The numerical simulation of the axial flow impeller blood pump NIVADIII is carried out by using a CFD multiphase flow model. The hydrodynamic performance of the pump and the flow field in the pump are analyzed, and th...The numerical simulation of the axial flow impeller blood pump NIVADIII is carried out by using a CFD multiphase flow model. The hydrodynamic performance of the pump and the flow field in the pump are analyzed, and the shear stress distribution is obtained. A hemolytic prediction model based on the shear stress is built based on the calculation results, and it can be used for qua- ntitative predictions of the hemolytic behavior of a blood pump. Hemolysis tests in vitro were performed 6 times with fresh bovine blood. At each time, the flow of the pump NIVADIII is 5 L/min and the outflow tract pressure is 100 mmHg. According to the tests, the plasma free hemoglobin （FHB） content and the hematocrit （HCT） are measured after 0 s, 0.5 s, 1 s, 1.5 s 4 s. At the end of each experiment Normal Index of Hemolysis （NIH） of NIVADIII is calculated. The average of NIH is 0.0055 g/100L, almost identi- cal with that obtained from the hemolytic prediction model. This method can be applied in the selection stage of a blood pump.展开更多
文摘目的探讨植入型心室辅助装置稳定性、主体血泵溶血性能及可植入性。方法首先,辅助装置在常温下连续驱动蒸馏水30 d,观察血泵转速、驱动电流等变化情况,测试其稳定性。同时,在流量5 L/min左右,出入口压差为100 mmHg情况下,心室辅助装置通过体外模拟循环实验台驱动羊血完成溶血性能测试,最后计算出血泵标准溶血指数(normal index of hematolysis,NIH)。最后,将心室辅助装置模拟主体血泵植入实验动物体内,对比术前及术后胸片,检验植入血泵对实验动物心室及周围器官的影响,验证其植入性能。结果辅助装置常温下连续驱动蒸馏水30 d,无卡泵和渗漏现象发生;血泵溶血性能良好,NIH值为(0.008±0.002)g/100 L;血泵可以很容易的植入心腔,植入血泵对实验动物心脏及周围器官无挤压变形。结论实验结果证明植入型心室辅助装置具有良好的稳定性、溶血性能以及可植入性。
基金Project supported by the National High Technology Research and Development Program of China (863 Program,Grant No. 2007AA02Z439)The Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai (Grant No. PKzxkq2010-01)the Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai (Grant No.PKR2011-01)
文摘The numerical simulation of the axial flow impeller blood pump NIVADIII is carried out by using a CFD multiphase flow model. The hydrodynamic performance of the pump and the flow field in the pump are analyzed, and the shear stress distribution is obtained. A hemolytic prediction model based on the shear stress is built based on the calculation results, and it can be used for qua- ntitative predictions of the hemolytic behavior of a blood pump. Hemolysis tests in vitro were performed 6 times with fresh bovine blood. At each time, the flow of the pump NIVADIII is 5 L/min and the outflow tract pressure is 100 mmHg. According to the tests, the plasma free hemoglobin （FHB） content and the hematocrit （HCT） are measured after 0 s, 0.5 s, 1 s, 1.5 s 4 s. At the end of each experiment Normal Index of Hemolysis （NIH） of NIVADIII is calculated. The average of NIH is 0.0055 g/100L, almost identi- cal with that obtained from the hemolytic prediction model. This method can be applied in the selection stage of a blood pump.
