Purpose:Lens coloboma is a rare congenital disorder of crystalline lens characterized by notching of the equator of the lens.Coloboma can occur in isolation or with other ocular malformations. The authors reported 5 c...Purpose:Lens coloboma is a rare congenital disorder of crystalline lens characterized by notching of the equator of the lens.Coloboma can occur in isolation or with other ocular malformations. The authors reported 5 cases of lens coloboma associated with some ocular malformations. Methods:Case reports.The clinical features,imaging findings and associated ocular malformations were reported. Results:One case was not associated with ocular anomalies. One patient was involved with iris and choroid coloboma;another subject suffered from total cataract;and the fourth patient was affected by lens dislocation.The remaining case included aniridia. The pathogenic mechanisms and relationship of the ocular malformations have been discussed. Conclusion:Lens coloboma can be associated with other ocular malformations, such as iris coloboma, choroid colobma, localized or total caratact.展开更多
<strong>Background:</strong> Ocular coloboma is the product of an error in the fetal fissure closure, normally occurring between the fifth and sixth weeks of gestation <a href="#R1" target=&qu...<strong>Background:</strong> Ocular coloboma is the product of an error in the fetal fissure closure, normally occurring between the fifth and sixth weeks of gestation <a href="#R1" target="_blank">[1]</a>. It may involve the cornea, iris, zonula, ciliary body, choroid, retina and optic nerve. The incidence of this syndrome is 0.7 per 10,000 live-births <a href="#R1" target="_blank">[1]</a>. The aim of this observation is to present the first case of bilateral coloboma of the iris <a href="#R1" target="_blank">[1]</a>. This case was associated with an ametropia causing a decrease in visual acuity. <strong>Case Presentation:</strong> This was a clinical observation concerning a young 12-year-old patient who consulted for blurring of vision which had progressed for approximately 2 years. The ophthalmologic examination revealed an ametropia with a bilateral notch of the pupillary rim suggesting a bilateral coloboma. There was no association with another coloboma such as chorioretinal coloboma which is quite common and is accompanied frequently by visual symptoms. <strong>Conclusion:</strong> A visual impairment of the child can indicate ametropia. However, other congenital anomalies can be discovered as was the case in this clinical observation.展开更多
基金Natural Science Foundation of YunnanProvince(No.2009ZC175M)
文摘Purpose:Lens coloboma is a rare congenital disorder of crystalline lens characterized by notching of the equator of the lens.Coloboma can occur in isolation or with other ocular malformations. The authors reported 5 cases of lens coloboma associated with some ocular malformations. Methods:Case reports.The clinical features,imaging findings and associated ocular malformations were reported. Results:One case was not associated with ocular anomalies. One patient was involved with iris and choroid coloboma;another subject suffered from total cataract;and the fourth patient was affected by lens dislocation.The remaining case included aniridia. The pathogenic mechanisms and relationship of the ocular malformations have been discussed. Conclusion:Lens coloboma can be associated with other ocular malformations, such as iris coloboma, choroid colobma, localized or total caratact.
文摘<strong>Background:</strong> Ocular coloboma is the product of an error in the fetal fissure closure, normally occurring between the fifth and sixth weeks of gestation <a href="#R1" target="_blank">[1]</a>. It may involve the cornea, iris, zonula, ciliary body, choroid, retina and optic nerve. The incidence of this syndrome is 0.7 per 10,000 live-births <a href="#R1" target="_blank">[1]</a>. The aim of this observation is to present the first case of bilateral coloboma of the iris <a href="#R1" target="_blank">[1]</a>. This case was associated with an ametropia causing a decrease in visual acuity. <strong>Case Presentation:</strong> This was a clinical observation concerning a young 12-year-old patient who consulted for blurring of vision which had progressed for approximately 2 years. The ophthalmologic examination revealed an ametropia with a bilateral notch of the pupillary rim suggesting a bilateral coloboma. There was no association with another coloboma such as chorioretinal coloboma which is quite common and is accompanied frequently by visual symptoms. <strong>Conclusion:</strong> A visual impairment of the child can indicate ametropia. However, other congenital anomalies can be discovered as was the case in this clinical observation.
