期刊文献+
共找到7篇文章
< 1 >
每页显示 20 50 100
Primary sclerosing cholangitis:A review and update 被引量:5
1
作者 James H.Tabibian Christopher L.Bowlus 《Liver Research》 2017年第4期221-230,共10页
Primary sclerosing cholangitis(PSC)is a rare,chronic,cholestatic liver disease of uncertain etiology characterized biochemically by cholestasis and histologically and cholangiographically by fibroobliterative inflamma... Primary sclerosing cholangitis(PSC)is a rare,chronic,cholestatic liver disease of uncertain etiology characterized biochemically by cholestasis and histologically and cholangiographically by fibroobliterative inflammation of the bile ducts.In a clinically significant proportion of patients,PSC progresses to cirrhosis,end-stage liver disease,and/or hepatobiliary cancer,though the disease course can be highly variable.Despite clinical trials of numerous pharmacotherapies over several decades,safe and effective medical therapy remains to be established.Liver transplantation is an option for select patients with severe complications of PSC,and its outcomes are generally favorable.Periodic surveillance testing for pre-as well as post-transplant patients is a cornerstone of preventive care and health maintenance.Here we provide an overview of PSC,including its epidemiology,etiopathogenesis,clinical features,associated disorders,surveillance,and emerging potential therapies. 展开更多
关键词 Bile duct diseases Primary sclerosing cholangitis(psc) CHOLESTASIS cholangIOCARCINOMA Magnetic resonance imaging cholangiography Natural history
原文传递
Mucosa-associated microbiota alterations in primary sclerosing cholangitis(PSC)before and after liver transplantation-who is calling the shots?
2
作者 Münevver Demir Michael Sigal 《Hepatobiliary Surgery and Nutrition》 SCIE 2023年第5期795-797,共3页
Primary sclerosing cholangitis(PSC)is an immune-related chronic cholangiopathy associated with high rates of progression to liver cirrhosis and the need for liver transplantation.Since PSC is frequently associated wit... Primary sclerosing cholangitis(PSC)is an immune-related chronic cholangiopathy associated with high rates of progression to liver cirrhosis and the need for liver transplantation.Since PSC is frequently associated with inflammatory bowel disease(IBD),several studies have investigated the role of the gut-liver axis in PSC and emerging evidence indicates that gut and bile microbiota are associated with the onset and progression of PSC[reviewed in(1)]. 展开更多
关键词 Primary sclerosing cholangitis(psc) liver transplantation KLEBSIELLA MICROBIOTA mucosal microbiota
原文传递
Biliary endoscopy in the management of primary sclerosing cholangitis and its complications 被引量:3
3
作者 Brian M.Fung James H.Tabibian 《Liver Research》 2019年第2期106-117,共12页
Primary sclerosing cholangitis(PSC)is a chronic,idiopathic,cholestatic liver disease characterized by inflammation and fibrosis of the intrahepatic and/or extrahepatic bile ducts.It can affect individuals of all age g... Primary sclerosing cholangitis(PSC)is a chronic,idiopathic,cholestatic liver disease characterized by inflammation and fibrosis of the intrahepatic and/or extrahepatic bile ducts.It can affect individuals of all age groups and gender,has no established pharmacotherapy,and is associated with a variety of neoplastic(e.g.cholangiocarcinoma)and non-neoplastic(e.g.dominant strictures)hepatobiliary complications.Given these considerations,endoscopy plays a major role in the care of patients with PSC.In this review,we discuss and provide updates regarding endoscopic considerations in the management of hepatobiliary manifestations and complications of PSC.Where evidence is limited,we suggest pragmatic approaches based on currently available data and expert opinion. 展开更多
关键词 Primary sclerosing cholangitis(psc) Biliary tract disease Balloon dilation cholangIOSCOPY Dominant stricture cholangiocarcinoma(CCA) Endoscopic retrograde cholangiopancreatography(ERCP)
原文传递
Preventative care in cholestatic liver disease: Pearls for the specialist and subspecialist
4
作者 Adnan Malik Ani A.Kardashian +2 位作者 Kais Zakharia Christopher L.Bowlus James H.Tabibian 《Liver Research》 2019年第2期118-127,共10页
Cholestatic liver diseases(CLDs)encompass a variety of disorders of abnormal bile formation and/or flow.CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associate... Cholestatic liver diseases(CLDs)encompass a variety of disorders of abnormal bile formation and/or flow.CLDs often lead to progressive hepatic insult and injury and following the development of cirrhosis and associated complications.Many such complications are clinically silent until they manifest with severe sequelae,including but not limited to life-altering symptoms,metabolic disturbances,cirrhosis,and hepatobiliary diseases as well as other malignancies.Primary sclerosing cholangitis(PSC)and primary biliary cholangitis(PBC)are the most common CLDs,and both relate to mutual as well as unique complications.This review provides an overview of PSC and PBC,with a focus on preventive measures aimed to reduce the incidence and severity of disease-related complications. 展开更多
关键词 Biliary tract diseases Primary sclerosing cholangitis(psc) Primary biliary cholangitis(PBC) Cirrhosis Inflammatory bowel disease(IBD) Metabolic bone disease PRURITUS PROPHYLAXIS
原文传递
中医药治疗自身免疫性肝病研究进展 被引量:5
5
作者 黄鹏 邱华 李家焕 《河南中医》 2020年第1期134-139,共6页
自身免疫性肝病(autoimmune liver diseases,AILD)的发生发展及疾病演变规律与"湿""瘀""毒""虚"密切相关,治疗上多采用活血化瘀、疏肝理气、清热解毒、健脾益肾之法。临床研究包括对自身免疫... 自身免疫性肝病(autoimmune liver diseases,AILD)的发生发展及疾病演变规律与"湿""瘀""毒""虚"密切相关,治疗上多采用活血化瘀、疏肝理气、清热解毒、健脾益肾之法。临床研究包括对自身免疫性肝炎、原发性胆汁性胆管炎和原发性硬化性胆管炎的辨证论治、自拟方及中成药治疗。实验研究分为单味药及有效成分和中药复方制剂。中医药治疗AILD存在如药物起效慢,服用时间长,患者难以长期坚持等。故中医药治疗AILD今后应在以下5个方面加强研究:①在临床研究方面,有必要进行多中心、大样本、随机对照前瞻性的研究;②在基础理论方面,需对AILD的"湿""瘀""毒""虚"四者与阴阳之间的关系进行详细的论述及分析;③在药学研究方面,应用现代生物学、药学技术筛选及优化具有高活性的保肝护肝及调节免疫的单体化合物,以期研发出具有原创性的中药新药;④在学科技术方面,需加强与遗传学、分子生物学、细胞生物学等多学科相互交叉协作,为进一步开发出更有效的药物提供多个学科基础;⑤在诊疗体系方面,应制定出符合AILD临床特点的统一的中医分型、治则治法、处方用药及疗效评价标准的方案,从而建立一套规范的中医药诊治AILD体系。 展开更多
关键词 自身免疫性肝病 自身免疫性肝炎 原发性胆汁性胆管炎 原发性硬化性胆管炎
下载PDF
原发性硬化性胆管炎并发自身免疫性胰腺炎1例 被引量:2
6
作者 徐进 杜勇 成健康 《胃肠病学和肝病学杂志》 CAS 2013年第4期387-388,共2页
自身免疫性胰腺炎(AIP)是由自身免疫机制介导的,以淋巴细胞、浆细胞浸润伴有胰腺纤维化及功能障碍为特征的特殊的慢性胰腺炎,可累及胆管、涎腺、肾等胰外器官,偶尔合并其他自身免疫性疾病如炎症性肠病(IBD)、原发性硬化性胆管炎(PSC)、... 自身免疫性胰腺炎(AIP)是由自身免疫机制介导的,以淋巴细胞、浆细胞浸润伴有胰腺纤维化及功能障碍为特征的特殊的慢性胰腺炎,可累及胆管、涎腺、肾等胰外器官,偶尔合并其他自身免疫性疾病如炎症性肠病(IBD)、原发性硬化性胆管炎(PSC)、干燥综合征等,该病治疗一般予以激素等对症支持治疗可明显好转。 展开更多
关键词 原发性硬化性胆管炎 自身免疫性胰腺炎 炎症性肠病 糖皮质激素 熊去氧胆
下载PDF
原发性硬化性胆管炎的临床和影像学特征分析
7
作者 于建安 贾翠宇 +4 位作者 武志岗 赵大伟 冯骥良 宋文艳 李宏军 《北京医学》 CAS 2022年第10期897-901,906,共6页
目的探讨原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)的临床及影像学特点,为PSC诊断和预后提供科学依据。方法选取2013年5月至2021年12月首都医科大学附属北京佑安医院诊断为PSC的40例患者,对其临床资料、实验室检查、影... 目的探讨原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)的临床及影像学特点,为PSC诊断和预后提供科学依据。方法选取2013年5月至2021年12月首都医科大学附属北京佑安医院诊断为PSC的40例患者,对其临床资料、实验室检查、影像学表现进行回顾性分析。结果40例患者男女比例为1.2∶1,平均年龄为52.4岁,临床症状以腹痛和腹胀、疲乏为主,合并炎性肠病5例,糖尿病7例。肝功能异常39例(97.5%),其中ALT升高21例,AST升高34例,T-BIL升高32例,GGT升高35例,碱性磷酸酶(alkaline phosphatase,ALP)升高34例,CA19-9升高21例。抗线粒体抗体(anti-mitochondrial antibody,AMA)阳性2例(5.0%),抗核抗体(antinuclear antibody,ANA)阳性25例(62.5%),二者均阳性3例(7.5%)。磁共振胰胆管造影(magnetic resonance cholangiopancreatography,MRCP)及内镜逆行胰胆管造影(endoscopic retrograde cholangiopancreatography,ERCP)显示,肝左叶、右叶肝内胆管均累及且呈串珠状表现36例(90.0%),单独肝右叶肝内胆管累及2例(5.0%),单独肝左叶肝内胆管累及1例(2.5%),肝内外胆管无扩张1例(2.5%);肝内外胆管均异常9例(22.5%)。CT增强及MRI表现以肝叶为基础的结节样增生15例(37.5%),包括弥漫性增大2例、尾状叶增大7例、尾状叶+右叶增大3例、尾状叶+左叶增大1例及单独左叶增大2例。其他影像学表现包括肝硬化28例(70.0%),肝内不均质强化14例(35.0%),胆囊壁增厚并明显强化15例(37.5%),胆囊切除8例(20.0%)等。结论PSC缺乏特异性的临床表现和实验室指标,当影像学检查出现肝内或肝内外胆管串珠状表现及肝叶异常比例增生时,应高度提示PSC的可能。 展开更多
关键词 原发性硬化性胆管炎 自身免疫性肝炎 影像学特点 磁共振胰胆管造影 内镜逆行胰胆管造影 CT MRI
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部