风险均高于非饮酒组,其中国内人群中饮酒组骨密度降低的风险更高[OR=5.01,95%CI(2.04,12.33);OR=1.61,95%CI(1.19,2.16)]。按性别进行亚组分析,男性人群中饮酒组骨密度降低的风险高于非饮酒组[OR=3.02,95%CI(1.69,5.39)],女性人群中饮酒组与非饮酒组骨密度降低风险的差异无统计学意义[OR=1.37,95%CI(0.68,2.74)]。剔除样本量最大的1篇文献后,Meta分析结果与未剔除文献前相比没有改变。漏斗图显示左下角出现空缺。结论:饮酒会增加骨密度降低的风险;饮酒引起国内人群骨密度降低的风险高于国外人群,饮酒引起男性骨密度降低的风险高于女性。
文摘Objective To systematically evaluate the effects of different forms of traditional Chinese health-preservation exercises on osteoporosis(OP)using network meta-analysis.Methods A systematic search on Excerpta Medica Database(EMBASE),Springer Link,Allied and Complementary Medicine Database(AMED),PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang)and Chongqing VIP Database(CQVIP)targeted the randomized controlled trials(RCTs)studying traditional Chinese exercises for OP published up to January 2020.Cochrane handbook was adopted to estimate the publication bias in the included studies,and statistical analysis was performed using Stata 14.0 and GeMTC 0.14.3 when data were extracted.Results Fifty RCTs were included in the network meta-analysis,comprising a total of 4505 OP patients.The network meta-analysis showed that in terms of visual analog scale(VAS)for pain,Tai Ji Quan(Tai Chi)was the most efficacious,followed by Yi Jin Jing(Sinew-transforming Qigong Exercises),Ba Duan Jin(Eight-sectioned Exercise),Wu Qin Xi(Five-animal Exercises),sports training,drug and blank control;in terms of bone mineral density(BMD)of femoral neck,Yi Jin Jing was the most efficacious,followed by Wu Qin Xi,Ba Duan Jin,Tai Ji Quan,sports training,blank control and drug;regarding the lumbar BMD,it was Yi Jin Jing,Tai Ji Quan,Ba Duan Jin,Wu Qin Xi,sports training,blank control and drug in the descending order of efficacy;in terms of serum alkaline phosphatase,it was Yi Jin Jing,Tai Ji Quan,sports training,Wu Qin Xi,Ba Duan Jin,drug and blank control in the descending order of efficacy.Conclusion The evidence to date suggests that the first choice for OP amongst the traditional Chinese exercises should be Yi Jin Jing,which can not only reduce the subjective pain,but also promote bone formation and increase BMD,though this conclusion requires more high-quality large-scale RCTs for further proof.
