Bloode-brain barrier(BBB)strictly controls matter exchange between blood and brain,and severely limits brain penetration of systemically administered drugs,resulting in ineffective drug therapy of brain diseases.Howev...Bloode-brain barrier(BBB)strictly controls matter exchange between blood and brain,and severely limits brain penetration of systemically administered drugs,resulting in ineffective drug therapy of brain diseases.However,during the onset and progression of brain diseases,BBB alterations evolve inevitably.In this review,we focus on nanoscale brain-targeting drug delivery strategies designed based on BBB evolutions and related applications in various brain diseases including Alzheimer’s disease,Parkinson’s disease,epilepsy,stroke,traumatic brain injury and brain tumor.The advances on optimization of small molecules for BBB crossing and non-systemic administration routes(e.g.,intranasal treatment)for BBB bypassing are not included in this review.展开更多
The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could...The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an in-creased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deifcits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells.展开更多
目的通过基于精准护理理念干预方案的实施,探讨其对妊娠糖尿病(GDM)患者血糖控制、分娩方式及围生儿结局的影响。方法选取2019年6月至2020年10月在新乡医学院第一附属医院就诊的120例GDM患者,采用随机数表法将患者分为对照组和研究组,每...目的通过基于精准护理理念干预方案的实施,探讨其对妊娠糖尿病(GDM)患者血糖控制、分娩方式及围生儿结局的影响。方法选取2019年6月至2020年10月在新乡医学院第一附属医院就诊的120例GDM患者,采用随机数表法将患者分为对照组和研究组,每组60例。对照组接受常规护理及健康宣教;研究组接受精准化护理策略。比较两组患者实施不同护理方式后血糖水平,统计两组患者分娩方式及围生儿结局。结果护理前两组患者血糖水平比较,差异无统计学意义(P>0.05)。护理后,两组患者空腹血糖(FPG)、餐后2小时血糖(2 h PG)水平均低于护理前,差异有统计学意义(P<0.05);研究组FPG、2 h PG水平低于对照组(P<0.05);研究组分娩方式、围生儿结局均优于对照组,差异有统计学意义(P<0.05)。结论通过对GDM患者实施基于精准护理理念的干预方案,可有效控制其血糖水平,降低剖宫产率、巨大儿发生率及新生儿低血糖发生率,改善妊娠结局,促进母婴健康。展开更多
基金funded by the international cooperative project of the National Key R&D Program of China(No.2017YFE0126900)the National Natural Science Foundation of China(No.81703428 and No.81973254)+2 种基金the Natural Science Foundation of Jiangsu Province(No.BK20191421,China)the Suzhou Science and Technology Development Project(No.SYS2019033,China)the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD,China)
文摘Bloode-brain barrier(BBB)strictly controls matter exchange between blood and brain,and severely limits brain penetration of systemically administered drugs,resulting in ineffective drug therapy of brain diseases.However,during the onset and progression of brain diseases,BBB alterations evolve inevitably.In this review,we focus on nanoscale brain-targeting drug delivery strategies designed based on BBB evolutions and related applications in various brain diseases including Alzheimer’s disease,Parkinson’s disease,epilepsy,stroke,traumatic brain injury and brain tumor.The advances on optimization of small molecules for BBB crossing and non-systemic administration routes(e.g.,intranasal treatment)for BBB bypassing are not included in this review.
基金supported by Proj.PRIN prot.2007AF3XH4_005,"Fondazione Cassa di Risparmio di Roma",and"Ministero della Salute"Grant No.RF-FGB-2005-150198
文摘The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an in-creased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deifcits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells.
文摘目的通过基于精准护理理念干预方案的实施,探讨其对妊娠糖尿病(GDM)患者血糖控制、分娩方式及围生儿结局的影响。方法选取2019年6月至2020年10月在新乡医学院第一附属医院就诊的120例GDM患者,采用随机数表法将患者分为对照组和研究组,每组60例。对照组接受常规护理及健康宣教;研究组接受精准化护理策略。比较两组患者实施不同护理方式后血糖水平,统计两组患者分娩方式及围生儿结局。结果护理前两组患者血糖水平比较,差异无统计学意义(P>0.05)。护理后,两组患者空腹血糖(FPG)、餐后2小时血糖(2 h PG)水平均低于护理前,差异有统计学意义(P<0.05);研究组FPG、2 h PG水平低于对照组(P<0.05);研究组分娩方式、围生儿结局均优于对照组,差异有统计学意义(P<0.05)。结论通过对GDM患者实施基于精准护理理念的干预方案,可有效控制其血糖水平,降低剖宫产率、巨大儿发生率及新生儿低血糖发生率,改善妊娠结局,促进母婴健康。
