Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little...Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little attention has been paid to the changes in the motor rain within congenital amusia.In this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group.We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network.We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores.In conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia.Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination.The study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(No.WDX20180101GZ01)on February 9,2019.展开更多
目的:观察眼针疗法对脑梗塞患者神经功能缺损程度和Barthel指数的影响。方法:将80例脑梗塞患者随机分为两组,每组40例,其中治疗组采用眼针治疗,取偏瘫侧下焦区、上焦区和肾区,眶内横刺法,轻刮针柄,得气后留针15 m in;对照组采用体针治疗...目的:观察眼针疗法对脑梗塞患者神经功能缺损程度和Barthel指数的影响。方法:将80例脑梗塞患者随机分为两组,每组40例,其中治疗组采用眼针治疗,取偏瘫侧下焦区、上焦区和肾区,眶内横刺法,轻刮针柄,得气后留针15 m in;对照组采用体针治疗,取穴:曲池、外关、合谷、足三里、三阴交、太溪、太冲,普通针刺,平补平泻,留针30 m in。两组治疗均每日1次,15次一疗程。结果:共治疗2疗程后统计结果,两组神经功能缺损程度和Barthel指数积分较治疗前均明显改善(P<0.01),治疗组与对照组比较差异有统计学意义(P<0.01)。结论:采用眼针治疗能显著改善脑梗塞患者神经功能缺损程度和Barthel指数,提示眼针疗法对脑梗塞患肢功能活动和日常生活能力的干预有重要的临床意义。展开更多
基金supported by the National Natural Science Foundation of China,No.81771172(to DXW),81671671(to JL)the Second Xiangya Hospital Start-Up Fund,China。
文摘Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little attention has been paid to the changes in the motor rain within congenital amusia.In this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group.We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network.We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores.In conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia.Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination.The study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(No.WDX20180101GZ01)on February 9,2019.
文摘目的:观察眼针疗法对脑梗塞患者神经功能缺损程度和Barthel指数的影响。方法:将80例脑梗塞患者随机分为两组,每组40例,其中治疗组采用眼针治疗,取偏瘫侧下焦区、上焦区和肾区,眶内横刺法,轻刮针柄,得气后留针15 m in;对照组采用体针治疗,取穴:曲池、外关、合谷、足三里、三阴交、太溪、太冲,普通针刺,平补平泻,留针30 m in。两组治疗均每日1次,15次一疗程。结果:共治疗2疗程后统计结果,两组神经功能缺损程度和Barthel指数积分较治疗前均明显改善(P<0.01),治疗组与对照组比较差异有统计学意义(P<0.01)。结论:采用眼针治疗能显著改善脑梗塞患者神经功能缺损程度和Barthel指数,提示眼针疗法对脑梗塞患肢功能活动和日常生活能力的干预有重要的临床意义。
