In this paper,we propose a deformed Reuleaux-triangle resonator(RTR)to form exceptional point(EP)which results in the detection sensitivity enhancement of nanoparticle.After introducing single nanoparticle to the defo...In this paper,we propose a deformed Reuleaux-triangle resonator(RTR)to form exceptional point(EP)which results in the detection sensitivity enhancement of nanoparticle.After introducing single nanoparticle to the deformed RTR at EP,frequency splitting obtains an enhancement of more than 6 times compared with non-deformed RTR.In addition,EP induced a result that the far feld pattern of chiral mode responses signifcantly to external perturbation,corresponding to the change in internal chirality.Therefore,single nanoparticle with far distance of more than 4000 nm can be detected by measuring the variation of far feld directional emission.Compared to traditional frequency splitting,the far feld pattern produced in deformed RTR provides a cost-efective and convenient path to detect single nanoparticle at a long distance,without using tunable laser and external coupler.Our structure indicates great potential in high sensitivity sensor and label-free detector.展开更多
The assessment of the percentage of spermatozoa having an ＇ideal＇ morphology using so-called strict method is the method recommended in the latest edition of the World Health Organization （WHO） laboratory manual f...The assessment of the percentage of spermatozoa having an ＇ideal＇ morphology using so-called strict method is the method recommended in the latest edition of the World Health Organization （WHO） laboratory manual for semen analysis. This recommendation is a result of the statistical association between ＇ideal＇ sperm morphology and fertility, and of the current general belief that sperm morphology assessment should be used primarily as a fertility tool. The notion of an ＇ideal＇ sperm morphology has persisted despite the very low percentage of such spermatozoa in the semen of fertile men, a subject of intense controversy. The detailed categorization of each abnormal spermatozoon has thus, for a long time, been considered optional and partially redundant, an idea which is reflected in the earlier editions of the WHO manual. However, several recent studies have shown the importance of carefully assessing abnormal sperm morphology for use in the diagnosis ＆infertility, to determine fertility prognosis, and for basic or public health studies. One approach, which combines videomicroscopy and computer vision, and is the only approach able to assess the continuum of sperm biometrics, has been used successfully in several recent clinical, basic and toxicology studies. In summary, the visual assessment of detailed sperm morphology--including the categorization of anomalies allowing arithmetically derived indices of teratozoospermia--and the more modern computer-based approaches, although often considered to be redundant, are in fact complementary. The choice of the most appropriate method depends on the field of investigation （clinical, research, toxicology） and the problem being addressed. Each approach has advantages as well as certain limitations, which will be discussed briefly herein.展开更多
基金This work was supported in part by the National Natural Science Foundation of China(NSFC)(Grant Nos.62022053 and 62205192)in part by the Science and Technology Commission of Shanghai Municipality Project(22010500100,22ZR1424800)+1 种基金in part by the Open Project Program of Wuhan National Laboratory for Optoelectronics(2021WNLOKF002)and in part by the 111 Project(D20031).
文摘In this paper,we propose a deformed Reuleaux-triangle resonator(RTR)to form exceptional point(EP)which results in the detection sensitivity enhancement of nanoparticle.After introducing single nanoparticle to the deformed RTR at EP,frequency splitting obtains an enhancement of more than 6 times compared with non-deformed RTR.In addition,EP induced a result that the far feld pattern of chiral mode responses signifcantly to external perturbation,corresponding to the change in internal chirality.Therefore,single nanoparticle with far distance of more than 4000 nm can be detected by measuring the variation of far feld directional emission.Compared to traditional frequency splitting,the far feld pattern produced in deformed RTR provides a cost-efective and convenient path to detect single nanoparticle at a long distance,without using tunable laser and external coupler.Our structure indicates great potential in high sensitivity sensor and label-free detector.
文摘The assessment of the percentage of spermatozoa having an ＇ideal＇ morphology using so-called strict method is the method recommended in the latest edition of the World Health Organization （WHO） laboratory manual for semen analysis. This recommendation is a result of the statistical association between ＇ideal＇ sperm morphology and fertility, and of the current general belief that sperm morphology assessment should be used primarily as a fertility tool. The notion of an ＇ideal＇ sperm morphology has persisted despite the very low percentage of such spermatozoa in the semen of fertile men, a subject of intense controversy. The detailed categorization of each abnormal spermatozoon has thus, for a long time, been considered optional and partially redundant, an idea which is reflected in the earlier editions of the WHO manual. However, several recent studies have shown the importance of carefully assessing abnormal sperm morphology for use in the diagnosis ＆infertility, to determine fertility prognosis, and for basic or public health studies. One approach, which combines videomicroscopy and computer vision, and is the only approach able to assess the continuum of sperm biometrics, has been used successfully in several recent clinical, basic and toxicology studies. In summary, the visual assessment of detailed sperm morphology--including the categorization of anomalies allowing arithmetically derived indices of teratozoospermia--and the more modern computer-based approaches, although often considered to be redundant, are in fact complementary. The choice of the most appropriate method depends on the field of investigation （clinical, research, toxicology） and the problem being addressed. Each approach has advantages as well as certain limitations, which will be discussed briefly herein.
