The Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway was discovered more than a quarter-century ago.As a fulcrum of many vital cellular processes,the JAK/STAT pathway constitute...The Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway was discovered more than a quarter-century ago.As a fulcrum of many vital cellular processes,the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation.Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases.In this review,we discuss the current knowledge about the composition,activation,and regulation of the JAK/STAT pathway.Moreover,we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.展开更多
基金This work was supported by the National Key Research and Development Program of China(2020YFC0860200)Key Research and Development Program of Sichuan Province(2020YFS0008)the National Natural Science Foundation of China(No.81902662)。
文摘The Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway was discovered more than a quarter-century ago.As a fulcrum of many vital cellular processes,the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation.Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases.In this review,we discuss the current knowledge about the composition,activation,and regulation of the JAK/STAT pathway.Moreover,we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.
