Alcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver d...Alcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver disease(ALD) is a general term used to refer to this spectrum of alcohol-related liver injuries. Excessive or harmful alcohol use is ranked as one of the top five risk factors for death and disability globally and results in 2.5 million deaths and 69.4 million annual disability adjusted life years. All patients who present with clinical features of hepatitis or chronic liver disease or who have elevated serum elevated transaminase levels should be screened for an alcohol use disorder. The diagnosis of ALD can generally be made based on history, clinical and laboratory findings. However, the diagnosis of ALD can be clinically challenging as there is no single diagnostic test that confirms the diagnosis and patients may not be forthcoming about their degree of alcohol consumption. In addition, clinical findings may be absent or minimal in early ALD characterized by hepatic steatosis. Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean cor-puscular volume, gamma-glutamyltranspeptidase, and IgA to IgG ratio. In unclear cases, the diagnosis can be supported by imaging and liver biopsy. The histological features of ALD can ultimately define the diagnosis according to the typical presence and distribution of hepatic steatosis, inflammation, and Mallory-Denk bodies. Because of the potential reversible nature of ALD with sobriety, regular screening of the general population and early diagnosis are essential.展开更多
A fully-mechanized coal mining (FMCM) technology capable of filling up the goaf with wastes (including solid wastes) is described. Industrial tests have proved that by using this technology not only can waste be re-us...A fully-mechanized coal mining (FMCM) technology capable of filling up the goaf with wastes (including solid wastes) is described. Industrial tests have proved that by using this technology not only can waste be re-used but also coal resources can be exploited with a higher recovery rate without removing buildings located over the working faces. Two special devices, a hydraulic support and a scraper conveyor, run side-by-side on the same working face to simultaneously realize mining and filling. These are described in detail. The tests allow analysis of rock pressure and ground subsidence when backfilling techniques are employed. These values are compared to those from mining without using backfilling techniques, under the same geological conditions. The concept of equivalent mining height is proposed based on theoretical analysis of rock pressure and ground subsidence. The upper limits of the rock pressure and ground subsidence can be estimated in backfilling mining using this concept along with traditional engineering formulae.展开更多
In the present investigation, influence of gaps between multiple floating structures on wave forces is examined. Strong and complicate hydrodynamic interactions between the floating bodies are observed and the numeric...In the present investigation, influence of gaps between multiple floating structures on wave forces is examined. Strong and complicate hydrodynamic interactions between the floating bodies are observed and the numerical computations have proved the existence of the sharp peak force response on each floating body at some special resonant wave numbers. The resonant wave number is also proved to be around kL=nπ(n=1, 2, …, ∞) with a corresponding frequency shift. A small yet finite gap width will also give influence on the resonant frequency and resonant amplitude of the wave forces, but when the distance between two aligned box-shaped floating bodies becomes big enough, the hydrodynamic interaction can be neglected. The strong hydrodynamic interaction feature has its own important practical significance for the design of module structures and the links (connection) in the whole floating body system. Moreover, the importance is closely related to the hydro-elasticity analyses of a multiple box-shaped floating body system, in which local loads may be as important as the integrated loads.展开更多
The behavior of supercavitating and cavitatlng flow around a conical body of revolution with and without ventilation at several angles of attack was studied experimentally. The hydrodynamic forces for a range of cavit...The behavior of supercavitating and cavitatlng flow around a conical body of revolution with and without ventilation at several angles of attack was studied experimentally. The hydrodynamic forces for a range of cavitation number were measured. Comparisons of the appearance and the hydrodynamic forces in condition of cavity with and without ventilation were made over the same range of the cavitation number, and a well agreement was obtained. The changes of the drag were especially studied. The experimental results showed that the drag of the model decreased with the presence of supercavity under the ventilation condition.展开更多
A 3-D time domain method is developed to investigate the gap influence on the wave threes for 3-D multiple floating structures. Special hydrodynamic resonance due to small gaps between multiple floating structures on ...A 3-D time domain method is developed to investigate the gap influence on the wave threes for 3-D multiple floating structures. Special hydrodynamic resonance due to small gaps between multiple floating structures on wave forces is examined. Strong and complicate hydrodynamic interactions between the floating bodies are observed and the numerical computations have proved the existence of the sharp peak force response on each floating body at some special resonant wave numbers. By comparison with the results from the frequency domain technique, the results obtained from the time domain method reveal the similar resonant phenomena and hydrodynamic interaction. The resonant wave numbers are also proved around kL-nπ （n = 1,2 ……∞） with a corresponding frequency shift. The strong hydrodynamic interaction feature is practically significant for the design of module structures and the links （connection） in whole the floating body system.展开更多
BACKGROUND:Airway foreign bodies(AFBs)is an interdisciplinary area between emergency medicine,pediatrics and otolaryngology.It is a life-threatening condition that is not infrequently seen;however,it is poorly covered...BACKGROUND:Airway foreign bodies(AFBs)is an interdisciplinary area between emergency medicine,pediatrics and otolaryngology.It is a life-threatening condition that is not infrequently seen;however,it is poorly covered in medical literature.Accidental aspiration of an element into airways is a widespread clinical scenario among children under 3 years,predominantly males.Moreover,it is the leading cause of infantile deaths and the fourth one among preschool children.DATA RESOURCES:A systemic search was conducted in July 2015 using Pub Med/Pub Med Central Database of The National Center for Biotechnology Information(NCBI)(http://www.ncbi.nlm.nih.gov/).A total of 1 767 articles were identified and most of them were meta-analyses,systematic reviews,and case series.Those thoroughly discussing assessment and management of AFBs were retrieved.RESULTS:AFBs episodes may be either witnessed or missed.Presence of a witness for the inhalation is diagnostic.The later usually present with persistent active cough.A classical triad of paroxysmal cough,wheezing,and dyspnoea/decreased air entry was reported,though many presentations have inconsistent findings.Hence,diagnosis requires high index of clinical suspicion.Flexible fibro-optic bronchoscopy is the gold standard of diagnosis,whereas inhaled objects are best retrieved by rigid bronchoscopes.CONCLUSIONS:Close supervision of pediatrics is the hallmark of prevention.Caregivers should ensure a safe surrounding milieu,including the toys their offspring play with.Immediate complications result from direct obstruction or injury by the inhaled object.Alternatively,prolonged lodging traps air and induces inflammatory response causing atelectesis and pneumonia,respectively.展开更多
Foreign body ingestion encompasses both foreign object ingestion(FOI) and esophageal food impaction(EFI) and represents a common and clinically significant scenario among patients of all ages. The immediate risk to th...Foreign body ingestion encompasses both foreign object ingestion(FOI) and esophageal food impaction(EFI) and represents a common and clinically significant scenario among patients of all ages. The immediate risk to the patient ranges from negligible to life-threatening, depending on the ingested substance,its location, patient fitness, and time to appropriate therapy. This article reviews the FOI and EFI literature and highlights important considerations and implications for pediatric and adult patients as well as their providers. Where published literature is insufficient to provide evidence-based guidance, expert opinion is included to supplement the content of this comprehensive review.展开更多
In previous papers (Wencai, 2002, 2003), the author has analyzed the deep seismic reflection profiles along some of the Mesozoic plutons in East China, and has pointed out that the crustal structures around these intr...In previous papers (Wencai, 2002, 2003), the author has analyzed the deep seismic reflection profiles along some of the Mesozoic plutons in East China, and has pointed out that the crustal structures around these intrusions usually correlate with a special seismic fabric called the seismic multi-arch structure. This paper will continue to show main characteristics of the seismic multi-arch structures and discuss their relationship with mantle-origin magmatism and the lithospheric thinning process. Calibration of seismic reflectors in Chinese continental drilling sites shows that small-scale arch-like reflectors can be generated by fractured eclogites or other plutons, they do not belong to the multi-arch structure specially discussed in the paper. The multi-arch structure is char-acterized by several arch-like reflectors distributed in both the upper and lower crust with granitoid plutons or stocks exposed on the surface, which do not have obvious negative Europium anomalies. Based on the distribution pattern of arch reflectors, the multi-arch magmatic structures can be divided into three main types, namely the simple vertical combination type, the spread arch magmatic struc-ture and the arch-bouquet structure. All of them correlate to mantle-origin magmatism, but occur in different places. The spread arch magmatic structures occur within a Mesozoic/Cenozoic rift zone with very thin and hot lithosphere. The vertical combination type of the multi-arch structures occurred near the rift zones where lithosphere was thin and hot. The arch-bouquet magmatic structures occur far from the rift zones where the lithosphere is not hot. The continental rifting acted as the late episode of the lithospheric thinning process seeing that the rift zones usually coincide with the thinnest parts of the lithosphere in East China. In different locations within the lithospheric thinning areas, mantle-origin magmatic activities have different characteristics, which might generate different types of crustal structures revealed by the dif展开更多
A Time-domain Higher-Order Boundary Element Method（THOBEM） is developed for simulating wave-current interactions with 3-D floating bodies.Through a Taylor series expansion and a perturbation procedure,the model is f...A Time-domain Higher-Order Boundary Element Method（THOBEM） is developed for simulating wave-current interactions with 3-D floating bodies.Through a Taylor series expansion and a perturbation procedure,the model is formulated to the first-order in the wave steepness and in the current velocity,respectively.The boundary value problem is decomposed into a steady double-body flow problem and an unsteady wave problem.Higher-order boundary integral equation methods are then used to solve the proposed problems with a fourth-order Runge-Kutta method for the time marching.An artificial damping layer is adopted to dissipate the scattering waves.Different from the other time-domain numerical models,which are often focused on the wave-current interaction with restrained bodies,the present model deals with a floating hemisphere.The numerical results of wave forces,wave run-up and body response are all in a close agreement with those obtained by frequency-domain methods.The proposed numerical model is further applied to investigate wave-current interactions with a floating body of complicated geometry.In this work,the regular and focused wave combined with current interacting with a truss-spar platform is investigated.展开更多
Domain of unknown function 1644 （DUF1644） is a highly conserved amino acid sequence motif present only in plants. Analysis of expression data of the family of DUF1644- containing genes indicated that they may regula...Domain of unknown function 1644 （DUF1644） is a highly conserved amino acid sequence motif present only in plants. Analysis of expression data of the family of DUF1644- containing genes indicated that they may regulate responses to abiotic stress in rice. Here we present our discovery of the role of Os.SIDP366, a member of the DUF1644 gene family, in response to drought and salinity stresses in rice. Transgenic rice plants overexpressing OsSIDP366 showed enhanced drought and salinity tolerance and reduced water loss as compared to that in the control, whereas plants with downregulated OsSIDP366 expression levels using RNA interference （RNAi） were more sensitive to salinity and drought treatments. The sensitivity to abscisic acid （ABA） treatment was not changed in OsStDP366-overexpressing plants, and OsSIDP366 expression was not affected in ABA- deficient mutants. Subcellular localization analysis revealed that OsSIDP366 is presented in the cytoplasmic foci that colocalized with protein markers for both processing bodies （PBs） and stress granules （SGs） in rice protoplasts. Digital gene expression （DGE） profile analysis indicated that stress-related genes such as SNACl, OsHAK5 and PRs were upregulated in OsSIDP366-overexpressing plants. These results suggest that OsSIDP366 may function as a regulator of the PBs/SGs and positively regulate salt and drought resistance in rice.展开更多
Infrastructure mega-project(IMP) innovation is a complex process characterized by highly diverse innovators, a dynamic life-cycle, and stickiness of innovation knowledge. The IMP's innovation network can be easily...Infrastructure mega-project(IMP) innovation is a complex process characterized by highly diverse innovators, a dynamic life-cycle, and stickiness of innovation knowledge. The IMP's innovation network can be easily broken due to the fact that the network involves many different innovators across different industries and different projects. Further reasons for the fragility of the IMP's innovation network are the dynamics of the IMP life-cycle, the diversity of the IMP's innovative entities, the uniqueness of each IMP, and the temporary nature of each IMP's organizations. The innovation island formed by the breaking of an IMP's innovation network can stifle and harm innovation performance. Drawing from the knowledge-based view as well as innovation network theory, our research identifies the heterogeneous characteristics of IMP innovation. We propose a framework to analyze the formation mechanism of the IMP innovation island from three dimensions—the horizontal innovation island, the vertical innovation island, and the longitudinal innovation island. We look at the Hong Kong-ZhuhaiMacao Bridge project to elaborate the innovation island concept that negatively impacts IMP innovation. We also offer theoretical implications regarding the broader question of how IMPs can manage their innovation in practice.展开更多
Extreme meteorological disaster effects on grain production is mainly determined by the interaction between danger degree of hazard-induced factors and vulnerability degree of hazard-affected bodies. This paper treats...Extreme meteorological disaster effects on grain production is mainly determined by the interaction between danger degree of hazard-induced factors and vulnerability degree of hazard-affected bodies. This paper treats physical exposure, sensitivity of the response to the impact, and capabilities of disaster prevention and mitigation as a complex system for vulnerability degree of hazard-affected bodies, which included the external shocks and internal stability mechanism. Hazard-induced factors generate external shocks on grain production systems though exposure and sensitivity of hazard-affected body, and the result can be represented as affected area of grain. By quantile regression model, this paper depicts the quantitative relationship between hazard-induced factors of extreme meteorological disaster and the affected area in the tail of the distri- bution. Moreover, the model of production function have also been utilized to expound and prove the quantitative relationship between the affected area and final grain output under the internal stability mechanism of the agricultural natural resources endowment, the input factors of agricultural production, and the capacity of defending disaster. The empirical study of this paper finds that impact effects of drought disaster to grain production system presents the basic law of ＂diminishing marginal loss＂, namely, with the constant improvement of the grade of drought, marginal affected area produced by hazard-induced factors will be diminishing. Scenario simulation of extreme drought impact shows that by every 1% reduction in summer average rainfall, grain production of Jilin Province will fell 0.2549% and cut production of grain 14.69% eventually. In re- sponse to ensure China＇s grain security, the construction of the long-term mechanism of agricultural disaster prevention and mitigation, and the innovation of agricultural risk management tools should be also included in the agricultural policy agenda.展开更多
A case of Meropenem as a novel antibacterial agent to suppress and eliminate Agrobacterium tumefaciens in the Agrobacterium-mediated transformation of orchid protocorm-like bodies （PLBs） has been reported in this ar...A case of Meropenem as a novel antibacterial agent to suppress and eliminate Agrobacterium tumefaciens in the Agrobacterium-mediated transformation of orchid protocorm-like bodies （PLBs） has been reported in this article. The in vitro activities of meropenem and four comparator antibacterial agents against three Agrobacterium tumefaciens strains, LBA4404, EHA101, and GV3101, were assessed. In addition, the effect of meropenem on the growth of Dendrobium phalaenopsis PLBs was determined. Compared with other commonly used antibiotics （including ampicillin, carbenicillin, cefotaxime, and cefoperazone）, meropenem showed the highest activity in suppressing all tested A. tumefaciens strains （minimum inhibitory concentration [MIC] 〈 0.5 mg L^-1, which is equal to minimum bactericidal concentration [MBC]）. Meropenem, at all tested concentrations, except for 10 mg L^-1 concentration, had little negative effect on the growth of orchid tissues. The A. tumefaciens strain EHA101 in genetic transformation with vector plG121Hm in infected PLBs of the orchid was visually undetectable after a two-month subculture in 1/2 MS medium with 50 mg L^-1 meropenem and 25 mg L^-1 hygromacin. The expression and incorporation of the transgenes were confirmed by GUS histochemical assay and PCR analysis. Meropenem may be an alternative antibiotic for the effective suppression of A. tumefaciens in genetic transformation.展开更多
Flavonoids have been reported to have therapeutic potential for spinal cord injury.Hawthorn leaves have abundant content and species of total flavonoids,and studies of the effects of the total flavonoids of hawthorn l...Flavonoids have been reported to have therapeutic potential for spinal cord injury.Hawthorn leaves have abundant content and species of total flavonoids,and studies of the effects of the total flavonoids of hawthorn leaves on spinal cord injury have not been published in or outside China.Therefore,Sprague-Dawley rats were used to establish a spinal cord injury model by Allen's method.Rats were intraperitoneally injected with 0.2 m L of different concentrations of total flavonoids of hawthorn leaves(5,10,and 20 mg/kg)after spinal cord injury.Injections were administered once every 6 hours,three times a day,for 14 days.After treatment with various concentrations of total flavonoids of hawthorn leaves,the Basso,Beattie,and Bresnahan scores and histological staining indicated decreases in the lesion cavity and number of apoptotic cells of the injured spinal cord tissue;the morphological arrangement of the myelin sheath and nerve cells tended to be regular;and the Nissl bodies in neurons increased.The Basso,Beattie,and Bresnahan scores of treated spinal cord injury rats were increased.Western blot assays showed that the expression levels of pro-apoptotic Bax and cleaved caspase-3 were decreased,but the expression level of the anti-apoptotic Bcl-2 protein was increased.The improvement of the above physiological indicators showed a dose-dependent relationship with the concentration of total flavonoids of hawthorn leaves.The above findings confirm that total flavonoids of hawthorn leaves can reduce apoptosis and exert neuroprotective effects to promote the recovery of the motor function of rats with spinal cord injury.This study was approved by the Ethics Committee of the Guangxi Medical University of China(approval No.201810042)in October 2018.展开更多
Based on the data of field measurement and drilling in the Tongling area, a series of numerical simulations are carried out by using the 'Surplus Space Method' (SSM), which is first put forward in this paper a...Based on the data of field measurement and drilling in the Tongling area, a series of numerical simulations are carried out by using the 'Surplus Space Method' (SSM), which is first put forward in this paper and applied to predict the shallow-seated magmatic bodies. The results of the numerical simulations show the existence and the 3-D shape of a conical magmatic structure at a depth of-1000 m beneath the center of the area: its top offsets southwards and bifurcates to several branches, while its lower part stretches northeastwards and contracts rapidly to a point at about -1000 m depth. This point is reckoned to be a 'sink' of magma system, transferring ore materials and heat energy from the deep magma chamber to the sub-surface apophyses. The preliminary application of the SSM proves that it may be developed as a new detection means for determining the existence of shallow-seated magmatic bodies and analyzing their three-dimensional features.展开更多
Deep-water turbidite channels have attracted much attention as a focused issue in petroleum exploration and development. Extensive studies have been performed on the architecture of turbidite channels, and most resear...Deep-water turbidite channels have attracted much attention as a focused issue in petroleum exploration and development. Extensive studies have been performed on the architecture of turbidite channels, and most researches have focused on their geometric shapes, sedimentary processes and controlling factors. However, little attention has been paid to the distribution patterns, distribution laws and quantitative studies of composite sand bodies of turbidite channels. Taken one slope area of the Niger Delta Basin as an example, this study conducted a semi-quantitative to quantitative analysis on architecture of composite sand bodies of turbidite channels based on cores, well logging and seismic surveys. It is shown that turbidite channel systems can be classified as confined and unconfined channel systems. For confined channel systems, the vertical evolution process involves four stages. The sinuosity of a channel system is controlled by slope, with a negative power function relationship between them. When slope gradient reaches four degrees, the channel system is nearly straight. Based on the migration direction and migration amount of single channels within channel complexes, channel composite patterns can be divided into four classes（the lateral composite, en-echelon composite, swing composite and vertical composite） and several subclasses. Various channel composite patterns show specific distribution laws spatially. For meandering channel complexes at the middle-late evolution stage of confined channel systems, the lateral migration amongst single channels shows the features of integrity and succession. The sinuosity of single channels in the late period is greater than that in the early period, and cut-offs may occur locally when the sinuosity is larger than five degrees. This study provides a better understanding for the geological theory of deep-water sedimentary, and also improves exploitation benefits of this type of reservoirs.展开更多
文摘Alcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver disease(ALD) is a general term used to refer to this spectrum of alcohol-related liver injuries. Excessive or harmful alcohol use is ranked as one of the top five risk factors for death and disability globally and results in 2.5 million deaths and 69.4 million annual disability adjusted life years. All patients who present with clinical features of hepatitis or chronic liver disease or who have elevated serum elevated transaminase levels should be screened for an alcohol use disorder. The diagnosis of ALD can generally be made based on history, clinical and laboratory findings. However, the diagnosis of ALD can be clinically challenging as there is no single diagnostic test that confirms the diagnosis and patients may not be forthcoming about their degree of alcohol consumption. In addition, clinical findings may be absent or minimal in early ALD characterized by hepatic steatosis. Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean cor-puscular volume, gamma-glutamyltranspeptidase, and IgA to IgG ratio. In unclear cases, the diagnosis can be supported by imaging and liver biopsy. The histological features of ALD can ultimately define the diagnosis according to the typical presence and distribution of hepatic steatosis, inflammation, and Mallory-Denk bodies. Because of the potential reversible nature of ALD with sobriety, regular screening of the general population and early diagnosis are essential.
基金supports for this work provided by Na-tional basic research program of China (No. 2007CB209400)the National Natural Science Foundation of China (No. 50834004)+1 种基金the National Natural Science Foundation of China (No. 50574090) SR Foundation of China University of Mining & Technology (No. 50634050)
文摘A fully-mechanized coal mining (FMCM) technology capable of filling up the goaf with wastes (including solid wastes) is described. Industrial tests have proved that by using this technology not only can waste be re-used but also coal resources can be exploited with a higher recovery rate without removing buildings located over the working faces. Two special devices, a hydraulic support and a scraper conveyor, run side-by-side on the same working face to simultaneously realize mining and filling. These are described in detail. The tests allow analysis of rock pressure and ground subsidence when backfilling techniques are employed. These values are compared to those from mining without using backfilling techniques, under the same geological conditions. The concept of equivalent mining height is proposed based on theoretical analysis of rock pressure and ground subsidence. The upper limits of the rock pressure and ground subsidence can be estimated in backfilling mining using this concept along with traditional engineering formulae.
文摘In the present investigation, influence of gaps between multiple floating structures on wave forces is examined. Strong and complicate hydrodynamic interactions between the floating bodies are observed and the numerical computations have proved the existence of the sharp peak force response on each floating body at some special resonant wave numbers. The resonant wave number is also proved to be around kL=nπ(n=1, 2, …, ∞) with a corresponding frequency shift. A small yet finite gap width will also give influence on the resonant frequency and resonant amplitude of the wave forces, but when the distance between two aligned box-shaped floating bodies becomes big enough, the hydrodynamic interaction can be neglected. The strong hydrodynamic interaction feature has its own important practical significance for the design of module structures and the links (connection) in the whole floating body system. Moreover, the importance is closely related to the hydro-elasticity analyses of a multiple box-shaped floating body system, in which local loads may be as important as the integrated loads.
文摘The behavior of supercavitating and cavitatlng flow around a conical body of revolution with and without ventilation at several angles of attack was studied experimentally. The hydrodynamic forces for a range of cavitation number were measured. Comparisons of the appearance and the hydrodynamic forces in condition of cavity with and without ventilation were made over the same range of the cavitation number, and a well agreement was obtained. The changes of the drag were especially studied. The experimental results showed that the drag of the model decreased with the presence of supercavity under the ventilation condition.
基金the National Natural Science Foundation of China (Grant No. 50639020)the National High Technology Research and Development Program of China (863 Program, Grant No. 2006AA09Z332).
文摘A 3-D time domain method is developed to investigate the gap influence on the wave threes for 3-D multiple floating structures. Special hydrodynamic resonance due to small gaps between multiple floating structures on wave forces is examined. Strong and complicate hydrodynamic interactions between the floating bodies are observed and the numerical computations have proved the existence of the sharp peak force response on each floating body at some special resonant wave numbers. By comparison with the results from the frequency domain technique, the results obtained from the time domain method reveal the similar resonant phenomena and hydrodynamic interaction. The resonant wave numbers are also proved around kL-nπ （n = 1,2 ……∞） with a corresponding frequency shift. The strong hydrodynamic interaction feature is practically significant for the design of module structures and the links （connection） in whole the floating body system.
文摘BACKGROUND:Airway foreign bodies(AFBs)is an interdisciplinary area between emergency medicine,pediatrics and otolaryngology.It is a life-threatening condition that is not infrequently seen;however,it is poorly covered in medical literature.Accidental aspiration of an element into airways is a widespread clinical scenario among children under 3 years,predominantly males.Moreover,it is the leading cause of infantile deaths and the fourth one among preschool children.DATA RESOURCES:A systemic search was conducted in July 2015 using Pub Med/Pub Med Central Database of The National Center for Biotechnology Information(NCBI)(http://www.ncbi.nlm.nih.gov/).A total of 1 767 articles were identified and most of them were meta-analyses,systematic reviews,and case series.Those thoroughly discussing assessment and management of AFBs were retrieved.RESULTS:AFBs episodes may be either witnessed or missed.Presence of a witness for the inhalation is diagnostic.The later usually present with persistent active cough.A classical triad of paroxysmal cough,wheezing,and dyspnoea/decreased air entry was reported,though many presentations have inconsistent findings.Hence,diagnosis requires high index of clinical suspicion.Flexible fibro-optic bronchoscopy is the gold standard of diagnosis,whereas inhaled objects are best retrieved by rigid bronchoscopes.CONCLUSIONS:Close supervision of pediatrics is the hallmark of prevention.Caregivers should ensure a safe surrounding milieu,including the toys their offspring play with.Immediate complications result from direct obstruction or injury by the inhaled object.Alternatively,prolonged lodging traps air and induces inflammatory response causing atelectesis and pneumonia,respectively.
文摘Foreign body ingestion encompasses both foreign object ingestion(FOI) and esophageal food impaction(EFI) and represents a common and clinically significant scenario among patients of all ages. The immediate risk to the patient ranges from negligible to life-threatening, depending on the ingested substance,its location, patient fitness, and time to appropriate therapy. This article reviews the FOI and EFI literature and highlights important considerations and implications for pediatric and adult patients as well as their providers. Where published literature is insufficient to provide evidence-based guidance, expert opinion is included to supplement the content of this comprehensive review.
文摘In previous papers (Wencai, 2002, 2003), the author has analyzed the deep seismic reflection profiles along some of the Mesozoic plutons in East China, and has pointed out that the crustal structures around these intrusions usually correlate with a special seismic fabric called the seismic multi-arch structure. This paper will continue to show main characteristics of the seismic multi-arch structures and discuss their relationship with mantle-origin magmatism and the lithospheric thinning process. Calibration of seismic reflectors in Chinese continental drilling sites shows that small-scale arch-like reflectors can be generated by fractured eclogites or other plutons, they do not belong to the multi-arch structure specially discussed in the paper. The multi-arch structure is char-acterized by several arch-like reflectors distributed in both the upper and lower crust with granitoid plutons or stocks exposed on the surface, which do not have obvious negative Europium anomalies. Based on the distribution pattern of arch reflectors, the multi-arch magmatic structures can be divided into three main types, namely the simple vertical combination type, the spread arch magmatic struc-ture and the arch-bouquet structure. All of them correlate to mantle-origin magmatism, but occur in different places. The spread arch magmatic structures occur within a Mesozoic/Cenozoic rift zone with very thin and hot lithosphere. The vertical combination type of the multi-arch structures occurred near the rift zones where lithosphere was thin and hot. The arch-bouquet magmatic structures occur far from the rift zones where the lithosphere is not hot. The continental rifting acted as the late episode of the lithospheric thinning process seeing that the rift zones usually coincide with the thinnest parts of the lithosphere in East China. In different locations within the lithospheric thinning areas, mantle-origin magmatic activities have different characteristics, which might generate different types of crustal structures revealed by the dif
基金supported by the National Natural Science Foundation of China (Grant Nos. 10772040, 50709005 and 5092100)the Important National Science and Technology Specific Projects of China (Grant No. 2008ZX05026-02)the Open Fund of Stabe Key Laboratory of Sabllite Ocean Environment Dynamics (Grant No. SOED1002)
文摘A Time-domain Higher-Order Boundary Element Method（THOBEM） is developed for simulating wave-current interactions with 3-D floating bodies.Through a Taylor series expansion and a perturbation procedure,the model is formulated to the first-order in the wave steepness and in the current velocity,respectively.The boundary value problem is decomposed into a steady double-body flow problem and an unsteady wave problem.Higher-order boundary integral equation methods are then used to solve the proposed problems with a fourth-order Runge-Kutta method for the time marching.An artificial damping layer is adopted to dissipate the scattering waves.Different from the other time-domain numerical models,which are often focused on the wave-current interaction with restrained bodies,the present model deals with a floating hemisphere.The numerical results of wave forces,wave run-up and body response are all in a close agreement with those obtained by frequency-domain methods.The proposed numerical model is further applied to investigate wave-current interactions with a floating body of complicated geometry.In this work,the regular and focused wave combined with current interacting with a truss-spar platform is investigated.
基金supported by Prophase Project of National Key Basic Research Program of China(2012CB126312)Science and Technology Foundation of Guizhou Province of China([2012]2277)
文摘Domain of unknown function 1644 （DUF1644） is a highly conserved amino acid sequence motif present only in plants. Analysis of expression data of the family of DUF1644- containing genes indicated that they may regulate responses to abiotic stress in rice. Here we present our discovery of the role of Os.SIDP366, a member of the DUF1644 gene family, in response to drought and salinity stresses in rice. Transgenic rice plants overexpressing OsSIDP366 showed enhanced drought and salinity tolerance and reduced water loss as compared to that in the control, whereas plants with downregulated OsSIDP366 expression levels using RNA interference （RNAi） were more sensitive to salinity and drought treatments. The sensitivity to abscisic acid （ABA） treatment was not changed in OsStDP366-overexpressing plants, and OsSIDP366 expression was not affected in ABA- deficient mutants. Subcellular localization analysis revealed that OsSIDP366 is presented in the cytoplasmic foci that colocalized with protein markers for both processing bodies （PBs） and stress granules （SGs） in rice protoplasts. Digital gene expression （DGE） profile analysis indicated that stress-related genes such as SNACl, OsHAK5 and PRs were upregulated in OsSIDP366-overexpressing plants. These results suggest that OsSIDP366 may function as a regulator of the PBs/SGs and positively regulate salt and drought resistance in rice.
基金funded by the National Natural Science Foundation of China(Grant Nos.71390525 and 71620107004)the Shanghai Excellent Academic Leaders Program(Grant No.14XD1402200)
文摘Infrastructure mega-project(IMP) innovation is a complex process characterized by highly diverse innovators, a dynamic life-cycle, and stickiness of innovation knowledge. The IMP's innovation network can be easily broken due to the fact that the network involves many different innovators across different industries and different projects. Further reasons for the fragility of the IMP's innovation network are the dynamics of the IMP life-cycle, the diversity of the IMP's innovative entities, the uniqueness of each IMP, and the temporary nature of each IMP's organizations. The innovation island formed by the breaking of an IMP's innovation network can stifle and harm innovation performance. Drawing from the knowledge-based view as well as innovation network theory, our research identifies the heterogeneous characteristics of IMP innovation. We propose a framework to analyze the formation mechanism of the IMP innovation island from three dimensions—the horizontal innovation island, the vertical innovation island, and the longitudinal innovation island. We look at the Hong Kong-ZhuhaiMacao Bridge project to elaborate the innovation island concept that negatively impacts IMP innovation. We also offer theoretical implications regarding the broader question of how IMPs can manage their innovation in practice.
基金funded by the National Natural Science Foundation of China (41201551)the Project of Science and Technology Innovation in Chinese Academy of Agricultural Science (CAAS-ASTIP-201X-AII-01)the Central Public-interest Scientific Institution Basal Research Fund in Agricultural Information Institute of CAAS (2015-J-16)
文摘Extreme meteorological disaster effects on grain production is mainly determined by the interaction between danger degree of hazard-induced factors and vulnerability degree of hazard-affected bodies. This paper treats physical exposure, sensitivity of the response to the impact, and capabilities of disaster prevention and mitigation as a complex system for vulnerability degree of hazard-affected bodies, which included the external shocks and internal stability mechanism. Hazard-induced factors generate external shocks on grain production systems though exposure and sensitivity of hazard-affected body, and the result can be represented as affected area of grain. By quantile regression model, this paper depicts the quantitative relationship between hazard-induced factors of extreme meteorological disaster and the affected area in the tail of the distri- bution. Moreover, the model of production function have also been utilized to expound and prove the quantitative relationship between the affected area and final grain output under the internal stability mechanism of the agricultural natural resources endowment, the input factors of agricultural production, and the capacity of defending disaster. The empirical study of this paper finds that impact effects of drought disaster to grain production system presents the basic law of ＂diminishing marginal loss＂, namely, with the constant improvement of the grade of drought, marginal affected area produced by hazard-induced factors will be diminishing. Scenario simulation of extreme drought impact shows that by every 1% reduction in summer average rainfall, grain production of Jilin Province will fell 0.2549% and cut production of grain 14.69% eventually. In re- sponse to ensure China＇s grain security, the construction of the long-term mechanism of agricultural disaster prevention and mitigation, and the innovation of agricultural risk management tools should be also included in the agricultural policy agenda.
文摘A case of Meropenem as a novel antibacterial agent to suppress and eliminate Agrobacterium tumefaciens in the Agrobacterium-mediated transformation of orchid protocorm-like bodies （PLBs） has been reported in this article. The in vitro activities of meropenem and four comparator antibacterial agents against three Agrobacterium tumefaciens strains, LBA4404, EHA101, and GV3101, were assessed. In addition, the effect of meropenem on the growth of Dendrobium phalaenopsis PLBs was determined. Compared with other commonly used antibiotics （including ampicillin, carbenicillin, cefotaxime, and cefoperazone）, meropenem showed the highest activity in suppressing all tested A. tumefaciens strains （minimum inhibitory concentration [MIC] 〈 0.5 mg L^-1, which is equal to minimum bactericidal concentration [MBC]）. Meropenem, at all tested concentrations, except for 10 mg L^-1 concentration, had little negative effect on the growth of orchid tissues. The A. tumefaciens strain EHA101 in genetic transformation with vector plG121Hm in infected PLBs of the orchid was visually undetectable after a two-month subculture in 1/2 MS medium with 50 mg L^-1 meropenem and 25 mg L^-1 hygromacin. The expression and incorporation of the transgenes were confirmed by GUS histochemical assay and PCR analysis. Meropenem may be an alternative antibiotic for the effective suppression of A. tumefaciens in genetic transformation.
基金the National Natural Science Foundation of China,No.81860391(to GFZ)the Natural Science Foundation of Guangxi Zhuang Autonomous Region of China,No.2018GXNSFAA281144(to GFZ)the Key Research and Development Project of Guangxi Zhuang Autonomous Region of China,No.guike AB18221021(to SHZ)。
文摘Flavonoids have been reported to have therapeutic potential for spinal cord injury.Hawthorn leaves have abundant content and species of total flavonoids,and studies of the effects of the total flavonoids of hawthorn leaves on spinal cord injury have not been published in or outside China.Therefore,Sprague-Dawley rats were used to establish a spinal cord injury model by Allen's method.Rats were intraperitoneally injected with 0.2 m L of different concentrations of total flavonoids of hawthorn leaves(5,10,and 20 mg/kg)after spinal cord injury.Injections were administered once every 6 hours,three times a day,for 14 days.After treatment with various concentrations of total flavonoids of hawthorn leaves,the Basso,Beattie,and Bresnahan scores and histological staining indicated decreases in the lesion cavity and number of apoptotic cells of the injured spinal cord tissue;the morphological arrangement of the myelin sheath and nerve cells tended to be regular;and the Nissl bodies in neurons increased.The Basso,Beattie,and Bresnahan scores of treated spinal cord injury rats were increased.Western blot assays showed that the expression levels of pro-apoptotic Bax and cleaved caspase-3 were decreased,but the expression level of the anti-apoptotic Bcl-2 protein was increased.The improvement of the above physiological indicators showed a dose-dependent relationship with the concentration of total flavonoids of hawthorn leaves.The above findings confirm that total flavonoids of hawthorn leaves can reduce apoptosis and exert neuroprotective effects to promote the recovery of the motor function of rats with spinal cord injury.This study was approved by the Ethics Committee of the Guangxi Medical University of China(approval No.201810042)in October 2018.
基金This study was financially supported by the National Important Basic Research and Development Planning Program(No.1999043206)the National Natural Science Foundation of China(No.40234051)+1 种基金the Special Plan of Science and Technology of the Ministry of Land and Resources(20010103)the"Trans-century Training Program for Outstanding Talents”Fund sponsored by the.Ministry of Education.
文摘Based on the data of field measurement and drilling in the Tongling area, a series of numerical simulations are carried out by using the 'Surplus Space Method' (SSM), which is first put forward in this paper and applied to predict the shallow-seated magmatic bodies. The results of the numerical simulations show the existence and the 3-D shape of a conical magmatic structure at a depth of-1000 m beneath the center of the area: its top offsets southwards and bifurcates to several branches, while its lower part stretches northeastwards and contracts rapidly to a point at about -1000 m depth. This point is reckoned to be a 'sink' of magma system, transferring ore materials and heat energy from the deep magma chamber to the sub-surface apophyses. The preliminary application of the SSM proves that it may be developed as a new detection means for determining the existence of shallow-seated magmatic bodies and analyzing their three-dimensional features.
基金granted by the National Science and Technology Major Project of the Ministry of Science and Technology of China (Grant No.2011ZX05030-005 and No.2011ZX05009-003)the National Natural Science Foundation of China (Grant No. 40902035)
文摘Deep-water turbidite channels have attracted much attention as a focused issue in petroleum exploration and development. Extensive studies have been performed on the architecture of turbidite channels, and most researches have focused on their geometric shapes, sedimentary processes and controlling factors. However, little attention has been paid to the distribution patterns, distribution laws and quantitative studies of composite sand bodies of turbidite channels. Taken one slope area of the Niger Delta Basin as an example, this study conducted a semi-quantitative to quantitative analysis on architecture of composite sand bodies of turbidite channels based on cores, well logging and seismic surveys. It is shown that turbidite channel systems can be classified as confined and unconfined channel systems. For confined channel systems, the vertical evolution process involves four stages. The sinuosity of a channel system is controlled by slope, with a negative power function relationship between them. When slope gradient reaches four degrees, the channel system is nearly straight. Based on the migration direction and migration amount of single channels within channel complexes, channel composite patterns can be divided into four classes（the lateral composite, en-echelon composite, swing composite and vertical composite） and several subclasses. Various channel composite patterns show specific distribution laws spatially. For meandering channel complexes at the middle-late evolution stage of confined channel systems, the lateral migration amongst single channels shows the features of integrity and succession. The sinuosity of single channels in the late period is greater than that in the early period, and cut-offs may occur locally when the sinuosity is larger than five degrees. This study provides a better understanding for the geological theory of deep-water sedimentary, and also improves exploitation benefits of this type of reservoirs.
