Trade facilitation is one of the five main agendas of the Belt and Road Initiative(BRI). Social network analysis has helped understand the complexity of trade networks, but existing studies tend to overlook the fact t...Trade facilitation is one of the five main agendas of the Belt and Road Initiative(BRI). Social network analysis has helped understand the complexity of trade networks, but existing studies tend to overlook the fact that not all bilateral trade relations are equally important to a country. To fill this gap in the literature, this paper focuses on the top 2 trade relations networks to illuminate the structure and evolution of B&R trade relations, the relative positions of different countries, and changes in the composition of trade communities(e.g., the community leaders) and the changing patterns of trade between them. We find rich dynamics over time both inter-and intra-communities. The overall international trade networks of B&R countries experienced a leadership change from Russia to China on one hand, some temporary communities experienced emergence, disappearance(e.g. the Kuwait-and Thailand-led communities) or reemergence(e.g. Poland-led community), and a community membership was generally consistent on the other hand. Since the future impacts of China's BRI will depend on the degree of integration of the connected regions, some countries with stable and high centrality indices(e.g. Russia, Singapore, Serbia, Greece, Turkey, Iran, Poland, Hungary and Romania) could be selected by China as strategic regional partners, and countries with a strategically important geographical position but weak trade links(e.g. Myanmar, Pakistan, and Belarus) should be prioritized.展开更多
BACKGROUND Quantitative hepatitis B core-related antigen(qHBcrAg)has a better correlation with intrahepatic hepatitis B virus(HBV)covalently closed circular DNA(cccDNA)than HBV DNA or hepatitis B e antigen(HBeAg),but ...BACKGROUND Quantitative hepatitis B core-related antigen(qHBcrAg)has a better correlation with intrahepatic hepatitis B virus(HBV)covalently closed circular DNA(cccDNA)than HBV DNA or hepatitis B e antigen(HBeAg),but data are still lacking for its clinical application.AIM The aim was to investigate serum qHBcrAg levels in patients with chronic hepatitis B and assess the correlation of serum qHBcrAg with pregenomic RNA(pgRNA),cccDNA,and HBeAg seroconversion.METHODS This study was a secondary analysis of patients who underwent percutaneous liver biopsy between July 2014 and June 2019 in two multicenter randomized controlled clinical trials of peginterferon vs nucleos(t)ide analog(NUC)-based therapy(NCT03509688 and NCT03546530).Serum qHBcrAg,pgRNA,HBV DNA,hepatitis B core antigen,HBeAg,liver cccDNA,and HBV DNA were measured.The correlations of serum qHBcrAg with other biomarkers were analyzed.RESULTS A total of 139 patients were included.The mean qHBcrAg levels were 5.32±1.18 log10 U/mL at baseline and decreased during treatment(all P<0.0001).Serum qHBcrAg levels were positively correlated with pgRNA(r=0.597,P<0.0001)and cccDNA(r=0.527,P<0.0001)levels.The correlation of serum qHBcrAg level and intrahepatic HBV DNA levels at baseline was weak but significant(r=0.399,P<0.0001).HBcrAg predicted HBeAg seroconversion,with areas under the receiver operating characteristics curve of 0.788 at 24 wk and 0.825 at 48 wk.Log HBcrAg at wk 24 and 48 was independently associated with HBeAg seroconversion[odds ratio(OR)=2.402,95%confidence interval(CI):1.314-4.391,P=0.004;OR=3.587,95%CI:1.315-9.784,P=0.013].CONCLUSION Serum HBcrAg levels were correlated with HBV virological markers and could be used to predict HBeAg seroconversion.展开更多
基金National Social Science Foundation of China,No.17VDL008The Project of Bureau of International Cooperation of the Chinese Academy of Sciences,No.131A11KYSB20170014+1 种基金National Natural Science Foundation of China,No.41530751,No.41471113,No.41701125Ministry of Education of the Republic of Korea and the National Research Foundation of Korea,No.NRF-2015S1A3A2047036
文摘Trade facilitation is one of the five main agendas of the Belt and Road Initiative(BRI). Social network analysis has helped understand the complexity of trade networks, but existing studies tend to overlook the fact that not all bilateral trade relations are equally important to a country. To fill this gap in the literature, this paper focuses on the top 2 trade relations networks to illuminate the structure and evolution of B&R trade relations, the relative positions of different countries, and changes in the composition of trade communities(e.g., the community leaders) and the changing patterns of trade between them. We find rich dynamics over time both inter-and intra-communities. The overall international trade networks of B&R countries experienced a leadership change from Russia to China on one hand, some temporary communities experienced emergence, disappearance(e.g. the Kuwait-and Thailand-led communities) or reemergence(e.g. Poland-led community), and a community membership was generally consistent on the other hand. Since the future impacts of China's BRI will depend on the degree of integration of the connected regions, some countries with stable and high centrality indices(e.g. Russia, Singapore, Serbia, Greece, Turkey, Iran, Poland, Hungary and Romania) could be selected by China as strategic regional partners, and countries with a strategically important geographical position but weak trade links(e.g. Myanmar, Pakistan, and Belarus) should be prioritized.
基金by National Science and Technology Major Project,No.2017ZX10302201,No.2017ZX09304004 and No.2014ZX10002002National Program on Key Basic Research Project(973 Program),No.2015CB554304.
文摘BACKGROUND Quantitative hepatitis B core-related antigen(qHBcrAg)has a better correlation with intrahepatic hepatitis B virus(HBV)covalently closed circular DNA(cccDNA)than HBV DNA or hepatitis B e antigen(HBeAg),but data are still lacking for its clinical application.AIM The aim was to investigate serum qHBcrAg levels in patients with chronic hepatitis B and assess the correlation of serum qHBcrAg with pregenomic RNA(pgRNA),cccDNA,and HBeAg seroconversion.METHODS This study was a secondary analysis of patients who underwent percutaneous liver biopsy between July 2014 and June 2019 in two multicenter randomized controlled clinical trials of peginterferon vs nucleos(t)ide analog(NUC)-based therapy(NCT03509688 and NCT03546530).Serum qHBcrAg,pgRNA,HBV DNA,hepatitis B core antigen,HBeAg,liver cccDNA,and HBV DNA were measured.The correlations of serum qHBcrAg with other biomarkers were analyzed.RESULTS A total of 139 patients were included.The mean qHBcrAg levels were 5.32±1.18 log10 U/mL at baseline and decreased during treatment(all P<0.0001).Serum qHBcrAg levels were positively correlated with pgRNA(r=0.597,P<0.0001)and cccDNA(r=0.527,P<0.0001)levels.The correlation of serum qHBcrAg level and intrahepatic HBV DNA levels at baseline was weak but significant(r=0.399,P<0.0001).HBcrAg predicted HBeAg seroconversion,with areas under the receiver operating characteristics curve of 0.788 at 24 wk and 0.825 at 48 wk.Log HBcrAg at wk 24 and 48 was independently associated with HBeAg seroconversion[odds ratio(OR)=2.402,95%confidence interval(CI):1.314-4.391,P=0.004;OR=3.587,95%CI:1.315-9.784,P=0.013].CONCLUSION Serum HBcrAg levels were correlated with HBV virological markers and could be used to predict HBeAg seroconversion.
