短波长、高光子能量的Ar F准分子激光在集成电路光刻、材料加工、激光医学等领域具有重要的应用。结合线宽压窄技术方案设计了193 nm Ar F准分子激光器复合腔结构,理论分析了复合腔结构能量提升的原理。针对准分子激光器的长腔特性,提...短波长、高光子能量的Ar F准分子激光在集成电路光刻、材料加工、激光医学等领域具有重要的应用。结合线宽压窄技术方案设计了193 nm Ar F准分子激光器复合腔结构,理论分析了复合腔结构能量提升的原理。针对准分子激光器的长腔特性,提出了实现其复合腔窄带激光模式锁定的解决方案,并进行了实验验证。与通常插入色散元件的单窄带腔相比,锁定后的准分子激光复合腔在输出线宽基本不变的情况下能量提高了4.02倍,激光效率大幅提升,能量稳定性也大幅优化。展开更多
Many emerging strategies in chemo-,gene-,and immunotherapy require the accumulation of reagents in the cell nucleus.However,their delivery into the nucleus is often limited.Nuclear delivery could be enhanced with a ra...Many emerging strategies in chemo-,gene-,and immunotherapy require the accumulation of reagents in the cell nucleus.However,their delivery into the nucleus is often limited.Nuclear delivery could be enhanced with a rationally designed cargo-delivery scaffold,but this approach has rarely been successfully implemented.Herein,a stable,biocompatible molecular capsule that encapsulates and delivers camptothecin,a DNA topoisomerase I inhibitor,into the nucleus of living cells was reported.Nuclear delivery is facilitated by the ultra-small diameter,zero net charge,and hydrophobicity of the capsule.The encapsulated drug complex displays superior toxicity towards multiple cancer cells over the free drug,the Food and Drug Administration(FDA)approved drugs,as well as conventionally reported drug vectors.Additionally,it inhibits liver cancer tumor growth in a xenograft mouse model.Modification of the properties of such molecular capsules may make it possible to design therapeutic strategies that target specific cell organelles.展开更多
A Michelson interferometer(MI) composite cavity fiber laser sensing system based on radio frequency(RF) interrogation is proposed and experimentally demonstrated. The system down-converts the traditional MI light freq...A Michelson interferometer(MI) composite cavity fiber laser sensing system based on radio frequency(RF) interrogation is proposed and experimentally demonstrated. The system down-converts the traditional MI light frequency detection to RF detection, which improves the stability of the system. The optic fiber MI is placed in the laser resonator to form a composite cavity structure, which greatly improves the sensitivity of beat frequency signal demodulation.展开更多
文摘短波长、高光子能量的Ar F准分子激光在集成电路光刻、材料加工、激光医学等领域具有重要的应用。结合线宽压窄技术方案设计了193 nm Ar F准分子激光器复合腔结构,理论分析了复合腔结构能量提升的原理。针对准分子激光器的长腔特性,提出了实现其复合腔窄带激光模式锁定的解决方案,并进行了实验验证。与通常插入色散元件的单窄带腔相比,锁定后的准分子激光复合腔在输出线宽基本不变的情况下能量提高了4.02倍,激光效率大幅提升,能量稳定性也大幅优化。
基金the National Natural Science Foundation of China(No.22071049)the fund from China Hunan Provincial Science&Technology Department(No.2020RC3020)。
文摘Many emerging strategies in chemo-,gene-,and immunotherapy require the accumulation of reagents in the cell nucleus.However,their delivery into the nucleus is often limited.Nuclear delivery could be enhanced with a rationally designed cargo-delivery scaffold,but this approach has rarely been successfully implemented.Herein,a stable,biocompatible molecular capsule that encapsulates and delivers camptothecin,a DNA topoisomerase I inhibitor,into the nucleus of living cells was reported.Nuclear delivery is facilitated by the ultra-small diameter,zero net charge,and hydrophobicity of the capsule.The encapsulated drug complex displays superior toxicity towards multiple cancer cells over the free drug,the Food and Drug Administration(FDA)approved drugs,as well as conventionally reported drug vectors.Additionally,it inhibits liver cancer tumor growth in a xenograft mouse model.Modification of the properties of such molecular capsules may make it possible to design therapeutic strategies that target specific cell organelles.
基金This work was supported by the National Natural Science Foundation of China(NSFC)(No.62075057)the Program for Innovative Research Team(in Science and Technology)in University of Henan Province(No.21IRTSTHN011).
文摘A Michelson interferometer(MI) composite cavity fiber laser sensing system based on radio frequency(RF) interrogation is proposed and experimentally demonstrated. The system down-converts the traditional MI light frequency detection to RF detection, which improves the stability of the system. The optic fiber MI is placed in the laser resonator to form a composite cavity structure, which greatly improves the sensitivity of beat frequency signal demodulation.
