S─mephenytoin and debrisoquin hydroxylation abilities were investigated in 118 normal Chinese Zhuang minority volunteers after co─administration po 100 mg racemic mephenytoin(MP)and 10 mg debrisoquin (DB). The rat...S─mephenytoin and debrisoquin hydroxylation abilities were investigated in 118 normal Chinese Zhuang minority volunteers after co─administration po 100 mg racemic mephenytoin(MP)and 10 mg debrisoquin (DB). The ratio between S─and R─enantiomers of mephenytoin in urinewas determined by implication of GC─NPD and used as the measure of the drug hydroxylation. 2 ofthe 118 subjects had S/R ratios greater than 1.0 and were poor hydroxylators of S─mephenytoin. The frequency of S─mephenytoin poor metabolizers (PM) was 10.2%. No PM of debrisoquin was found in the volunteers. It indicated that there was no relationship between S─mephenytoin P(4′)─ hydroxylation and debrisoquin 4─hydroxylation polymorphisms in Chinese Zhuang Minority population. In addition, 16 of the 118 volunteers(4 PMs and 12 EMs of S-mephenytoin) were se─lected to conduct the elimination kinetic studies of racemic mephenytoin and debrisoquin in urine. The pharmacokinetic parameters of S─, R─mephenytoin, DB and 4─OH─DB were calculated.展开更多
文摘S─mephenytoin and debrisoquin hydroxylation abilities were investigated in 118 normal Chinese Zhuang minority volunteers after co─administration po 100 mg racemic mephenytoin(MP)and 10 mg debrisoquin (DB). The ratio between S─and R─enantiomers of mephenytoin in urinewas determined by implication of GC─NPD and used as the measure of the drug hydroxylation. 2 ofthe 118 subjects had S/R ratios greater than 1.0 and were poor hydroxylators of S─mephenytoin. The frequency of S─mephenytoin poor metabolizers (PM) was 10.2%. No PM of debrisoquin was found in the volunteers. It indicated that there was no relationship between S─mephenytoin P(4′)─ hydroxylation and debrisoquin 4─hydroxylation polymorphisms in Chinese Zhuang Minority population. In addition, 16 of the 118 volunteers(4 PMs and 12 EMs of S-mephenytoin) were se─lected to conduct the elimination kinetic studies of racemic mephenytoin and debrisoquin in urine. The pharmacokinetic parameters of S─, R─mephenytoin, DB and 4─OH─DB were calculated.
