脆性骨折是糖尿病严重并发症之一,1型和2型糖尿病的脆性骨折风险均会增加。一旦发生骨折,将会严重影响患者的生活质量并带来巨大的经济负担。如何通过生化标志物来评估糖尿病患者的骨折风险,并在疾病早期就采取措施来降低骨折的发生。J ...脆性骨折是糖尿病严重并发症之一,1型和2型糖尿病的脆性骨折风险均会增加。一旦发生骨折,将会严重影响患者的生活质量并带来巨大的经济负担。如何通过生化标志物来评估糖尿病患者的骨折风险,并在疾病早期就采取措施来降低骨折的发生。J Clin Endocrinol Metab杂志近期就这一问题发表了1篇题为《糖尿病患者骨脆性的生化标志物》的综述(Meier C,Eastell R,Pierroz DD,et al.Biochemical Markers of Bone Fragility in Patients With Diabetes[J].J Clin Endocrinol Metab,2023:dgad255)。该文为开放获取文章,本文对其进行了中文编译。该文充分汇总相关文献,就生化标志物、糖尿病药物、糖尿病骨病及脆性骨折之间的相关性进行了总结,为临床诊治提供了科学证据。展开更多
Vertebral involvement in particular is common in sickle cell patients. We report 3 cases of “fish vertebra” fractures in sickle cell patients aged 16, 18, and 24 years old respectively at Laquintinie Hospital, Doual...Vertebral involvement in particular is common in sickle cell patients. We report 3 cases of “fish vertebra” fractures in sickle cell patients aged 16, 18, and 24 years old respectively at Laquintinie Hospital, Douala. When the vertebral fractures were diagnosed, the 3 patients had back pain and kyphosis deformities of the dorsal spine. Treatment with an infusion of biphosphonates (zoledronic acid at a dose of 0.5 mg·per·kg) was offered to all three patients. Two out of three patients received treatment with biphosphonates with a successful outcome. Profound vitamin D deficiency is associated with increased bone remodeling and a history of fractures. In sickle cell anemia, vertebral fractures may also result from bone fragility, which is often overlooked as aseptic osteonecrosis and osteomyelitis, which are very often suspected.展开更多
Background: People with Down syndrome (DS) are a high “at risk” group to develop osteoporosis. Increased morbidity associated with older age, higher prevalence of Alzheimer dementia, hypotonia, hypogonadism, and thy...Background: People with Down syndrome (DS) are a high “at risk” group to develop osteoporosis. Increased morbidity associated with older age, higher prevalence of Alzheimer dementia, hypotonia, hypogonadism, and thyroid disease, are all features of DS and predispose this cohort to musculoskeletal complications. Methods: The Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing (IDS-TILDA) is a representative study of the aging of adults with intellectual disability in Ireland. The sample (N = 753) included 147 people with DS. Data was gathered on participants’ health status, behavioural health, health screenings and activities of daily living. The prevalence of osteoporosis and related risk factors among people with DS was specifically examined. Findings: Of the 147 participants with DS, 9.4% reported a doctor’s diagnosis of osteoporosis;a much lower figure than prevalence of risk factors would suggest. Predisposing factors identified included higher than general population rates of thyroid disease (37.4%), epilepsy (19.3%), sedentary lifestyle (51.7%) and the majority of the females reporting having experienced menopause (61%). Bone health screening was low at (8%) despite the presence of such high levels of risk factors in this population. Conclusion: Given the risk factor findings and the hidden nature of osteoporosis, underreported incidence among people with Down syndrome seems probable. Further investigations and systematic screening are required.展开更多
文摘脆性骨折是糖尿病严重并发症之一,1型和2型糖尿病的脆性骨折风险均会增加。一旦发生骨折,将会严重影响患者的生活质量并带来巨大的经济负担。如何通过生化标志物来评估糖尿病患者的骨折风险,并在疾病早期就采取措施来降低骨折的发生。J Clin Endocrinol Metab杂志近期就这一问题发表了1篇题为《糖尿病患者骨脆性的生化标志物》的综述(Meier C,Eastell R,Pierroz DD,et al.Biochemical Markers of Bone Fragility in Patients With Diabetes[J].J Clin Endocrinol Metab,2023:dgad255)。该文为开放获取文章,本文对其进行了中文编译。该文充分汇总相关文献,就生化标志物、糖尿病药物、糖尿病骨病及脆性骨折之间的相关性进行了总结,为临床诊治提供了科学证据。
文摘Vertebral involvement in particular is common in sickle cell patients. We report 3 cases of “fish vertebra” fractures in sickle cell patients aged 16, 18, and 24 years old respectively at Laquintinie Hospital, Douala. When the vertebral fractures were diagnosed, the 3 patients had back pain and kyphosis deformities of the dorsal spine. Treatment with an infusion of biphosphonates (zoledronic acid at a dose of 0.5 mg·per·kg) was offered to all three patients. Two out of three patients received treatment with biphosphonates with a successful outcome. Profound vitamin D deficiency is associated with increased bone remodeling and a history of fractures. In sickle cell anemia, vertebral fractures may also result from bone fragility, which is often overlooked as aseptic osteonecrosis and osteomyelitis, which are very often suspected.
文摘Background: People with Down syndrome (DS) are a high “at risk” group to develop osteoporosis. Increased morbidity associated with older age, higher prevalence of Alzheimer dementia, hypotonia, hypogonadism, and thyroid disease, are all features of DS and predispose this cohort to musculoskeletal complications. Methods: The Intellectual Disability Supplement to The Irish Longitudinal Study on Ageing (IDS-TILDA) is a representative study of the aging of adults with intellectual disability in Ireland. The sample (N = 753) included 147 people with DS. Data was gathered on participants’ health status, behavioural health, health screenings and activities of daily living. The prevalence of osteoporosis and related risk factors among people with DS was specifically examined. Findings: Of the 147 participants with DS, 9.4% reported a doctor’s diagnosis of osteoporosis;a much lower figure than prevalence of risk factors would suggest. Predisposing factors identified included higher than general population rates of thyroid disease (37.4%), epilepsy (19.3%), sedentary lifestyle (51.7%) and the majority of the females reporting having experienced menopause (61%). Bone health screening was low at (8%) despite the presence of such high levels of risk factors in this population. Conclusion: Given the risk factor findings and the hidden nature of osteoporosis, underreported incidence among people with Down syndrome seems probable. Further investigations and systematic screening are required.
