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Non-invasive Prenatal Gene Diagnosis: Progress through Cell-free Fetal DNA and RNA in Maternal Plasma and Urine
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作者 GUO Xun-yang, GUO Yi-bin ( Department of Medical Genetics, Zhongshan School of Medicine, SUN Yat-Sen University, Guangzhou 510080, China ) 《中山大学学报(医学科学版)》 CAS CSCD 北大核心 2008年第S2期140-142,共3页
Non-invasive prenatal gene diagnosis has been developed rapidly in the recent years, and numerous medical researchers are focusing on it. Such techniques could not only achieve prenatal diagnosis accurately, but also ... Non-invasive prenatal gene diagnosis has been developed rapidly in the recent years, and numerous medical researchers are focusing on it. Such techniques could not only achieve prenatal diagnosis accurately, but also prevent tangential illness in fetuses and thus, reduce the incidence of diseases. Moreover, it is non-invasive prenatal gene diagnosis that prevents potential threaten and danger to both mothers and fetuses. Therefore, it is welcomed by clinical gynecologist and obstetrian, researchers of medical genetics, and especially, pregnancies. This review article touches briefly on the advanced development of using cell-free DNA, RNA in maternal plasma and urine for non-invasive prenatal gene diagnosis. 展开更多
关键词 NON-INVASIVE prenatal gene diagnosis cell-free fetal dna and rna dna and rna detection MATErnaL URINE MATErnaL plasma
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应用胎儿细胞游离核酸物质诊断唐氏综合征研究进展
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作者 葛秋林 陈汉平 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2012年第6期470-472,共3页
唐氏综合征(Downsyndrome,DS)是一种人类常见的染色体异常疾病,又名21-三体、先天愚型,主要表现为非进行性智力低下并伴有心脏和其他器官的先天畸形,活产儿发病率约为1/800。随人类产前保健意识及优生优育观念的增强,唐氏综合... 唐氏综合征(Downsyndrome,DS)是一种人类常见的染色体异常疾病,又名21-三体、先天愚型,主要表现为非进行性智力低下并伴有心脏和其他器官的先天畸形,活产儿发病率约为1/800。随人类产前保健意识及优生优育观念的增强,唐氏综合征患儿的出生率虽有所降低,但针对它的传统产前诊断方法(中孕期绒毛膜取样、羊膜腔或脐血穿刺)因有创操作等局限性的存在不能被孕妇普遍接受, 展开更多
关键词 胎儿细胞游离核酸物质 产前诊断 唐氏综合征
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