为研究雾滴尺寸对药液沉积和麦蚜防效的影响,该试验通过选择不同喷头喷施吡虫啉来防治麦蚜。所选德国Lechler生产的3种喷头(LU120-02、AD120-02和IDK120-02)的VMD(volume median diameter,VMD)相差约100μm。试验结果表明:IDK喷头在小...为研究雾滴尺寸对药液沉积和麦蚜防效的影响,该试验通过选择不同喷头喷施吡虫啉来防治麦蚜。所选德国Lechler生产的3种喷头(LU120-02、AD120-02和IDK120-02)的VMD(volume median diameter,VMD)相差约100μm。试验结果表明:IDK喷头在小麦冠层的平均沉积量显著小于LU和AD,而LU和AD这2个喷头之间没有显著差异性,3种喷头在冠层下部的药液沉积量>中部>上部;LU喷头喷施的药液平均覆盖率显著好于AD和IDK,覆盖率随着雾滴粒径的增加而递减;LU喷头喷施的药液的地面损失最大,且显著高于其他两种喷头;3种喷头都体现了对麦蚜的良好防效;从沉积量、沉积均匀性及地面损失量来衡量,AD喷头优于其他2种喷头。展开更多
Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building ef...Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in crystal engineering and crystallization process design and control in the pharmaceutical industry. We systematically summarize recent methods for understanding and developing new types of crystals such as co-crystals, polymorphs, and solvates, and include several milestones such as the launch of the first co-crystal drug, Entresto （No- vartis）, and the continuous manufacture of Orkambi （Vertex）. Conventional batch and continuous processes, which are becoming increasingly mature, are being coupled with various control strategies and the recently developed crystallizers are thus adapting to the needs of the pharmaceutical industry. The development of crystallization process design and control has led to the appearance of several new and innovative crystal- lizer geometries for continuous operation and improved performance. This paper also reviews major recent orogress in the area of process analytical technology.展开更多
文摘为研究雾滴尺寸对药液沉积和麦蚜防效的影响,该试验通过选择不同喷头喷施吡虫啉来防治麦蚜。所选德国Lechler生产的3种喷头(LU120-02、AD120-02和IDK120-02)的VMD(volume median diameter,VMD)相差约100μm。试验结果表明:IDK喷头在小麦冠层的平均沉积量显著小于LU和AD,而LU和AD这2个喷头之间没有显著差异性,3种喷头在冠层下部的药液沉积量>中部>上部;LU喷头喷施的药液平均覆盖率显著好于AD和IDK,覆盖率随着雾滴粒径的增加而递减;LU喷头喷施的药液的地面损失最大,且显著高于其他两种喷头;3种喷头都体现了对麦蚜的良好防效;从沉积量、沉积均匀性及地面损失量来衡量,AD喷头优于其他2种喷头。
文摘Crystallization is one of the oldest separation and purification unit operations, and has recently contributed to significant improvements in producing higher-value products with specific properties and in building efficient manufacturing processes. In this paper, we review recent developments in crystal engineering and crystallization process design and control in the pharmaceutical industry. We systematically summarize recent methods for understanding and developing new types of crystals such as co-crystals, polymorphs, and solvates, and include several milestones such as the launch of the first co-crystal drug, Entresto （No- vartis）, and the continuous manufacture of Orkambi （Vertex）. Conventional batch and continuous processes, which are becoming increasingly mature, are being coupled with various control strategies and the recently developed crystallizers are thus adapting to the needs of the pharmaceutical industry. The development of crystallization process design and control has led to the appearance of several new and innovative crystal- lizer geometries for continuous operation and improved performance. This paper also reviews major recent orogress in the area of process analytical technology.
