目的研究达格列净联合二甲双胍治疗肥胖2型糖尿病及对血清补体、氧化应激因子和血液流变学的影响。方法前瞻性选取2015年7月至2020年6月洪湖市人民医院收治的肥胖2型糖尿病患者136例,按照随机数字表法分为达格列净组(n=68)、对照组(n=68...目的研究达格列净联合二甲双胍治疗肥胖2型糖尿病及对血清补体、氧化应激因子和血液流变学的影响。方法前瞻性选取2015年7月至2020年6月洪湖市人民医院收治的肥胖2型糖尿病患者136例,按照随机数字表法分为达格列净组(n=68)、对照组(n=68)。对照组给予吡格列酮+二甲双胍治疗,达格列净组给予达格列净+二甲双胍治疗。观察2组治疗前、治疗后3个月糖化血红蛋白(HbA1c)、空腹血糖(FPG)及餐后2 h血糖(2 h PG)等血糖指标。总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)等血脂指标。血清C3、C4等补体水平,谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)及丙二醛(MDA)等氧化应激因子水平,纤维蛋白原(Fib)、全血黏度低切(BVL)、全血黏度高切(BVH)及血浆黏度(PV)等血液流变学指标。结果治疗后3个月,达格列净组HbA1c、FPG、2 h PG为(6.01±0.63)%、(5.01±0.52)mmol/L、(7.52±0.78)mmol/L,均显著低于对照组[(6.33±0.66)%、(5.27±0.54)mmol/L、(7.98±0.82)mmol/L],差异均有统计学意义(P<0.05)。达格列净组TC、TG及LDL-C水平分别为(3.19±0.34)、(1.39±0.15)、(2.08±0.22)mmol/L,均显著低于对照组[(3.37±0.36)、(1.48±0.17)、(2.21±0.25)mmol/L],差异均有统计学意义(P<0.05)。达格列净组血清C3、C4、MDA水平分别为(1.20±0.13)g/L、(0.33±0.03)g/L、(3.01±0.32)mmol/L,均显著低于对照组[(1.27±0.14)g/L、(0.35±0.04)g/L、(3.18±0.34)mmol/L],血清GSH-PX、SOD水平分别为(110.72±13.07)pg/mL、(94.07±9.62)UL,均显著高于对照组[(104.86±11.21)pg/mL、(89.62±9.14)U/L],差异均有统计学意义(P<0.05)。达格列净组Fib、BVL、BVH及PV分别为(1.80±0.21)g/L、(8.80±0.91)mPa·s、(4.39±0.45)mPa·s、(1.26±0.14)mPa·s,均低于对照组[(1.92±0.22)g/L、(9.22±0.94)mPa·s、(4.62±0.48)mPa·s、(1.34±0.15)mPa·s],差异均有统计学意义(P<0.05)。结论达格列净联合二甲双胍治疗肥胖2型糖尿病可有效降低血糖、血脂水平,纠展开更多
The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the ...The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the pathogen as well as in the generation of the classical inflammatory response through the production of potent proinflammatory molecules. More recently, however, the role of complement in the immune response has been expanded due to observations that link complement activation to adaptive immune responses. It is now appreciated that complement is a functional bridge between innate and adaptive immune responses that allows an integrated host defense to pathogenic challenges. As such, a study of its functions allows insight into the molecular underpinnings of host-pathogen interactions as well as the organization and orchestration of the host immune response. This review attempts to summarize the roles that complement plays in both innate and adaptive immune responses and the consequences of these interactions on host defense.展开更多
文摘目的研究达格列净联合二甲双胍治疗肥胖2型糖尿病及对血清补体、氧化应激因子和血液流变学的影响。方法前瞻性选取2015年7月至2020年6月洪湖市人民医院收治的肥胖2型糖尿病患者136例,按照随机数字表法分为达格列净组(n=68)、对照组(n=68)。对照组给予吡格列酮+二甲双胍治疗,达格列净组给予达格列净+二甲双胍治疗。观察2组治疗前、治疗后3个月糖化血红蛋白(HbA1c)、空腹血糖(FPG)及餐后2 h血糖(2 h PG)等血糖指标。总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)等血脂指标。血清C3、C4等补体水平,谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)及丙二醛(MDA)等氧化应激因子水平,纤维蛋白原(Fib)、全血黏度低切(BVL)、全血黏度高切(BVH)及血浆黏度(PV)等血液流变学指标。结果治疗后3个月,达格列净组HbA1c、FPG、2 h PG为(6.01±0.63)%、(5.01±0.52)mmol/L、(7.52±0.78)mmol/L,均显著低于对照组[(6.33±0.66)%、(5.27±0.54)mmol/L、(7.98±0.82)mmol/L],差异均有统计学意义(P<0.05)。达格列净组TC、TG及LDL-C水平分别为(3.19±0.34)、(1.39±0.15)、(2.08±0.22)mmol/L,均显著低于对照组[(3.37±0.36)、(1.48±0.17)、(2.21±0.25)mmol/L],差异均有统计学意义(P<0.05)。达格列净组血清C3、C4、MDA水平分别为(1.20±0.13)g/L、(0.33±0.03)g/L、(3.01±0.32)mmol/L,均显著低于对照组[(1.27±0.14)g/L、(0.35±0.04)g/L、(3.18±0.34)mmol/L],血清GSH-PX、SOD水平分别为(110.72±13.07)pg/mL、(94.07±9.62)UL,均显著高于对照组[(104.86±11.21)pg/mL、(89.62±9.14)U/L],差异均有统计学意义(P<0.05)。达格列净组Fib、BVL、BVH及PV分别为(1.80±0.21)g/L、(8.80±0.91)mPa·s、(4.39±0.45)mPa·s、(1.26±0.14)mPa·s,均低于对照组[(1.92±0.22)g/L、(9.22±0.94)mPa·s、(4.62±0.48)mPa·s、(1.34±0.15)mPa·s],差异均有统计学意义(P<0.05)。结论达格列净联合二甲双胍治疗肥胖2型糖尿病可有效降低血糖、血脂水平,纠
文摘The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the pathogen as well as in the generation of the classical inflammatory response through the production of potent proinflammatory molecules. More recently, however, the role of complement in the immune response has been expanded due to observations that link complement activation to adaptive immune responses. It is now appreciated that complement is a functional bridge between innate and adaptive immune responses that allows an integrated host defense to pathogenic challenges. As such, a study of its functions allows insight into the molecular underpinnings of host-pathogen interactions as well as the organization and orchestration of the host immune response. This review attempts to summarize the roles that complement plays in both innate and adaptive immune responses and the consequences of these interactions on host defense.
