BACKGROUND Nucleos(t)ide analog(NA)has shown limited effectiveness against hepatitis B surface antigen(HBsAg)clearance in chronic hepatitis B(CHB)patients.AIM To evaluate the efficacy and safety of add-on peginterfero...BACKGROUND Nucleos(t)ide analog(NA)has shown limited effectiveness against hepatitis B surface antigen(HBsAg)clearance in chronic hepatitis B(CHB)patients.AIM To evaluate the efficacy and safety of add-on peginterferonα-2a(peg-IFNα-2a)to an ongoing NA regimen in CHB patients.METHODS In this observational study,195 CHB patients with HBsAg≤1500 IU/m L,hepatitis B e antigen(HBeAg)-negative(including HBeAg-negative patients or HBeAg-positive patients who achieved HBeAg-negative after antiviral treatment with NA)and hepatitis B virus-deoxyribonucleic acid<1.0×10^2 IU/mL after over 1 year of NA therapy were enrolled between November 2015 and December2018 at the Second Affiliated Hospital of Xi'an Jiaotong University,China.Patients were given the choice between receiving either peg-IFNα-2a add-on therapy to an ongoing NA regimen(add-on group,n=91)or continuous NA monotherapy(monotherapy group,n=104)after being informed of the benefits and risks of the peg-IFNα-2a therapy.Total therapy duration of peg-IFNα-2a was 48 wk.All patients were followed-up to week 72(24 wk after discontinuation of peg-IFNα-2a).The primary endpoint was the proportion of patients with HBsAg clearance at week 72.RESULTS Demographic and baseline characteristics were comparable between the two groups.Intention-to-treatment analysis showed that the HBsAg clearance rate in the add-on group and monotherapy group was 37.4%(34/91)and 1.9%(2/104)at week 72,respectively.The HBsAg seroconversion rate in the add-on group was 29.7%(27/91)at week 72,and no patient in the monotherapy group achieved HBsAg seroconversion at week 72.The HBsAg clearance and seroconversion rates in the add-on group were significantly higher than in the monotherapy group at week 72(P<0.001).Younger patients,lower baseline HBsAg concentration,lower HBsAg concentrations at weeks 12 and 24,greater HBsAg decline from baseline to weeks 12 and 24 and the alanine aminotransferase≥2×upper limit of normal during the first 12 wk of therapy were strong predictors of HBsAg clearance i展开更多
Hepatitis B virus (HBV) is a common viral pathogen that causes a substantial health burden worldwide. Remarkable progress has been made in our understanding of the natural stages of chronic HBV infection. A dynamic ba...Hepatitis B virus (HBV) is a common viral pathogen that causes a substantial health burden worldwide. Remarkable progress has been made in our understanding of the natural stages of chronic HBV infection. A dynamic balance between viral replication and host immune response is pivotal to the pathogenesis of liver disease. Knowledge of the HBV genome organization and replication cycle can unravel HBV genotypes and molecular variants, which contribute to the heterogeneity in outcome of chronic HBV infection. Most HBV infections are spontaneously resolved in immunocompetent adults, whereas they become chronic in most neonates and infants at a great risk of developing complications such as cirrhosis and hepatocellular carcinoma (HCC). Those with chronic HBV infection may present in one of the four phases of infection: immune tolerance, immune clearance [hepatitis B eantigen (HBeAg)-positive chronic hepatitis B (CHB)], inactive carrier state, and reactivation (HBeAg-negative CHB). Understanding the dynamic nature of chronic HBV infection is crucial in the management of HBV carriers. Long-term monitoring and optimal timing of antiviral therapy for chronic HBV infection help to prevent progression of HBV-related liver disease to its later stage, particularly in patients with higher risk markers of HCC, such as serum DNA concentration, HBeAg status, serum aminotransferase, HBV genotypes, and pre-core or core mutants.展开更多
To make the dynamic assembly reliability analysis more effective for complex machinery of multi-object multi-discipline(MOMD),distributed collaborative extremum response surface method(DCERSM)was proposed based on ext...To make the dynamic assembly reliability analysis more effective for complex machinery of multi-object multi-discipline(MOMD),distributed collaborative extremum response surface method(DCERSM)was proposed based on extremum response surface method(ERSM).Firstly,the basic theories of the ERSM and DCERSM were investigated,and the strengths of DCERSM were proved theoretically.Secondly,the mathematical model of the DCERSM was established based upon extremum response surface function(ERSF).Finally,this model was applied to the reliability analysis of blade-tip radial running clearance(BTRRC)of an aeroengine high pressure turbine(HPT)to verify its advantages.The results show that the DCERSM can not only reshape the possibility of the reliability analysis for the complex turbo machinery,but also greatly improve the computational speed,save the computational time and improve the computational efficiency while keeping the accuracy.Thus,the DCERSM is verified to be feasible and effective in the dynamic assembly reliability(DAR)analysis of complex machinery.Moreover,this method offers an useful insight for designing and optimizing the dynamic reliability of complex machinery.展开更多
To reasonably design the blade-tip radial running clearance(BTRRC) of high pressure turbine and improve the performance and reliability of gas turbine, the multi-object multi-discipline reliability sensitivity analysi...To reasonably design the blade-tip radial running clearance(BTRRC) of high pressure turbine and improve the performance and reliability of gas turbine, the multi-object multi-discipline reliability sensitivity analysis of BTRRC was accomplished from a probabilistic prospective by considering nonlinear material attributes and dynamic loads. Firstly, multiply response surface model(MRSM) was proposed and the mathematical model of this method was established based on quadratic function. Secondly, the BTRRC was decomposed into three sub-components(turbine disk, blade and casing), and then the single response surface functions(SRSFs) of three structures were built in line with the basic idea of MRSM. Thirdly, the response surface function(MRSM) of BTRRC was reshaped by coordinating SRSFs. From the analysis, it is acquired to probabilistic distribution characteristics of input-output variables, failure probabilities of blade-tip clearance under different static blade-tip clearances δ and major factors impacting BTRRC. Considering the reliability and efficiency of gas turbine, δ=1.87 mm is an optimally acceptable option for rational BTRRC. Through the comparison of three analysis methods(Monte Carlo method, traditional response surface method and MRSM), the results show that MRSM has higher accuracy and higher efficiency in reliability sensitivity analysis of BTRRC. These strengths are likely to become more prominent with the increasing times of simulations. The present study offers an effective and promising approach for reliability sensitivity analysis and optimal design of complex dynamic assembly relationship.展开更多
AIM: To investigate hepatitis B surface antigen (HBsAg) levels in patients with HBeAg-positive chronic hepatitis B (CHB) and different immune conditions.
The gas turbine is the main power equipment for naval ship and special civil ship,while the compressor is one of the core structures of the gas turbine.The existing tip clearance could prevent the compressor blade and...The gas turbine is the main power equipment for naval ship and special civil ship,while the compressor is one of the core structures of the gas turbine.The existing tip clearance could prevent the compressor blade and casing collision.Therefore,the flow loss in the tip region caused by the tip clearance will degrade the performance of the compressor.To improve the variable clearance characteristics of the high subsonic compressor cascades,the cascades with tip clearances of 1%,2%and 3%chord length are studied through experimental measurements and numerical calculations.The research results prove that the pressure surface tip winglet can cause a significant improvement effect under most working conditions.If the blade tip clearance size is gradually increasing within a reasonable range,the improvement effect becomes more remarkable,and the optimal tip winglet case changes.When tip clearance is 1%chord length,the PTW1.0 case(the width of the pressure surface tip winglet is 1.0 time of the original tip)reduces the flow loss by 3.09%compared with the NTW case(No Tip Winglet).When tip clearance is 2%chord length,the flow loss of PTW1.5 case(the width of the pressure surface tip winglet is 1.5 times of the original tip)is reduced by 3.46%.When tip clearance is 3%chord length,all alternative tip winglets reduce the total pressure loss,and PTW2.0 case(the width of the pressure surface tip winglet is 2.0 times of the original tip)is the best choice,which has a 6.53%degree of improvement.展开更多
基金the National Natural Science Foundation of China,No.31500650。
文摘BACKGROUND Nucleos(t)ide analog(NA)has shown limited effectiveness against hepatitis B surface antigen(HBsAg)clearance in chronic hepatitis B(CHB)patients.AIM To evaluate the efficacy and safety of add-on peginterferonα-2a(peg-IFNα-2a)to an ongoing NA regimen in CHB patients.METHODS In this observational study,195 CHB patients with HBsAg≤1500 IU/m L,hepatitis B e antigen(HBeAg)-negative(including HBeAg-negative patients or HBeAg-positive patients who achieved HBeAg-negative after antiviral treatment with NA)and hepatitis B virus-deoxyribonucleic acid<1.0×10^2 IU/mL after over 1 year of NA therapy were enrolled between November 2015 and December2018 at the Second Affiliated Hospital of Xi'an Jiaotong University,China.Patients were given the choice between receiving either peg-IFNα-2a add-on therapy to an ongoing NA regimen(add-on group,n=91)or continuous NA monotherapy(monotherapy group,n=104)after being informed of the benefits and risks of the peg-IFNα-2a therapy.Total therapy duration of peg-IFNα-2a was 48 wk.All patients were followed-up to week 72(24 wk after discontinuation of peg-IFNα-2a).The primary endpoint was the proportion of patients with HBsAg clearance at week 72.RESULTS Demographic and baseline characteristics were comparable between the two groups.Intention-to-treatment analysis showed that the HBsAg clearance rate in the add-on group and monotherapy group was 37.4%(34/91)and 1.9%(2/104)at week 72,respectively.The HBsAg seroconversion rate in the add-on group was 29.7%(27/91)at week 72,and no patient in the monotherapy group achieved HBsAg seroconversion at week 72.The HBsAg clearance and seroconversion rates in the add-on group were significantly higher than in the monotherapy group at week 72(P<0.001).Younger patients,lower baseline HBsAg concentration,lower HBsAg concentrations at weeks 12 and 24,greater HBsAg decline from baseline to weeks 12 and 24 and the alanine aminotransferase≥2×upper limit of normal during the first 12 wk of therapy were strong predictors of HBsAg clearance i
基金Supported by Science and Technology Department of Qingdao Government 07-2-1-15-nsh
文摘Hepatitis B virus (HBV) is a common viral pathogen that causes a substantial health burden worldwide. Remarkable progress has been made in our understanding of the natural stages of chronic HBV infection. A dynamic balance between viral replication and host immune response is pivotal to the pathogenesis of liver disease. Knowledge of the HBV genome organization and replication cycle can unravel HBV genotypes and molecular variants, which contribute to the heterogeneity in outcome of chronic HBV infection. Most HBV infections are spontaneously resolved in immunocompetent adults, whereas they become chronic in most neonates and infants at a great risk of developing complications such as cirrhosis and hepatocellular carcinoma (HCC). Those with chronic HBV infection may present in one of the four phases of infection: immune tolerance, immune clearance [hepatitis B eantigen (HBeAg)-positive chronic hepatitis B (CHB)], inactive carrier state, and reactivation (HBeAg-negative CHB). Understanding the dynamic nature of chronic HBV infection is crucial in the management of HBV carriers. Long-term monitoring and optimal timing of antiviral therapy for chronic HBV infection help to prevent progression of HBV-related liver disease to its later stage, particularly in patients with higher risk markers of HCC, such as serum DNA concentration, HBeAg status, serum aminotransferase, HBV genotypes, and pre-core or core mutants.
基金Project(51175017)supported by the National Natural Science Foundation of ChinaProject(YWF-12-RBYJ-008)supported by the Innovation Foundation of Beihang University for PhD Graduates,ChinaProject(20111102110011)supported by the Research Fund for the Doctoral Program of Higher Education of China
文摘To make the dynamic assembly reliability analysis more effective for complex machinery of multi-object multi-discipline(MOMD),distributed collaborative extremum response surface method(DCERSM)was proposed based on extremum response surface method(ERSM).Firstly,the basic theories of the ERSM and DCERSM were investigated,and the strengths of DCERSM were proved theoretically.Secondly,the mathematical model of the DCERSM was established based upon extremum response surface function(ERSF).Finally,this model was applied to the reliability analysis of blade-tip radial running clearance(BTRRC)of an aeroengine high pressure turbine(HPT)to verify its advantages.The results show that the DCERSM can not only reshape the possibility of the reliability analysis for the complex turbo machinery,but also greatly improve the computational speed,save the computational time and improve the computational efficiency while keeping the accuracy.Thus,the DCERSM is verified to be feasible and effective in the dynamic assembly reliability(DAR)analysis of complex machinery.Moreover,this method offers an useful insight for designing and optimizing the dynamic reliability of complex machinery.
基金Projects(51175017,51245027)supported by the National Natural Science Foundation of China
文摘To reasonably design the blade-tip radial running clearance(BTRRC) of high pressure turbine and improve the performance and reliability of gas turbine, the multi-object multi-discipline reliability sensitivity analysis of BTRRC was accomplished from a probabilistic prospective by considering nonlinear material attributes and dynamic loads. Firstly, multiply response surface model(MRSM) was proposed and the mathematical model of this method was established based on quadratic function. Secondly, the BTRRC was decomposed into three sub-components(turbine disk, blade and casing), and then the single response surface functions(SRSFs) of three structures were built in line with the basic idea of MRSM. Thirdly, the response surface function(MRSM) of BTRRC was reshaped by coordinating SRSFs. From the analysis, it is acquired to probabilistic distribution characteristics of input-output variables, failure probabilities of blade-tip clearance under different static blade-tip clearances δ and major factors impacting BTRRC. Considering the reliability and efficiency of gas turbine, δ=1.87 mm is an optimally acceptable option for rational BTRRC. Through the comparison of three analysis methods(Monte Carlo method, traditional response surface method and MRSM), the results show that MRSM has higher accuracy and higher efficiency in reliability sensitivity analysis of BTRRC. These strengths are likely to become more prominent with the increasing times of simulations. The present study offers an effective and promising approach for reliability sensitivity analysis and optimal design of complex dynamic assembly relationship.
基金Supported by China National Science and Technology Major Project,No.2012ZX10002004 and No.2013ZX10002001the Chinese High Tech Research and Development(863)Program,No.2011AA020104Zhejiang CTM Science and Technology Project,No.2011ZB061
文摘AIM: To investigate hepatitis B surface antigen (HBsAg) levels in patients with HBeAg-positive chronic hepatitis B (CHB) and different immune conditions.
基金supported by the National Natural Science Foundation of China(Grant Nos.51906134 and 51436002)。
文摘The gas turbine is the main power equipment for naval ship and special civil ship,while the compressor is one of the core structures of the gas turbine.The existing tip clearance could prevent the compressor blade and casing collision.Therefore,the flow loss in the tip region caused by the tip clearance will degrade the performance of the compressor.To improve the variable clearance characteristics of the high subsonic compressor cascades,the cascades with tip clearances of 1%,2%and 3%chord length are studied through experimental measurements and numerical calculations.The research results prove that the pressure surface tip winglet can cause a significant improvement effect under most working conditions.If the blade tip clearance size is gradually increasing within a reasonable range,the improvement effect becomes more remarkable,and the optimal tip winglet case changes.When tip clearance is 1%chord length,the PTW1.0 case(the width of the pressure surface tip winglet is 1.0 time of the original tip)reduces the flow loss by 3.09%compared with the NTW case(No Tip Winglet).When tip clearance is 2%chord length,the flow loss of PTW1.5 case(the width of the pressure surface tip winglet is 1.5 times of the original tip)is reduced by 3.46%.When tip clearance is 3%chord length,all alternative tip winglets reduce the total pressure loss,and PTW2.0 case(the width of the pressure surface tip winglet is 2.0 times of the original tip)is the best choice,which has a 6.53%degree of improvement.
