Clomiphene citrate(CC) has been shown to be effective in ovulation induction.However,the high ovulation rate and low pregnancy rate during CC treatment have not been resolved for a long time.As more and more drugs hav...Clomiphene citrate(CC) has been shown to be effective in ovulation induction.However,the high ovulation rate and low pregnancy rate during CC treatment have not been resolved for a long time.As more and more drugs have been explored for induction of ovulation,it is questioned about its first line drug in the treatment of anovulation.In this paper we reviewed the use of CC for ovulation induction.Data about use of other drugs for induction of ovulation were also introduced here.In conclusion,CC is still the first choice for ovulation induction for its effectiveness,safety and low price.展开更多
目的:探讨二甲双胍联合克罗米芬对多囊卵巢综合征所致不孕症患者胰岛素抵抗指数(homeostasis model assessment for insulin resistance,HOMA-IR)、激素水平的影响。方法:选取2016年1月至2017年7月郑州市妇幼保健院收治的多囊卵巢综合...目的:探讨二甲双胍联合克罗米芬对多囊卵巢综合征所致不孕症患者胰岛素抵抗指数(homeostasis model assessment for insulin resistance,HOMA-IR)、激素水平的影响。方法:选取2016年1月至2017年7月郑州市妇幼保健院收治的多囊卵巢综合征所致不孕症患者80例作为研究对象,以随机数字表法分为观察组和对照组,每组40例。观察组患者给予二甲双胍联合克罗米芬治疗,对照组患者仅给予克罗米芬治疗。比较两组患者HOMA-IR、激素水平[卵泡刺激素(FSH)、空腹胰岛素(FINS)、黄体生成素(LH)、睾酮(T)和雌二醇(E2)]、排卵情况、妊娠情况及妊娠早期流产情况的差异。结果:治疗后,观察组、对照组患者平均HOMA-IR分别为1.44±0.30、2.06±0.36,均明显低于治疗前,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者FSH、FINS、LH及T水平较治疗前明显降低,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05);两组患者E2水平的差异无统计学意义(P>0.05)。观察组患者的排卵率、妊娠率明显高于对照组,妊娠早期流产率明显低于对照组,差异均有统计学意义(P<0.05)。结论:二甲双胍联合克罗米芬能显著改善多囊卵巢综合征所致不孕症患者的HOMA-IR和激素水平,促进排卵,提高妊娠率。展开更多
文摘Clomiphene citrate(CC) has been shown to be effective in ovulation induction.However,the high ovulation rate and low pregnancy rate during CC treatment have not been resolved for a long time.As more and more drugs have been explored for induction of ovulation,it is questioned about its first line drug in the treatment of anovulation.In this paper we reviewed the use of CC for ovulation induction.Data about use of other drugs for induction of ovulation were also introduced here.In conclusion,CC is still the first choice for ovulation induction for its effectiveness,safety and low price.
文摘目的:探讨二甲双胍联合克罗米芬对多囊卵巢综合征所致不孕症患者胰岛素抵抗指数(homeostasis model assessment for insulin resistance,HOMA-IR)、激素水平的影响。方法:选取2016年1月至2017年7月郑州市妇幼保健院收治的多囊卵巢综合征所致不孕症患者80例作为研究对象,以随机数字表法分为观察组和对照组,每组40例。观察组患者给予二甲双胍联合克罗米芬治疗,对照组患者仅给予克罗米芬治疗。比较两组患者HOMA-IR、激素水平[卵泡刺激素(FSH)、空腹胰岛素(FINS)、黄体生成素(LH)、睾酮(T)和雌二醇(E2)]、排卵情况、妊娠情况及妊娠早期流产情况的差异。结果:治疗后,观察组、对照组患者平均HOMA-IR分别为1.44±0.30、2.06±0.36,均明显低于治疗前,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者FSH、FINS、LH及T水平较治疗前明显降低,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05);两组患者E2水平的差异无统计学意义(P>0.05)。观察组患者的排卵率、妊娠率明显高于对照组,妊娠早期流产率明显低于对照组,差异均有统计学意义(P<0.05)。结论:二甲双胍联合克罗米芬能显著改善多囊卵巢综合征所致不孕症患者的HOMA-IR和激素水平,促进排卵,提高妊娠率。
