The presence of dispersion/variability in any process is understood and its careful monitoring may furnish the performance of any process. The interquartile range (IQR) is one of the dispersion measures based on lower...The presence of dispersion/variability in any process is understood and its careful monitoring may furnish the performance of any process. The interquartile range (IQR) is one of the dispersion measures based on lower and upper quartiles. For efficient monitoring of process dispersion, we have proposed auxiliary information based Shewhart-type IQR control charts (namely IQRr and IQRp charts) based on ratio and product estimators of lower and upper quartiles under bivariate normally distributed process. We have developed the control structures of proposed charts and compared their performances with the usual IQR chart in terms of detection ability of shift in process dispersion. For the said purpose power curves are constructed to demonstrate the performance of the three IQR charts under discussion in this article. We have also provided an illustrative example to justify theory and finally closed with concluding remarks.展开更多
In order to enhance the efficiency and specificity of anticancer drug delivery and realize intelligently controlled release,a new multi-functional nanoparticle drug carrier was synthesized.The drug carrier was prepare...In order to enhance the efficiency and specificity of anticancer drug delivery and realize intelligently controlled release,a new multi-functional nanoparticle drug carrier was synthesized.The drug carrier was prepared by functionalizing multi-walled carbon nanotubes(MWCNTs) with polyethylenimines(PEI),fluorescein isothiocyanate(FITC) and glycyrrhizic acid(GL).After detailed characterization,doxorubicin(DOX) was loaded onto the obtained MWCNT composites through π-π stacking interactions.The drug loading capacity of the GL-functionalized material was up to 92%,and the release behavior was significantly pH-sensitive.Release at pH = 5.8(typical of the tumor cell microenvironment) was much more rapid and reached a greater extent than release under normal physiological conditions(pH = 7.4).The modified MWCNTs had high biocompatibility with the liver cancer cell line SMMC-7721,but were able to induce cell death after 24 h incubation if loaded with DOX.Tests with shorter incubation time(2 h) were undertaken to investigate the selectivity of the MWCNT composites,showed that the nanocomposites could specifically target cancer cells.The above results suggest that the functionalized carbon nanotubes-based material has potential applications for targeted delivery and controlled release of anticancer drug.展开更多
文摘The presence of dispersion/variability in any process is understood and its careful monitoring may furnish the performance of any process. The interquartile range (IQR) is one of the dispersion measures based on lower and upper quartiles. For efficient monitoring of process dispersion, we have proposed auxiliary information based Shewhart-type IQR control charts (namely IQRr and IQRp charts) based on ratio and product estimators of lower and upper quartiles under bivariate normally distributed process. We have developed the control structures of proposed charts and compared their performances with the usual IQR chart in terms of detection ability of shift in process dispersion. For the said purpose power curves are constructed to demonstrate the performance of the three IQR charts under discussion in this article. We have also provided an illustrative example to justify theory and finally closed with concluding remarks.
基金Science and Technology Commission of Shanghai Municipality,China(No.16410723700)"111 Project" Biomedical Textile Materials Science and Technology,China(No.B07024)the UK-China Joint Laboratory for Therapeutic Textiles
文摘In order to enhance the efficiency and specificity of anticancer drug delivery and realize intelligently controlled release,a new multi-functional nanoparticle drug carrier was synthesized.The drug carrier was prepared by functionalizing multi-walled carbon nanotubes(MWCNTs) with polyethylenimines(PEI),fluorescein isothiocyanate(FITC) and glycyrrhizic acid(GL).After detailed characterization,doxorubicin(DOX) was loaded onto the obtained MWCNT composites through π-π stacking interactions.The drug loading capacity of the GL-functionalized material was up to 92%,and the release behavior was significantly pH-sensitive.Release at pH = 5.8(typical of the tumor cell microenvironment) was much more rapid and reached a greater extent than release under normal physiological conditions(pH = 7.4).The modified MWCNTs had high biocompatibility with the liver cancer cell line SMMC-7721,but were able to induce cell death after 24 h incubation if loaded with DOX.Tests with shorter incubation time(2 h) were undertaken to investigate the selectivity of the MWCNT composites,showed that the nanocomposites could specifically target cancer cells.The above results suggest that the functionalized carbon nanotubes-based material has potential applications for targeted delivery and controlled release of anticancer drug.
