Macrolide antibiotics have been widely used in clinic due to their good antibacterial effects and high safety, but the drug-resistant bacteria appear constantly. To solve the problem of drug resistance in pathogens, s...Macrolide antibiotics have been widely used in clinic due to their good antibacterial effects and high safety, but the drug-resistant bacteria appear constantly. To solve the problem of drug resistance in pathogens, scholars obtain the third generation of macrolide antibiotics, ketolide antibiotics, which are developed by modifying the structure of macrolide antibiotics, thereby efficiently solving the problem. Ketolide antibiotics are a type of erythromycin derivatives with macrolide structure, and the typical drugs mainly include telithromycin, cethromycin and solithromycin, etc . This paper briefly introduced the recent progress of ketolide antibiotics, with an attempt to provide help to the research and development of new macrolide antibiotics.展开更多
Advanced Life Sciences（ALS）公司的cethromycin是一天给药一次的口服抗生素，已对超过5，000例病人进行过试验，发现它对范围广泛的呼吸道病原体、社会获得性肺炎（CAP）和吸入炭疽有高度活性。它也能克服对青霉素和大环内酯类的抗...Advanced Life Sciences（ALS）公司的cethromycin是一天给药一次的口服抗生素，已对超过5，000例病人进行过试验，发现它对范围广泛的呼吸道病原体、社会获得性肺炎（CAP）和吸入炭疽有高度活性。它也能克服对青霉素和大环内酯类的抗药性，对氟喹诺酮抗药性肺炎链球菌有活性并不会引起侧枝损伤，且在体外对社区获得性MRSA的优势株有活性。一项比较cethromycin和目前市售治疗药Abbott公司的Biaxin（clarithromycin，展开更多
抗感染药物咨询委员会
6月2日，委员会将讨论Advanced Life Sciences公司的cethromycin口服片剂的新药申请（NDA22—398），该药用于治疗轻到中度成年社区获得性肺炎门诊患者。6月3日，委员会将讨论有关开发结核病（包括耐药性结核）...抗感染药物咨询委员会
6月2日，委员会将讨论Advanced Life Sciences公司的cethromycin口服片剂的新药申请（NDA22—398），该药用于治疗轻到中度成年社区获得性肺炎门诊患者。6月3日，委员会将讨论有关开发结核病（包括耐药性结核）治疗药的问题，讨论范围包括诊断、治疗期、研究设计（如试验终点及随访期）及安全性问题。展开更多
基金Supported by National Sci-tech Support Plant during Twelfth Five-Year Plan(2015BAD1101)Earmarked Fund for China Agriculture Research System(CAR-38)~~
文摘Macrolide antibiotics have been widely used in clinic due to their good antibacterial effects and high safety, but the drug-resistant bacteria appear constantly. To solve the problem of drug resistance in pathogens, scholars obtain the third generation of macrolide antibiotics, ketolide antibiotics, which are developed by modifying the structure of macrolide antibiotics, thereby efficiently solving the problem. Ketolide antibiotics are a type of erythromycin derivatives with macrolide structure, and the typical drugs mainly include telithromycin, cethromycin and solithromycin, etc . This paper briefly introduced the recent progress of ketolide antibiotics, with an attempt to provide help to the research and development of new macrolide antibiotics.
文摘Advanced Life Sciences（ALS）公司的cethromycin是一天给药一次的口服抗生素，已对超过5，000例病人进行过试验，发现它对范围广泛的呼吸道病原体、社会获得性肺炎（CAP）和吸入炭疽有高度活性。它也能克服对青霉素和大环内酯类的抗药性，对氟喹诺酮抗药性肺炎链球菌有活性并不会引起侧枝损伤，且在体外对社区获得性MRSA的优势株有活性。一项比较cethromycin和目前市售治疗药Abbott公司的Biaxin（clarithromycin，
文摘抗感染药物咨询委员会
6月2日，委员会将讨论Advanced Life Sciences公司的cethromycin口服片剂的新药申请（NDA22—398），该药用于治疗轻到中度成年社区获得性肺炎门诊患者。6月3日，委员会将讨论有关开发结核病（包括耐药性结核）治疗药的问题，讨论范围包括诊断、治疗期、研究设计（如试验终点及随访期）及安全性问题。
