目的采用meta分析方法评价超声造影引导射频消融治疗肝癌的疗效及安全性。方法检索收集Pubmed、Embase、Web of Science、Cochrane Library、中国知网(CNKI)、维普、万方数据库建库至2023年7月20日发表的有关应用超声造影引导射频消融(...目的采用meta分析方法评价超声造影引导射频消融治疗肝癌的疗效及安全性。方法检索收集Pubmed、Embase、Web of Science、Cochrane Library、中国知网(CNKI)、维普、万方数据库建库至2023年7月20日发表的有关应用超声造影引导射频消融(试验组)与常规超声或增强CT引导射频消融(对照组)治疗肝癌的临床对照试验研究,将纳入的数据进行meta分析。结果共纳入文献8篇,共879例患者。meta分析显示,两组肿瘤完全消融率(OR=2.96,95%CI:2.13~4.11,P<0.01)、复发率(OR=0.35,95%CI:0.22~0.55,P<0.01)、术后并发症发生率(OR=0.49,95%CI:0.32~0.76,P<0.01)差异有统计学意义。结论超声造影引导射频消融治疗肝癌较常规超声或增强CT疗效更明显。展开更多
Objective To compare the value of contrast-enhanced ultrasound(CEUS)and conventional ultrasound(US)during radiofrequency ablation(RFA)for the treatment of hepatocellular carcinoma(HCC)≥3.0 cm in diameter.Methods A to...Objective To compare the value of contrast-enhanced ultrasound(CEUS)and conventional ultrasound(US)during radiofrequency ablation(RFA)for the treatment of hepatocellular carcinoma(HCC)≥3.0 cm in diameter.Methods A total of 149 HCC patients treated with RFA guided by either CEUS or conventional US between January 2012 and June 2013 were retrospectively analyzed.Patients were divided into different groups based on the type of ultrasound guidance(CEUS or conventional US)and tumor volume(diameter<3.0 or≥3.0 cm).The progressionfree survival(PFS)and complete ablation rates were compared between groups,and risk factors for the PFS were investigated.Results Seventy four patients received CEUS-guided RFA,and conventional US was performed in 75 patients.Among patients with a tumor<3.0 cm,the PFS and complete ablation rates were similar.However,for patients with a tumor≥3.0 cm,those treated with CEUS had a significantly longer PFS(17.3 vs.3.1 months,HR=2.73;95%CI,1.28~5.81;P=0.007)and higher complete ablation rates at 6-and 12-month post-treatment(87.5%vs.57.7%,P=0.042;75.0%vs.38.5%,P=0.009,respectively)than those treated with conventional US-guided RFA.The type of treatment(P=0.024)and maximum tumour size(P=0.011)were both found to be independent factors associated with the PFS.Conclusion Compared with conventional US,CEUS is more effective for guiding RFA in patients with HCC≥3.0 cm.CEUS-guided RFA could target HCC more accurately,and its ability to immediately detect any residual tumor during RFA might contribute to an increase in complete ablation rates and reduced progression.展开更多
文摘目的采用meta分析方法评价超声造影引导射频消融治疗肝癌的疗效及安全性。方法检索收集Pubmed、Embase、Web of Science、Cochrane Library、中国知网(CNKI)、维普、万方数据库建库至2023年7月20日发表的有关应用超声造影引导射频消融(试验组)与常规超声或增强CT引导射频消融(对照组)治疗肝癌的临床对照试验研究,将纳入的数据进行meta分析。结果共纳入文献8篇,共879例患者。meta分析显示,两组肿瘤完全消融率(OR=2.96,95%CI:2.13~4.11,P<0.01)、复发率(OR=0.35,95%CI:0.22~0.55,P<0.01)、术后并发症发生率(OR=0.49,95%CI:0.32~0.76,P<0.01)差异有统计学意义。结论超声造影引导射频消融治疗肝癌较常规超声或增强CT疗效更明显。
基金the Training Plan for Outstanding Young Teachers of Jilin University(No.419080500356).
文摘Objective To compare the value of contrast-enhanced ultrasound(CEUS)and conventional ultrasound(US)during radiofrequency ablation(RFA)for the treatment of hepatocellular carcinoma(HCC)≥3.0 cm in diameter.Methods A total of 149 HCC patients treated with RFA guided by either CEUS or conventional US between January 2012 and June 2013 were retrospectively analyzed.Patients were divided into different groups based on the type of ultrasound guidance(CEUS or conventional US)and tumor volume(diameter<3.0 or≥3.0 cm).The progressionfree survival(PFS)and complete ablation rates were compared between groups,and risk factors for the PFS were investigated.Results Seventy four patients received CEUS-guided RFA,and conventional US was performed in 75 patients.Among patients with a tumor<3.0 cm,the PFS and complete ablation rates were similar.However,for patients with a tumor≥3.0 cm,those treated with CEUS had a significantly longer PFS(17.3 vs.3.1 months,HR=2.73;95%CI,1.28~5.81;P=0.007)and higher complete ablation rates at 6-and 12-month post-treatment(87.5%vs.57.7%,P=0.042;75.0%vs.38.5%,P=0.009,respectively)than those treated with conventional US-guided RFA.The type of treatment(P=0.024)and maximum tumour size(P=0.011)were both found to be independent factors associated with the PFS.Conclusion Compared with conventional US,CEUS is more effective for guiding RFA in patients with HCC≥3.0 cm.CEUS-guided RFA could target HCC more accurately,and its ability to immediately detect any residual tumor during RFA might contribute to an increase in complete ablation rates and reduced progression.
