目的通过角膜中央厚度分组,观察正常眼和高眼压患者的角膜厚度和视网膜神经纤维层(RNFL)厚度之间的关系,并通过相干光断层扫描成像(OCT)和偏振激光扫描仪联合个体化角膜补偿技术(GDx-VCC)检查高眼压患者是否存在RNFL的异常,并分析OCT和G...目的通过角膜中央厚度分组,观察正常眼和高眼压患者的角膜厚度和视网膜神经纤维层(RNFL)厚度之间的关系,并通过相干光断层扫描成像(OCT)和偏振激光扫描仪联合个体化角膜补偿技术(GDx-VCC)检查高眼压患者是否存在RNFL的异常,并分析OCT和GDx-VCC测得的RNFL厚度之间的相关性。方法对眼压高于21 mm Hg(1 mm Hg=0.133 kPa)的患者测量其中央角膜厚度(CCT),根据CCT值对眼压进行校正。OCTOPUS-101自动视野仪检查及视盘观察入选高眼压组患者180只眼,均予OCT、GDx-VCC测量视盘一周视网膜神经纤维层厚度,另设正常人180只眼作为对照,获得数据进行统计学分析。结果高眼压患者的平均CCT为(536.14±35.99)(433～609)μm,正常组患者的平均CCT为(516.68±38.27)(368～598)μm。根据平均中央角膜厚度555μm分组,组间平均视网膜神经纤维层厚度(Average RNFL)、上方(S)、下方(I)的RNFL厚度以及其它参数有显著性差异,高眼压组CCT≤555μm的患者平均视网膜神经纤维层厚度要低于CCT>555μm的患者。结论高眼压患者RNFL厚度GDx-VCC与OCT的检测值低于正常人。高眼压组CCT与平均视网膜神经纤维层厚度正相关。GDx-VCC与OCT有着较好的一致性。展开更多
We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（DM）and to associate potential differences with d...We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（DM）and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized study.We measured ECD,CCT and IOP of125 patients with type 2 DM（mean age 57.1±11.5 years）and compared them with 90 age-matched controls.Measured parameters were analyzed for association with diabetes duration and glucose control modalities（insulin injection or oral medication）while controlling for age.In the diabetic group,the mean ECD（2511±252 cells/mm^2）,mean CCT（539.7±33.6μm）and mean IOP（18.3±2.5 mmHg）varied significantly from those the control group[ECD：2713±132 cells/mm^2（P〈0.0001）,CCT：525.0±45.3μm（P=0.003）and IOP：16.7±1.8 mmHg（P〈0.0001）].ECD was significantly reduced by about 32 cell/mm^2 for diabetics with duration of〉10 years when compared with those with duration of〈10 years（P〈0.05）.CCT was thicker and IOP was higher for diabetics with duration of〉10 years than those with duration of〈10 years（P〉0.05）.None of the measured parameters was significantly associated with diabetes duration and treatment modality（P〉0.05）.In conclusion,subjects with type 2DM exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications.展开更多
文摘目的通过角膜中央厚度分组,观察正常眼和高眼压患者的角膜厚度和视网膜神经纤维层(RNFL)厚度之间的关系,并通过相干光断层扫描成像(OCT)和偏振激光扫描仪联合个体化角膜补偿技术(GDx-VCC)检查高眼压患者是否存在RNFL的异常,并分析OCT和GDx-VCC测得的RNFL厚度之间的相关性。方法对眼压高于21 mm Hg(1 mm Hg=0.133 kPa)的患者测量其中央角膜厚度(CCT),根据CCT值对眼压进行校正。OCTOPUS-101自动视野仪检查及视盘观察入选高眼压组患者180只眼,均予OCT、GDx-VCC测量视盘一周视网膜神经纤维层厚度,另设正常人180只眼作为对照,获得数据进行统计学分析。结果高眼压患者的平均CCT为(536.14±35.99)(433～609)μm,正常组患者的平均CCT为(516.68±38.27)(368～598)μm。根据平均中央角膜厚度555μm分组,组间平均视网膜神经纤维层厚度(Average RNFL)、上方(S)、下方(I)的RNFL厚度以及其它参数有显著性差异,高眼压组CCT≤555μm的患者平均视网膜神经纤维层厚度要低于CCT>555μm的患者。结论高眼压患者RNFL厚度GDx-VCC与OCT的检测值低于正常人。高眼压组CCT与平均视网膜神经纤维层厚度正相关。GDx-VCC与OCT有着较好的一致性。
文摘We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（DM）and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized study.We measured ECD,CCT and IOP of125 patients with type 2 DM（mean age 57.1±11.5 years）and compared them with 90 age-matched controls.Measured parameters were analyzed for association with diabetes duration and glucose control modalities（insulin injection or oral medication）while controlling for age.In the diabetic group,the mean ECD（2511±252 cells/mm^2）,mean CCT（539.7±33.6μm）and mean IOP（18.3±2.5 mmHg）varied significantly from those the control group[ECD：2713±132 cells/mm^2（P〈0.0001）,CCT：525.0±45.3μm（P=0.003）and IOP：16.7±1.8 mmHg（P〈0.0001）].ECD was significantly reduced by about 32 cell/mm^2 for diabetics with duration of〉10 years when compared with those with duration of〈10 years（P〈0.05）.CCT was thicker and IOP was higher for diabetics with duration of〉10 years than those with duration of〈10 years（P〉0.05）.None of the measured parameters was significantly associated with diabetes duration and treatment modality（P〉0.05）.In conclusion,subjects with type 2DM exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications.
