Aim： To explore the possible effect of the deleted in azoospermia （DAZ） copy cluster deletion on spermatogenesis in the Chinese population, the deletion of the azoospermia factor c （AZFc） region was analyzed in 3...Aim： To explore the possible effect of the deleted in azoospermia （DAZ） copy cluster deletion on spermatogenesis in the Chinese population, the deletion of the azoospermia factor c （AZFc） region was analyzed in 346 normozoospermic men. Methods： Three DAZ single nucleotide variant loci and seven AZFc-specific sequence-tagged sites were examined with polymerase chain reaction （PCR）-restriction fragment length polymorphism and routine PCR. Results： Five （1.4%） of the normozoospermic men were found to have deletion of grlgr-DAZ1/DAZ2. None of the men were found to have b2/b4--entire DAZ deletion. Conclusion： The presence of grlgr-DAZ1/DAZ2 deletion in five men with normozoospermia suggests that this deletion per se may not be sufficient for spermatogenic impairment in Chinese men. （Asian J Androl 2006 Mar; 8： 183-187）展开更多
Idiopathic azoospermia or oligozoospermia affects approximately 2% -4% of allmarried males. Recently studies have confirmed that the deletion of DAZ in AZFc region of Ychromosome may be one of the important genetic ae...Idiopathic azoospermia or oligozoospermia affects approximately 2% -4% of allmarried males. Recently studies have confirmed that the deletion of DAZ in AZFc region of Ychromosome may be one of the important genetic aetiologies of Caucasian male infertility. Todetermine the relationship between DAZ gene deletion and idiopathic male infertility in Chinesepopulation, we analysed the DAZ gene copy number of AZFc region in patients with idiopathicazoospermia or oligozoospermia, as well as fertile Chinese men.展开更多
基金the National High Technology Research and Development Program （863 Program, China, grant numbers 2002BA711A08 and 2004AA216090） National Natural Science Foundation of China （grant number 30371491）+1 种基金 Foundation of Population and Family Planning Committee, Sichuan Province, China （grant number 200149） the China Medical Board Foundation.
文摘Aim： To explore the possible effect of the deleted in azoospermia （DAZ） copy cluster deletion on spermatogenesis in the Chinese population, the deletion of the azoospermia factor c （AZFc） region was analyzed in 346 normozoospermic men. Methods： Three DAZ single nucleotide variant loci and seven AZFc-specific sequence-tagged sites were examined with polymerase chain reaction （PCR）-restriction fragment length polymorphism and routine PCR. Results： Five （1.4%） of the normozoospermic men were found to have deletion of grlgr-DAZ1/DAZ2. None of the men were found to have b2/b4--entire DAZ deletion. Conclusion： The presence of grlgr-DAZ1/DAZ2 deletion in five men with normozoospermia suggests that this deletion per se may not be sufficient for spermatogenic impairment in Chinese men. （Asian J Androl 2006 Mar; 8： 183-187）
文摘Idiopathic azoospermia or oligozoospermia affects approximately 2% -4% of allmarried males. Recently studies have confirmed that the deletion of DAZ in AZFc region of Ychromosome may be one of the important genetic aetiologies of Caucasian male infertility. Todetermine the relationship between DAZ gene deletion and idiopathic male infertility in Chinesepopulation, we analysed the DAZ gene copy number of AZFc region in patients with idiopathicazoospermia or oligozoospermia, as well as fertile Chinese men.
