A miniaturized circulator using barium ferrite films with a coplanar waveguide （CPW） structure is designed and optimized by high frequency electromagnetic field simulations based on finite element methods. The best ...A miniaturized circulator using barium ferrite films with a coplanar waveguide （CPW） structure is designed and optimized by high frequency electromagnetic field simulations based on finite element methods. The best circulation performance of the film circulator based on 10 pm thick barium ferrite thin films is obtained with an insertion loss of 0.13 dB and an isolation of 22.89 dB around 36.9 GHz. The microwave characteristics of film circulators with CPW and CPW with ground （CPWG） structures have been compared. The influences of the gap between the ground and the signal line, and the ferromagnetic resonance line width on the microwave properties are also studied.展开更多
Strontium ferrites with different Bi2O3 content are prepared by the solid phase method, and their magnetic properties are investigated primarily. The Bi2O3 additive and sintering temperature separately exhibit a stron...Strontium ferrites with different Bi2O3 content are prepared by the solid phase method, and their magnetic properties are investigated primarily. The Bi2O3 additive and sintering temperature separately exhibit a strong effect on the sintering density, crystal structure, and magnetic properties of the ferrites. As to the ferrites with 3 wt% Bi2O3, the relatively high sintering density ρs, saturation magnetization Ms, and intrinsic coercivity HCi can be obtained at a low sintering temperature of 900℃ even much lower. Furthermore, the effective magnetic anisotropy constant Keff and magnetic anisotropy field Ha of the ferrites are calculated from the magnetization curve by the law of approach to saturation. It is suggested that the low-temperature sintered SrFe12O19 ferrites with Ms of 285.6 kA/m and Ha of 1564.6 kA/m possess a significant potentiality for applying in the self-biased low-temperature co-fired ceramics circulators from 34 to 40GHz.展开更多
Nonreciprocal elements,such as isolators and circulators,play an important role in classical and quantum information processing.Recently,strong nonreciprocal effects have been experimentally demonstrated in cavity opt...Nonreciprocal elements,such as isolators and circulators,play an important role in classical and quantum information processing.Recently,strong nonreciprocal effects have been experimentally demonstrated in cavity optomechanical systems.In these approaches,the bandwidth of the nonreciprocal photon transmission is limited by the mechanical resonator linewidth,which is arguably much smaller than the linewidths of the cavity modes in most electromechanical or optomechanical devices.In this work,we demonstrate broadband nonreciprocal photon transmission in the reversed-dissipation regime,where the mechanical mode with a large decay rate can be adiabatically eliminated while mediating anti-PT-symmetric dissipative coupling with two kinds of phase factors.Adjusting the relative phases allows the observation of periodic Riemann-sheet structures with distributed exceptional points(Eps).At the Eps,destructive quantum interference breaks both theT-andP-inversion symmetry,resulting in unidirectional and chiral photon transmissions.In the reversed-dissipation regime,the nonreciprocal bandwidth is no longer limited by the mechanical mode linewidth but is improved to the linewidth of the cavity resonance.Furthermore,we find that the direction of the unidirectional and chiral energy transfer could be reversed by changing the parity of the Eps.Extending non-Hermitian couplings to a three-cavity model,the broken anti-PT-symmetry allows us to observe high-order Eps,at which a parity-dependent chiral circulator is demonstrated.The driving-phase controlled periodical Riemann sheets allow observation of the parity-dependent unidirectional and chiral energy transfer and thus provide a useful cell for building up nonreciprocal array and realizing topological,e.g.,isolators,circulators,or amplifiers.展开更多
为了与低温共烧陶瓷(LTCC)技术兼容,采用热压烧结工艺在870℃制备了添加不同Bi_2O_3含量的SrFe_(12)O_(19)铁氧体材料,着重研究了材料的晶相组成、烧结密度、气孔率和磁性能等低温烧结特性。研究结果表明,材料在870℃烧结时,Bi_2O_3的...为了与低温共烧陶瓷(LTCC)技术兼容,采用热压烧结工艺在870℃制备了添加不同Bi_2O_3含量的SrFe_(12)O_(19)铁氧体材料,着重研究了材料的晶相组成、烧结密度、气孔率和磁性能等低温烧结特性。研究结果表明,材料在870℃烧结时,Bi_2O_3的添加促进了SrFe_(12)O_(19)晶相结构的形成,提高了材料的烧结致密度和磁性能。当Bi_2O_3的添加量(质量分数)为2%~4%,材料可以获得致密的结构,烧结密度达到4.65 g·cm^(-3)以上,气孔率低于10%,材料的饱和磁化强度Ms和内禀矫顽力Hci较高,分别达到252.4 k A·m^(-1)和312.9k A·m^(-1)以上。此外,基于SrFe_(12)O_(19)材料的低温烧结特性讨论了该材料在微波LTCC环行器当中的应用。展开更多
Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently,m RNAs and micro RNAs（mi RNAs） h...Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently,m RNAs and micro RNAs（mi RNAs） have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal mi RNAs, since the mi RNA profiles of exosomes may differ from those of the parent cells. Exosomal mi RNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal mi RNAs, and briefly describe how exosomes and their mi RNAs function in recipient cells.Finally, we will discuss the potential applications of these mi RNA-containing vesicles in clinical settings.展开更多
Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the tr...Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC.展开更多
基金supported by the National Basic Research Program of China under Grant No. 61363Z06.1
文摘A miniaturized circulator using barium ferrite films with a coplanar waveguide （CPW） structure is designed and optimized by high frequency electromagnetic field simulations based on finite element methods. The best circulation performance of the film circulator based on 10 pm thick barium ferrite thin films is obtained with an insertion loss of 0.13 dB and an isolation of 22.89 dB around 36.9 GHz. The microwave characteristics of film circulators with CPW and CPW with ground （CPWG） structures have been compared. The influences of the gap between the ground and the signal line, and the ferromagnetic resonance line width on the microwave properties are also studied.
基金Supported by the Fundamental Research Funds for the Central Universities(ZYGX2010J039)the Defense Pre-Research Foundation of China(9140A12020311DZ0202)the Program for NCET(NCET-12-0099)
基金Supported by the Scientific Research Foundation of Education Office of Sichuan Province under Grant No 13Z198the Young and Middle-aged Academic Leaders of Scientific Research Funds of Chengdu University of Information Technology under Grant No J201222
文摘Strontium ferrites with different Bi2O3 content are prepared by the solid phase method, and their magnetic properties are investigated primarily. The Bi2O3 additive and sintering temperature separately exhibit a strong effect on the sintering density, crystal structure, and magnetic properties of the ferrites. As to the ferrites with 3 wt% Bi2O3, the relatively high sintering density ρs, saturation magnetization Ms, and intrinsic coercivity HCi can be obtained at a low sintering temperature of 900℃ even much lower. Furthermore, the effective magnetic anisotropy constant Keff and magnetic anisotropy field Ha of the ferrites are calculated from the magnetization curve by the law of approach to saturation. It is suggested that the low-temperature sintered SrFe12O19 ferrites with Ms of 285.6 kA/m and Ha of 1564.6 kA/m possess a significant potentiality for applying in the self-biased low-temperature co-fired ceramics circulators from 34 to 40GHz.
基金supported by the China Postdoctoral Science Foundation under Grant No.2021M700442Y.L.Liu acknowledges the support of the Natural Science Foundation of China(NSFC)under Grant No.12004044+5 种基金H.F.Y acknowledges the support from the NSFC of China(11890704)the NSF of Beijing(Z190012)T.F.Li acknowledges the support of the Development Program of China(2016YFA0301200)the National Natural Science Foundation of China(62074091,and U1930402)the Science Challenge Project(TZ2018003)Tsinghua University Initiative Scientific Research Program.
文摘Nonreciprocal elements,such as isolators and circulators,play an important role in classical and quantum information processing.Recently,strong nonreciprocal effects have been experimentally demonstrated in cavity optomechanical systems.In these approaches,the bandwidth of the nonreciprocal photon transmission is limited by the mechanical resonator linewidth,which is arguably much smaller than the linewidths of the cavity modes in most electromechanical or optomechanical devices.In this work,we demonstrate broadband nonreciprocal photon transmission in the reversed-dissipation regime,where the mechanical mode with a large decay rate can be adiabatically eliminated while mediating anti-PT-symmetric dissipative coupling with two kinds of phase factors.Adjusting the relative phases allows the observation of periodic Riemann-sheet structures with distributed exceptional points(Eps).At the Eps,destructive quantum interference breaks both theT-andP-inversion symmetry,resulting in unidirectional and chiral photon transmissions.In the reversed-dissipation regime,the nonreciprocal bandwidth is no longer limited by the mechanical mode linewidth but is improved to the linewidth of the cavity resonance.Furthermore,we find that the direction of the unidirectional and chiral energy transfer could be reversed by changing the parity of the Eps.Extending non-Hermitian couplings to a three-cavity model,the broken anti-PT-symmetry allows us to observe high-order Eps,at which a parity-dependent chiral circulator is demonstrated.The driving-phase controlled periodical Riemann sheets allow observation of the parity-dependent unidirectional and chiral energy transfer and thus provide a useful cell for building up nonreciprocal array and realizing topological,e.g.,isolators,circulators,or amplifiers.
基金The Scientific Research Foundation of Education Office of Sichuan Province(13Z198)The Young and Middle-aged Academic Leaders of Scientific Research Funds of Chengdu University of Information Technology(J201222)
文摘为了与低温共烧陶瓷(LTCC)技术兼容,采用热压烧结工艺在870℃制备了添加不同Bi_2O_3含量的SrFe_(12)O_(19)铁氧体材料,着重研究了材料的晶相组成、烧结密度、气孔率和磁性能等低温烧结特性。研究结果表明,材料在870℃烧结时,Bi_2O_3的添加促进了SrFe_(12)O_(19)晶相结构的形成,提高了材料的烧结致密度和磁性能。当Bi_2O_3的添加量(质量分数)为2%~4%,材料可以获得致密的结构,烧结密度达到4.65 g·cm^(-3)以上,气孔率低于10%,材料的饱和磁化强度Ms和内禀矫顽力Hci较高,分别达到252.4 k A·m^(-1)和312.9k A·m^(-1)以上。此外,基于SrFe_(12)O_(19)材料的低温烧结特性讨论了该材料在微波LTCC环行器当中的应用。
基金supported by the Projects of International Cooperation and Exchanges from the National Natural Science Foundation of China(Grant No.31161120358)the National Basic Research Program from the Ministry of Science and Technology of China(973 program+3 种基金Grant Nos20111CB510106 and 2015CB910603)the Open Project of State Key Laboratory of Biomembrane and Membrane Biotechnologythe Scientific Research Foundation for Returned Scholars from the Ministry of Education of ChinaML was supported by National Natural Science Foundation of China(Grant No.31400741)
文摘Exosomes are 40–100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently,m RNAs and micro RNAs（mi RNAs） have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal mi RNAs, since the mi RNA profiles of exosomes may differ from those of the parent cells. Exosomal mi RNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal mi RNAs, and briefly describe how exosomes and their mi RNAs function in recipient cells.Finally, we will discuss the potential applications of these mi RNA-containing vesicles in clinical settings.
基金Supported by a grant of the Romanian National Authority for Scientific Research and Innovation,CNCS-UEFISCDI,No.PN-Ⅲ-P4-ID-PCCF2016-0158(contract PCCF17/2018)within PNCDI Ⅲ
文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC.
