Generalized case-cohort design has been proved to be a cost-effective way to enhance the efficiency of large epidemiological cohort. In this article, we propose an inference procedure for estimating the unknown parame...Generalized case-cohort design has been proved to be a cost-effective way to enhance the efficiency of large epidemiological cohort. In this article, we propose an inference procedure for estimating the unknown parameters in Cox＇s proportional hazards model in generalized case-cohort design and establish an optimal sample size allocation to achieve the maximum power at a given budget. The finite sample performance of the proposed method is evaluated through simulation studies. The proposed method is applied to a real data set from the National Wilm＇s Tumor Study Group.展开更多
Case-cohort design usually requires the disease rate to be low in large cohort study,although it has been extensively used in practice.However,the disease with high rate is frequently observed in many clinical studies...Case-cohort design usually requires the disease rate to be low in large cohort study,although it has been extensively used in practice.However,the disease with high rate is frequently observed in many clinical studies.Under such circumstances,it is desirable to consider a generalized case-cohort design,where only a fraction of cases are sampled.In this article,we propose the inference procedure for the additive hazards regression under the generalized case-cohort sampling.Asymptotic properties of the proposed estimators for the regression coefcients are established.To demonstrate the efectiveness of the generalized case-cohort sampling,we compare it with simple random sampling in terms of asymptotic relative efciency.Furthermore,we derive the optimal allocation of the subsamples for the proposed design.The fnite sample performance of the proposed method is evaluated through simulation studies.展开更多
Case-cohort sampling is a commonly used and efficient method for studying large cohorts. In many situations, some covariates are easily measured on all cohort subjects, and surrogate measurements of the expensive cova...Case-cohort sampling is a commonly used and efficient method for studying large cohorts. In many situations, some covariates are easily measured on all cohort subjects, and surrogate measurements of the expensive covariates also may be observed. In this paper, to make full use of the covariate data collected outside the case-cohort sample, we propose＇a class of weighted estimators with general time-varying weights for the additive hazards model, and the estimators are shown to be consistent and asymptotically normal. We also identify the estimator within this class that maximizes efficiency, and simulation studies show that the efficiency gains of the proposed estimator over the existing ones can be substantial in practical situations. A real example is provided.展开更多
Case-cohort design is an efficient and economical design to study risk factors for diseases with expensive measurements, especially when the disease rate is low. When several diseases are of interest, multiple case-co...Case-cohort design is an efficient and economical design to study risk factors for diseases with expensive measurements, especially when the disease rate is low. When several diseases are of interest, multiple case-cohort design studies may be conducted using the same subcohort. To study the association between risk factors and each disease occurrence or death, we consider a general additive-multiplicative hazards model for case-cohort designs with multiple disease outcomes. We present an estimation procedure for the regression parameters of the additive-multiplicative hazards model, and show that the proposed estimator is consistent and asymptotically normal. Large sample approximation works well in finite sample studies in simulation. Finally, we apply the proposed method to a real data example for illustration.展开更多
The case-cohort design is widely used in large epidemiological studms and prevention trials for cost reduction. In such a design, covariates are assembled only for a subcohort which is a random subset of the entire co...The case-cohort design is widely used in large epidemiological studms and prevention trials for cost reduction. In such a design, covariates are assembled only for a subcohort which is a random subset of the entire cohort and any additional cases outside the subcohort. In this paper, we discuss the case-cohort analysis with a class of general additive-multiplicative hazard models which includes the commonly used Cox model and additive hazard model as special cases. Two sampling schemes for the subcohort, Bernoulli sampling with arbitrary selection probabilities and stratified simple random sampling with fixed subcohort sizes, are discussed. In each setting, an estimating function is constructed to estimate the regression parameters. The resulting estimator is shown to be consistent and asymptotically normally distributed. The limiting variance-covariance matrix can be consistently estimated by the case-cohort data. A simulation study is conducted to assess the finite sample performances of the proposed method and a real example is provided.展开更多
Case-cohort study designs are widely used to reduce the cost of large cohort studies. When several diseases are of interest, we can use the same subcohort. In this paper, we will study the casecohort design of margina...Case-cohort study designs are widely used to reduce the cost of large cohort studies. When several diseases are of interest, we can use the same subcohort. In this paper, we will study the casecohort design of marginal additive hazards model for multiple outcomes by a more efficient version. Instead of analyzing each disease separately, ignoring the additional exposure measurements collected on subjects with other diseases, we propose a new weighted estimating equation approach to improve the efficiency by utilizing as much information collected as possible. The consistency and asymptotic normality of the resulting estimator are established. Simulation studies are conducted to examine the finite sample performance of the proposed estimator, which confirm the efficiency gains.展开更多
This paper proposes a unified semiparametric method for the additive risk model under general biased sampling. By using the estimating equation approach, we propose both estimators of the regression parameters and non...This paper proposes a unified semiparametric method for the additive risk model under general biased sampling. By using the estimating equation approach, we propose both estimators of the regression parameters and nonparametric function. An advantage is that our approach is still suitable for the lengthbiased data even without the information of the truncation variable. Meanwhile, large sample properties of the proposed estimators are established, including consistency and asymptotic normality. In addition, the finite sample behavior of the proposed methods and the analysis of three groups of real data are given.展开更多
基金Supported in part by the Central Universities under Grant No.31541311216,2042014kf0256the National Natural Science Foundation of China under Grant No.11171263,11301545,61371126 and 11401443
文摘Generalized case-cohort design has been proved to be a cost-effective way to enhance the efficiency of large epidemiological cohort. In this article, we propose an inference procedure for estimating the unknown parameters in Cox＇s proportional hazards model in generalized case-cohort design and establish an optimal sample size allocation to achieve the maximum power at a given budget. The finite sample performance of the proposed method is evaluated through simulation studies. The proposed method is applied to a real data set from the National Wilm＇s Tumor Study Group.
基金supported by the Fundamental Research Fund for the Central Universitiessupported by National Natural Science Foundation of China(Grant No.11301545)supported by National Natural Science Foundation of China(Grant No.11171263)
文摘Case-cohort design usually requires the disease rate to be low in large cohort study,although it has been extensively used in practice.However,the disease with high rate is frequently observed in many clinical studies.Under such circumstances,it is desirable to consider a generalized case-cohort design,where only a fraction of cases are sampled.In this article,we propose the inference procedure for the additive hazards regression under the generalized case-cohort sampling.Asymptotic properties of the proposed estimators for the regression coefcients are established.To demonstrate the efectiveness of the generalized case-cohort sampling,we compare it with simple random sampling in terms of asymptotic relative efciency.Furthermore,we derive the optimal allocation of the subsamples for the proposed design.The fnite sample performance of the proposed method is evaluated through simulation studies.
基金partly supported by the National Natural Science Foundation of China Grants(No.11231010,11171330 and 11101314)Key Laboratory of RCSDS,CAS(No.2008DP173182)and BCMIIS
文摘Case-cohort sampling is a commonly used and efficient method for studying large cohorts. In many situations, some covariates are easily measured on all cohort subjects, and surrogate measurements of the expensive covariates also may be observed. In this paper, to make full use of the covariate data collected outside the case-cohort sample, we propose＇a class of weighted estimators with general time-varying weights for the additive hazards model, and the estimators are shown to be consistent and asymptotically normal. We also identify the estimator within this class that maximizes efficiency, and simulation studies show that the efficiency gains of the proposed estimator over the existing ones can be substantial in practical situations. A real example is provided.
基金partly supported by the Natural Science Research Project of Universities of Anhui Province(No.KJ2016B026)partly supported by the National Natural Science Foundation of China Grants(No.11301355)the Technology Foundation for Selected Overseas Chinese Scholar,Ministry of Personnel of Beijing,China
文摘Case-cohort design is an efficient and economical design to study risk factors for diseases with expensive measurements, especially when the disease rate is low. When several diseases are of interest, multiple case-cohort design studies may be conducted using the same subcohort. To study the association between risk factors and each disease occurrence or death, we consider a general additive-multiplicative hazards model for case-cohort designs with multiple disease outcomes. We present an estimation procedure for the regression parameters of the additive-multiplicative hazards model, and show that the proposed estimator is consistent and asymptotically normal. Large sample approximation works well in finite sample studies in simulation. Finally, we apply the proposed method to a real data example for illustration.
基金supported by the National Natural Science Foundation of China(11101091)the Specialized Research Fund for the Doctoral Program of Higher Education of China(20110071120023)supported by the National Natural Science Foundation of China(10971033)
文摘The case-cohort design is widely used in large epidemiological studms and prevention trials for cost reduction. In such a design, covariates are assembled only for a subcohort which is a random subset of the entire cohort and any additional cases outside the subcohort. In this paper, we discuss the case-cohort analysis with a class of general additive-multiplicative hazard models which includes the commonly used Cox model and additive hazard model as special cases. Two sampling schemes for the subcohort, Bernoulli sampling with arbitrary selection probabilities and stratified simple random sampling with fixed subcohort sizes, are discussed. In each setting, an estimating function is constructed to estimate the regression parameters. The resulting estimator is shown to be consistent and asymptotically normally distributed. The limiting variance-covariance matrix can be consistently estimated by the case-cohort data. A simulation study is conducted to assess the finite sample performances of the proposed method and a real example is provided.
基金supported by Graduate Innovation Foundation of Shanghai University of Finance and Economics,China(Grant No.CXJJ2014-453)the second author is supported by National Natural Science Foundation of China(Grant No.11301355)+1 种基金the Technology Foundation for Selected Overseas Chinese Scholar,Ministry of Personnel of BeijingChina
文摘Case-cohort study designs are widely used to reduce the cost of large cohort studies. When several diseases are of interest, we can use the same subcohort. In this paper, we will study the casecohort design of marginal additive hazards model for multiple outcomes by a more efficient version. Instead of analyzing each disease separately, ignoring the additional exposure measurements collected on subjects with other diseases, we propose a new weighted estimating equation approach to improve the efficiency by utilizing as much information collected as possible. The consistency and asymptotic normality of the resulting estimator are established. Simulation studies are conducted to examine the finite sample performance of the proposed estimator, which confirm the efficiency gains.
基金supported by National Institutes of Health of USA (Grant No. R01 HL113548)National Natural Science Foundation of China (Grant Nos. 11271155, 11371168, J1310022, 11571138, 11501241 and 71271128)+3 种基金Science and Technology Research Program of Education Department in Jilin Province for the 12th Five-Year Plan (Grant No. 440020031139)Jilin Province Natural Science Foundation (Grant Nos. 20130101066JC, 20130522102JH and 20150520053JH)the State Key Program of National Natural Science Foundation of China (Grant No. 71331006)National Center for Mathematics and Interdisciplinary Sciences and Shanghai University of Finance and Economics through Project 211 Phase IV and Shanghai Leading Academic Discipline Project A
文摘This paper proposes a unified semiparametric method for the additive risk model under general biased sampling. By using the estimating equation approach, we propose both estimators of the regression parameters and nonparametric function. An advantage is that our approach is still suitable for the lengthbiased data even without the information of the truncation variable. Meanwhile, large sample properties of the proposed estimators are established, including consistency and asymptotic normality. In addition, the finite sample behavior of the proposed methods and the analysis of three groups of real data are given.
